全文获取类型
收费全文 | 3385749篇 |
免费 | 251665篇 |
国内免费 | 5016篇 |
专业分类
耳鼻咽喉 | 47171篇 |
儿科学 | 111099篇 |
妇产科学 | 93832篇 |
基础医学 | 491753篇 |
口腔科学 | 96806篇 |
临床医学 | 305968篇 |
内科学 | 649214篇 |
皮肤病学 | 74112篇 |
神经病学 | 270205篇 |
特种医学 | 129205篇 |
外国民族医学 | 902篇 |
外科学 | 508932篇 |
综合类 | 76490篇 |
现状与发展 | 13篇 |
一般理论 | 1299篇 |
预防医学 | 267279篇 |
眼科学 | 79316篇 |
药学 | 253627篇 |
14篇 | |
中国医学 | 6361篇 |
肿瘤学 | 178832篇 |
出版年
2018年 | 35777篇 |
2017年 | 27251篇 |
2016年 | 30539篇 |
2015年 | 34724篇 |
2014年 | 48787篇 |
2013年 | 73912篇 |
2012年 | 101089篇 |
2011年 | 107350篇 |
2010年 | 63777篇 |
2009年 | 60495篇 |
2008年 | 101346篇 |
2007年 | 107753篇 |
2006年 | 108952篇 |
2005年 | 106010篇 |
2004年 | 102537篇 |
2003年 | 98207篇 |
2002年 | 95841篇 |
2001年 | 151208篇 |
2000年 | 155957篇 |
1999年 | 131878篇 |
1998年 | 38346篇 |
1997年 | 33986篇 |
1996年 | 33965篇 |
1995年 | 32496篇 |
1994年 | 30205篇 |
1993年 | 28514篇 |
1992年 | 105526篇 |
1991年 | 103173篇 |
1990年 | 100780篇 |
1989年 | 97395篇 |
1988年 | 90172篇 |
1987年 | 88530篇 |
1986年 | 83710篇 |
1985年 | 80628篇 |
1984年 | 60450篇 |
1983年 | 51847篇 |
1982年 | 30773篇 |
1981年 | 27747篇 |
1979年 | 56805篇 |
1978年 | 40223篇 |
1977年 | 33744篇 |
1976年 | 32147篇 |
1975年 | 34381篇 |
1974年 | 41601篇 |
1973年 | 39786篇 |
1972年 | 37135篇 |
1971年 | 35072篇 |
1970年 | 32345篇 |
1969年 | 30732篇 |
1968年 | 28098篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
Qian Zhang Larry D. Mesner Gina M. Calabrese Naomi Dirckx Zhu Li Angela Verardo Qian Yang Robert J. Tower Marie-Claude Faugere Charles R. Farber Thomas L. Clemens 《The Journal of clinical investigation》2021,131(7)
Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. GWAS have identified hundreds of loci influencing BMD, but few have been functionally analyzed. In this study, we show that SNPs within a BMD locus on chromosome 14q32.32 alter splicing and expression of PAR-1a/microtubule affinity regulating kinase 3 (MARK3), a conserved serine/threonine kinase known to regulate bioenergetics, cell division, and polarity. Mice lacking Mark3 either globally or selectively in osteoblasts have increased bone mass at maturity. RNA profiling from Mark3-deficient osteoblasts suggested changes in the expression of components of the Notch signaling pathway. Mark3-deficient osteoblasts exhibited greater matrix mineralization compared with controls that was accompanied by reduced Jag1/Hes1 expression and diminished downstream JNK signaling. Overexpression of Jag1 in Mark3-deficient osteoblasts both in vitro and in vivo normalized mineralization capacity and bone mass, respectively. Together, these findings reveal a mechanism whereby genetically regulated alterations in Mark3 expression perturb cell signaling in osteoblasts to influence bone mass. 相似文献
3.
4.
5.
6.
Abd-Allah H. El Ashmawy Kathleen Dowson Ahmed El-Bakoury Hazem A.H. Hosny Rathan Yarlagadda Jonathan Keenan 《The Journal of arthroplasty》2021,36(3):816-822.e1
BackgroundTotal hip and knee arthroplasties are increasingly performed operations, and routine follow-up places huge demands on orthopedic services. This study investigates the effectiveness, patients’ satisfaction, and cost reduction of Virtual Joint Replacement Clinic (VJRC) follow-up of total hip arthroplasty and total knee arthroplasty patients in a university hospital. VJRC is especially valuable when in-person appointments are not advised or feasible such as during the COVID-19 pandemic.MethodsA total of 1749 patients who were invited for VJRC follow-up for knee or hip arthroplasty from January 2017 to December 2018 were included in this retrospective study. Patients were referred to VJRC after their 6-week postoperative review. Routine VJRC postoperative review was undertaken at 1 and 7 years and then 3-yearly thereafter. We evaluated the VJRC patient response rate, acceptability, and outcome. Patient satisfaction was measured in a subgroup of patients using a satisfaction survey. VJRC costs were calculated compared to face-to-face follow-up.ResultsThe VJRC had a 92.05% overall response rate. Only 7.22% required further in-person appointments with only 3% being reviewed by an orthopedic consultant. VJRC resulted in an estimated saving of £42,644 per year at our institution. The patients’ satisfaction survey showed that 89.29% of the patients were either satisfied or very satisfied with VJRC follow-up.ConclusionVJRC follow-up for hip and knee arthroplasty patients is an effective alternative to in-person clinic assessment which is accepted by patients, has high patient satisfaction, and can reduce the cost to both health services and patients. 相似文献
7.
8.
9.
10.