全文获取类型
收费全文 | 33372篇 |
免费 | 7513篇 |
国内免费 | 140篇 |
专业分类
耳鼻咽喉 | 476篇 |
儿科学 | 704篇 |
妇产科学 | 629篇 |
基础医学 | 2609篇 |
口腔科学 | 1834篇 |
临床医学 | 7810篇 |
内科学 | 7242篇 |
皮肤病学 | 793篇 |
神经病学 | 4009篇 |
特种医学 | 1558篇 |
外科学 | 4899篇 |
综合类 | 221篇 |
现状与发展 | 2篇 |
一般理论 | 16篇 |
预防医学 | 3563篇 |
眼科学 | 815篇 |
药学 | 1200篇 |
中国医学 | 18篇 |
肿瘤学 | 2627篇 |
出版年
2024年 | 153篇 |
2023年 | 1389篇 |
2022年 | 534篇 |
2021年 | 1132篇 |
2020年 | 1405篇 |
2019年 | 844篇 |
2018年 | 1897篇 |
2017年 | 1949篇 |
2016年 | 1980篇 |
2015年 | 2115篇 |
2014年 | 2518篇 |
2013年 | 2599篇 |
2012年 | 1924篇 |
2011年 | 1965篇 |
2010年 | 1825篇 |
2009年 | 2160篇 |
2008年 | 1610篇 |
2007年 | 1494篇 |
2006年 | 1445篇 |
2005年 | 1187篇 |
2004年 | 1076篇 |
2003年 | 951篇 |
2002年 | 774篇 |
2001年 | 559篇 |
2000年 | 404篇 |
1999年 | 457篇 |
1998年 | 424篇 |
1997年 | 403篇 |
1996年 | 373篇 |
1995年 | 319篇 |
1994年 | 218篇 |
1993年 | 207篇 |
1992年 | 225篇 |
1991年 | 211篇 |
1990年 | 185篇 |
1989年 | 185篇 |
1988年 | 170篇 |
1987年 | 145篇 |
1986年 | 114篇 |
1985年 | 129篇 |
1984年 | 128篇 |
1983年 | 85篇 |
1982年 | 87篇 |
1981年 | 68篇 |
1980年 | 65篇 |
1979年 | 98篇 |
1978年 | 74篇 |
1977年 | 71篇 |
1976年 | 57篇 |
1973年 | 54篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Louise Danielsson RPT MSc Susanne Rosberg RPT PhD 《Scandinavian journal of caring sciences》2015,29(3):501-509
Although depression is associated to physical discomfort, meanings of the body in depression are rarely addressed in clinical research. Drawing on the concept of the lived body, this study explores depression as an embodied phenomenon. Using a hermeneutic phenomenological approach, the analysis of narrative‐based interviews with 11 depressed adults discloses a thematic structure of an embodied process of an ambiguous striving against fading. Five subthemes elicit different dimensions of this process, interpreted as disabling or enabling: feeling estranged, feeling confined, feeling burdensome, sensing life and seeking belongingness. In relation to clinical practice, we suggest that the interdisciplinary team can focus on enhancing the enabling dimensions, for example through guided physical activities to support the patient to feel more alive, capable and connected. Moreover, we suggest that the treatment process benefits from an increased awareness of the ambiguity in the patient's struggle, acknowledging both destructive and recharging elements of the withdrawing, and the perceived conflict in‐between. 相似文献
3.
Well‐being,health and fitness of children who use wheelchairs: Feasibility study protocol to develop child‐centred ‘keep‐fit’ exercise interventions
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
4.
Interprofessional collaboration and communication in nursing homes: a qualitative exploration of problems in medical care for nursing home residents – study protocol
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
5.
Cost‐Effectiveness and Cost‐Utility Analysis of Spinal Cord Stimulation in Patients With Failed Back Surgery Syndrome: Results From the PRECISE Study
下载免费PDF全文
![点击此处可从《Neuromodulation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Furio Zucco MD Roberta Ciampichini MSc Angelo Lavano MD Amedeo Costantini MD Marisa De Rose MD Paolo Poli MD Gianpaolo Fortini MD Laura Demartini MD Enrico De Simone MD Valentino Menardo MD Piero Cisotto MD Mario Meglio MD Luciana Scalone PhD Lorenzo G. Mantovani DSc 《Neuromodulation》2015,18(4):266-276
6.
7.
Weiyu Ye Anna Olsson-Brown Robert A. Watson Vincent T. F. Cheung Robert D. Morgan Isar Nassiri Rosalin Cooper Chelsea A. Taylor Umair Akbani Oliver Brain Rubeta N. Matin Nicholas Coupe Mark R. Middleton Mark Coles Joseph J. Sacco Miranda J. Payne Benjamin P. Fairfax 《British journal of cancer》2021,124(10):1661
Background Immune checkpoint blockers (ICBs) activate CD8+ T cells, eliciting both anti-cancer activity and immune-related adverse events (irAEs). The relationship of irAEs with baseline parameters and clinical outcome is unclear.Methods Retrospective evaluation of irAEs on survival was performed across primary (N = 144) and secondary (N = 211) independent cohorts of patients with metastatic melanoma receiving single agent (pembrolizumab/nivolumab—sICB) or combination (nivolumab and ipilimumab—cICB) checkpoint blockade. RNA from pre-treatment and post-treatment CD8+ T cells was sequenced and differential gene expression according to irAE development assessed.Results 58.3% of patients developed early irAEs and this was associated with longer progression-free (PFS) and overall survival (OS) across both cohorts (log-rank test, OS: P < 0.0001). Median survival for patients without irAEs was 16.6 months (95% CI: 10.9–33.4) versus not-reached (P = 2.8 × 10−6). Pre-treatment monocyte and neutrophil counts, but not BMI, were additional predictors of clinical outcome. Differential expression of numerous gene pathway members was observed in CD8+ T cells according to irAE development, and patients not developing irAEs demonstrating upregulated CXCR1 pre- and post-treatment.Conclusions Early irAE development post-ICB is associated with favourable survival in MM. Development of irAEs is coupled to expression of numerous gene pathways, suggesting irAE development in-part reflects baseline immune activation.Subject terms: Immunotherapy, Melanoma 相似文献
8.
9.
10.
A typical time series in functional magnetic resonance imaging (fMRI) exhibits autocorrelation, that is, the samples of the time series are dependent. In addition, temporal filtering, one of the crucial steps in preprocessing of functional magnetic resonance images, induces its own autocorrelation. While performing connectivity analysis in fMRI, the impact of the autocorrelation is largely ignored. Recently, autocorrelation has been addressed by variance correction approaches, which are sensitive to the sampling rate. In this article, we aim to investigate the impact of the sampling rate on the variance correction approaches. Toward this end, we first derived a generalized expression for the variance of the sample Pearson correlation coefficient (SPCC) in terms of the sampling rate and the filter cutoff frequency, in addition to the autocorrelation and cross‐covariance functions of the time series. Through simulations, we illustrated the importance of the variance correction for a fixed sampling rate. Using the real resting state fMRI data sets, we demonstrated that the data sets with higher sampling rates were more prone to false positives, in agreement with the existing empirical reports. We further demonstrated with single subject results that for the data sets with higher sampling rates, the variance correction strategy restored the integrity of true connectivity. 相似文献