收费全文 | 24000篇 |
免费 | 1397篇 |
国内免费 | 186篇 |
耳鼻咽喉 | 326篇 |
儿科学 | 672篇 |
妇产科学 | 808篇 |
基础医学 | 2563篇 |
口腔科学 | 672篇 |
临床医学 | 1977篇 |
内科学 | 4852篇 |
皮肤病学 | 517篇 |
神经病学 | 1149篇 |
特种医学 | 1024篇 |
外国民族医学 | 11篇 |
外科学 | 4178篇 |
综合类 | 489篇 |
现状与发展 | 2篇 |
一般理论 | 15篇 |
预防医学 | 1949篇 |
眼科学 | 740篇 |
药学 | 2097篇 |
中国医学 | 153篇 |
肿瘤学 | 1389篇 |
2023年 | 255篇 |
2022年 | 710篇 |
2021年 | 1301篇 |
2020年 | 704篇 |
2019年 | 888篇 |
2018年 | 1178篇 |
2017年 | 719篇 |
2016年 | 781篇 |
2015年 | 806篇 |
2014年 | 1111篇 |
2013年 | 1340篇 |
2012年 | 1871篇 |
2011年 | 2024篇 |
2010年 | 1146篇 |
2009年 | 872篇 |
2008年 | 1269篇 |
2007年 | 1282篇 |
2006年 | 1196篇 |
2005年 | 1173篇 |
2004年 | 989篇 |
2003年 | 930篇 |
2002年 | 807篇 |
2001年 | 214篇 |
2000年 | 187篇 |
1999年 | 168篇 |
1998年 | 112篇 |
1997年 | 104篇 |
1996年 | 97篇 |
1995年 | 80篇 |
1994年 | 72篇 |
1993年 | 68篇 |
1992年 | 75篇 |
1991年 | 79篇 |
1990年 | 80篇 |
1989年 | 63篇 |
1988年 | 72篇 |
1987年 | 66篇 |
1986年 | 66篇 |
1985年 | 54篇 |
1984年 | 56篇 |
1983年 | 52篇 |
1982年 | 39篇 |
1981年 | 31篇 |
1980年 | 30篇 |
1979年 | 23篇 |
1978年 | 33篇 |
1975年 | 24篇 |
1974年 | 33篇 |
1973年 | 39篇 |
1972年 | 25篇 |
Background
Refractory acute myeloid leukemia (AML) includes AML includes failure of disease to respond to standard induction chemotherapy, relapse within 6 months after first CR, and 2 or more relapses. The outcome of these patients is usually very poor; only a small proportion can be rescued by allogenic hematopoietic stem-cell transplantation (allo-HSCT). The aim of this study was to evaluate the efficacy and feasibility of allo-HSCT in patients with refractory AML.Patients and Methods
We retrospectively analyzed the clinical outcome of 91 patients who were diagnosed with treatment-refractory AML at Hacettepe University Hospital between January 2002 and June 2018. Patients' disease status included refractory AML, defined as failure to respond to standard induction chemotherapy and relapse within 6 months after first complete remission.Results
The median follow-up was 12 months (range, 0.5-184 months) for the entire group. Kaplan-Meier estimates of the 3-year overall survival for patients who underwent allo-HSCT and patients who received only salvage chemotherapy were 67% and 12%, respectively. Additionally, the Kaplan-Meier estimates of 5-year overall survival for patients who underwent allo-HSCT and patients who received only salvage chemotherapy were 44% and 4%, respectively (P < .001). Complete remission was obtained in 25 patients (83.3%) who underwent allo-HSCT; however, the disease of only 3 patients (3.8%) exhibited complete response after salvage chemotherapy.Conclusion
Allo-HSCT is still the best-known treatment option with curative potential in patients with treatment-refractory AML. Therefore, all efforts should be made in an attempt to find a suitable matched donor in order to perform allo-HSCT. 相似文献Background
The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes zoster in adults. Here we present a comprehensive overview of the safety data from these studies.Methods
Adults aged ≥50 (ZOE-50) and ≥70 (ZOE-70) years were randomly vaccinated with RZV or placebo. Safety analyses were performed on the pooled total vaccinated cohort, consisting of participants receiving at least one dose of RZV or placebo. Solicited and unsolicited adverse events (AEs) were collected for 7 and 30?days after each vaccination, respectively. Serious AEs (SAEs) were collected from the first vaccination until 12?months post-last dose. Fatal AEs, vaccination-related SAEs, and potential immune-mediated diseases (pIMDs) were collected during the entire study period.Results
Safety was evaluated in 14,645 RZV and 14,660 placebo recipients. More RZV than placebo recipients reported unsolicited AEs (50.5% versus 32.0%); the difference was driven by transient injection site and solicited systemic reactions that were generally seen in the first week post-vaccination. The occurrence of overall SAEs (RZV: 10.1%; Placebo: 10.4%), fatal AEs (RZV: 4.3%; Placebo: 4.6%), and pIMDs (RZV: 1.2%; Placebo: 1.4%) was balanced between groups. The occurrence of possible exacerbations of pIMDs was rare and similar between groups. Overall, except for the expected local and systemic symptoms, the safety results were comparable between the RZV and Placebo groups irrespective of participant age, gender, or race.Conclusions
No safety concerns arose, supporting the favorable benefit-risk profile of RZV. 相似文献Butyrylcholinesterase (BChE) is a serine esterase that plays a role in the detoxification of natural as well as synthetic ester-bond-containing compounds. Alterations in BChE activity are associated with a number of diseases. Cholinergic system abnormalities in particular are correlated with the formation of senile plaques in Alzheimer’s disease (AD), and administration of cholinesterase inhibitors is a common therapeutic approach used to treat AD.
Here, our aim was to study the interaction between BChE and fluoxetine.
Molecular docking simulations revealed that fluoxetine penetrated deep into the active-site gorge of BChE and that it was engaged in stabilizing noncovalent interactions with multiple subsites. In substrate kinetic studies, the Vm, Km, kcat and kcat/Km values were found to be 20.59?±?0.36?U mg?1 protein, 194?±?14?µM, 1.3?×?108?s?1 and 6.7?×?105?µM?1s?1, respectively. Based on inhibitory studies, fluoxetine appeared to inhibit BChE competitively, with an IC50 value of 104?µM and a Ki value of 36.3?±?4.7?µM.
Overall, both the low Ki value and the high number of BChE–fluoxetine interactions suggest that fluoxetine is a potent inhibitor of BChE, although in vivo mechanisms for the direct effects of BChE inhibition on various pathologies remain to be further investigated.
Areas covered: The authors discuss basic information about CTCL and mogamulizumab’s mechanism of action. Then, the authors discuss the agent’s efficacy. Finally, the authors evaluate the safety of mogamulizumab in comparison to other agents available in CTCL.
Expert opinion: Mogamulizumab has been shown to be an effective and well tolerated therapy for patients with relapsed and refractory MF/SS with excellent activity in the circulating component of the disease. 相似文献