全文获取类型
收费全文 | 3389篇 |
免费 | 176篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 155篇 |
妇产科学 | 48篇 |
基础医学 | 442篇 |
口腔科学 | 35篇 |
临床医学 | 201篇 |
内科学 | 515篇 |
皮肤病学 | 48篇 |
神经病学 | 239篇 |
特种医学 | 94篇 |
外科学 | 419篇 |
综合类 | 87篇 |
预防医学 | 204篇 |
眼科学 | 174篇 |
药学 | 453篇 |
中国医学 | 45篇 |
肿瘤学 | 377篇 |
出版年
2023年 | 28篇 |
2022年 | 60篇 |
2021年 | 114篇 |
2020年 | 60篇 |
2019年 | 72篇 |
2018年 | 92篇 |
2017年 | 62篇 |
2016年 | 96篇 |
2015年 | 89篇 |
2014年 | 107篇 |
2013年 | 149篇 |
2012年 | 238篇 |
2011年 | 239篇 |
2010年 | 151篇 |
2009年 | 129篇 |
2008年 | 187篇 |
2007年 | 171篇 |
2006年 | 157篇 |
2005年 | 155篇 |
2004年 | 139篇 |
2003年 | 111篇 |
2002年 | 87篇 |
2001年 | 50篇 |
2000年 | 66篇 |
1999年 | 52篇 |
1998年 | 30篇 |
1997年 | 19篇 |
1996年 | 23篇 |
1995年 | 21篇 |
1994年 | 20篇 |
1993年 | 18篇 |
1992年 | 45篇 |
1991年 | 41篇 |
1990年 | 33篇 |
1989年 | 55篇 |
1988年 | 44篇 |
1987年 | 37篇 |
1986年 | 32篇 |
1985年 | 31篇 |
1984年 | 28篇 |
1983年 | 27篇 |
1982年 | 15篇 |
1981年 | 16篇 |
1979年 | 34篇 |
1978年 | 15篇 |
1976年 | 14篇 |
1974年 | 10篇 |
1973年 | 15篇 |
1972年 | 14篇 |
1970年 | 10篇 |
排序方式: 共有3576条查询结果,搜索用时 0 毫秒
1.
The abdominal compartment syndrome is a life threatening condition resulting from pathologic elevation of the intraabdominal pressure. Prompt diagnosis is required to avoid significant sequelae. Diagnosis of this syndrome is based on clinical findings and intra abdominal pressure monitoring. Treatment consists of decompressive laparotomy, which corrects the pathology. Various surgical techniques are described to manage the open abdomen. Despite considerable attention accorded to this disorder, it is still associated with high morbidity and mortality. This review article deals with the identification of risk factors, pathophysiology, diagnostic criteria and treatment of critically ill patients with the abdominal compartment syndrome. 相似文献
2.
Girja S. Shukla S. V. Chandra 《Archives of environmental contamination and toxicology》1987,16(3):303-310
Growing rats were exposed to 5 mg/L Pb,ad libitum in drinking water, and administered low or high doses of Mn and Cd intraperitoneal (i.p.) for 30 days. Some groups of animals were also administered combinations of Pb + Mn and Pb + Cd in an identical manner. Analysis of Pb, Mn, and Cd in tissue samples showed the expected dose-dependent accumulation when the metal was administered singly. However, combined treatment produced different types of metal shift in different tissues. Enhanced accumulation of all three metals in the brain, Mn in liver, Pb in kidney and Cd in testis and kidney after combined exposure may make target organs vulnerable to the toxic effects of metals, even when encountered at low concentrations. Further, the decreased levels of blood Pb after combined treatment with Cd or Mn suggests that the significance of blood Pb level as a diagnostic aid for Pb toxicity in coexposed conditions may not be of much value. Changes in the metallic distribution within the tissues after coexposure may be the result of a competition between the administered metals for common binding sites. 相似文献
3.
A sublethal concentration of technical grade endosulfan (END) inhibited 35 to 55% of the activities of cytoplasmic malate dehydrogenase (cMDH), mitochondrial malate dehydrogenase (mMDH), and lactate dehydrogenase (LDH) in the liver and the skeletal muscle of a freshwater catfish, Clarias batrachus, after 7 days of exposure. The activity remained in the inhibited state up to 28 days. The withdrawal of END from the medium after 1 week of exposure gradually restored the activities to control levels within 21 days in the skeletal muscle and 28 days in the liver. The administration of actinomycin D or cycloheximide between the 14th and the 21st day of the withdrawal of END almost completely inhibited the withdrawal-dependent recovery in the activities of all the three enzymes. This indicates de novo synthesis of the enzymes during the recovery period. A conjoint treatment of END and triiodothyronine (T3) raised the activities of cMDH, mMDH, and LDH in the liver and the skeletal muscle up to the control levels. This shows that the inhibitory effect of END may be relieved in presence of T3. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed few changes in the pattern of cytoplasmic proteins of the liver and the skeletal muscle in response to exposure to END. 相似文献
4.
Asymptomatic infection with Loa loa, an eye worm, is reported in a 32-year old Zambian woman. The patient revealed up to 28% eosinophilia but microfileraemia was not noticed. One gravid female parasite 56 X 0.56 mm, extracted from lower lid of left eye of the patient, is described. Treatment with diethylcarbamazine (DEC) extended over three weeks was successful against another parasite in tissues. 相似文献
5.
6.
Platelet activating factor (PAF) stimulated aggregation and [32P]-phosphatidic acid (PA) production was compared in normal and diabetic human subjects in platelet rich plasma. The concentration of PAF for half maximal (50%) aggregation of normal and diabetic platelets was 50 nM and 8 nM, respectively. PAF stimulated [32P]-PA production (a metabolite of phospholipase C pathway) was also greater in the platelets from diabetic subjects. This [32P]-PA production was inhibited by the PAF receptor antagonists SRI-63441 and SRI-63675. When the levels of glycosylated hemoglobin (HbA1c) were compared with the PAF stimulated [32P]-PA production a significant relationship was observed. These studies have demonstrated for the first time that diabetic human platelets show hypersensitivity to PAF in both aggregation and [32P]-PA production compared to normal subjects. This may be a result of some modification in phospholipid turnover mechanism and is receptor mediated. Further, the relationship of the degree of aggregation and [32P]-PA production to the level of HbA1c suggest that the insulin deficiency may contribute to these effects. 相似文献
7.
S ArunabhDutta Gupta S Bal A K Sarda M Vijayraghavan N K Shukla M M Kapur 《The Japanese journal of surgery》1988,18(4):455-459
A case of extramedullary plasmacytoma in the soft tissues of the posterior chest wall of an 80-year old man is reported herein. Immunofluorescence study showed that the tumor cells produced IgG lambda. An M-component was also detected in the patient's serum by paper electrophoresis. Two months following the open biopsy done to establish diagnosis, the tumor underwent spontaneous regression and the M-component in the serum also disappeared. This is the first case report of spontaneous regression of an extramedullary plasmacytoma and the probable reasons for this spontaneous regression are discussed herein. 相似文献
8.
9.
Lack of interaction between nefazodone and cimetidine: a steady state pharmacokinetic study in humans. 下载免费PDF全文
The steady-state pharmacokinetic interaction between nefazodone and cimetidine was evaluated in a three-period crossover study consisting of three treatments of 1 week duration with a 1 week washout between treatments. The 18 healthy, male study subjects received: nefazodone hydrochloride 200 mg twice daily (every 12 h) for 6 days; cimetidine 300 mg four times daily for 6 days; and 200 mg nefazodone hydrochloride twice daily + 300 mg cimetidine four times daily for 6 days. On day 7 of each treatment, only the morning dose was administered. Serial blood samples were collected for pharmacokinetic analysis after drug administration on day 7 of each treatment; blood samples for trough levels (Cmin) to assess attainment of steady state, were also collected just prior to the morning doses on days 2-7 of each study period. Plasma samples were assayed for cimetidine, and nefazodone and its metabolites hydroxynefazodone and m-chlorophenylpiperazine by specific, validated h.p.l.c. methods. Statistical analyses of Cmin data indicated that, regardless of treatment, steady state was achieved for cimetidine by day 2 and for nefazodone and its metabolites by day 3 of multiple dosing, and that there were no significant differences in Cmin levels between treatments. When nefazodone and cimetidine were co-administered for 1 week, no change in steady-state pharmacokinetic parameters for cimetidine, nefazodone or hydroxynefazodone was observed compared with each drug dosed alone.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
10.
Protection against 7,12-dimethylbenzanthracene-induced tumour initiation by protein A in mouse skin.
S Kumar Y Shukla A K Prasad A S Verma P D Dwivedi N K Mehrotra P K Ray 《Cancer letters》1992,61(2):105-110
Protein A is an immunostimulating glycoprotein obtained from Staphylococcus aureus Cowan I. Its antitumour activity is proven in various tumour models. Its ability to provide protection against tumour initiation by the chemical carcinogen 7,12-dimethylbenzanthracene (DMBA) has been investigated in the present study using a mouse skin model of two-stage carcinogenesis. Protein A was administered intraperitoneally (1 microgram/animal 20 g body wt.) twice a week for 2 weeks, prior to initiation by DMBA. The promotion was performed by twice weekly applications of 12-O-tetradecanoyl phorbol-13-acetate (TPA) (3 or 5 micrograms/animal in 100 microliters acetone). Protein A provided significant protection to animals from DMBA-induced tumour initiation as was observed by the decrease in cumulative number of tumours, percent of animals developing tumours, number of tumours per animal and rate of tumour growth. Our data indicate that protein A has anticarcinogenic properties. 相似文献