全文获取类型
收费全文 | 3288篇 |
免费 | 213篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 77篇 |
妇产科学 | 58篇 |
基础医学 | 636篇 |
口腔科学 | 75篇 |
临床医学 | 305篇 |
内科学 | 603篇 |
皮肤病学 | 68篇 |
神经病学 | 251篇 |
特种医学 | 165篇 |
外科学 | 385篇 |
综合类 | 25篇 |
预防医学 | 234篇 |
眼科学 | 56篇 |
药学 | 405篇 |
中国医学 | 22篇 |
肿瘤学 | 126篇 |
出版年
2023年 | 20篇 |
2022年 | 62篇 |
2021年 | 90篇 |
2020年 | 61篇 |
2019年 | 78篇 |
2018年 | 126篇 |
2017年 | 84篇 |
2016年 | 151篇 |
2015年 | 132篇 |
2014年 | 164篇 |
2013年 | 281篇 |
2012年 | 218篇 |
2011年 | 221篇 |
2010年 | 197篇 |
2009年 | 119篇 |
2008年 | 140篇 |
2007年 | 142篇 |
2006年 | 139篇 |
2005年 | 116篇 |
2004年 | 105篇 |
2003年 | 91篇 |
2002年 | 79篇 |
2001年 | 37篇 |
2000年 | 38篇 |
1999年 | 34篇 |
1998年 | 44篇 |
1997年 | 26篇 |
1996年 | 30篇 |
1995年 | 23篇 |
1994年 | 21篇 |
1993年 | 23篇 |
1992年 | 22篇 |
1991年 | 15篇 |
1990年 | 17篇 |
1989年 | 18篇 |
1988年 | 13篇 |
1986年 | 15篇 |
1984年 | 13篇 |
1982年 | 14篇 |
1981年 | 15篇 |
1980年 | 15篇 |
1979年 | 17篇 |
1977年 | 14篇 |
1976年 | 15篇 |
1975年 | 13篇 |
1974年 | 12篇 |
1973年 | 12篇 |
1967年 | 13篇 |
1965年 | 11篇 |
1963年 | 11篇 |
排序方式: 共有3530条查询结果,搜索用时 15 毫秒
1.
ABSTRACTAlthough communication about sexuality is a significant pathway through which peers influence adolescent sexual development, little research has examined the role of peer networks in the use of sexualized media. We applied a social network approach to assess the role of close peers in adolescent pornography use and sexting in a sample of Croatian high school students. Sexual conversation networks’ characteristics did not correlate with pornography use. In contrast, sexting was associated with the proportion of same gender peers, the proportion of older peers and the proportion of sexually experienced peers in the network – pointing to the role of peer influence. Participants’ gender did not moderate these associations. Specific mechanisms underlying the observed associations and the role of peer selection remain important tasks for future research. 相似文献
2.
3.
4.
5.
6.
7.
The temporal bones from fetuses with known autosomal trisomy syndromes were examined histopathologically after spontaneous or induced abortions. Fetal ages dated from the 17th to the 24th week of pregnancy. In all, 17 temporal bones from nine fetuses were studied and included seven cases of Down's syndrome and two of Edwards' syndrome. Temporal bones from fetuses with Down's syndrome had more abnormalities of the external and middle ears than of the inner ear. The bones from the fetuses with Edwards' syndrome showed abnormalities of the external or middle ear and retarded development of the inner ear (failed ossification of the otic capsule and unformed organ of Corti). 相似文献
8.
Mirna SuČIĆ Dubravka Boban Mirjana MarkoviĆ-glamoČak Mladen PetroveČki Matko MaruŠIĆ Boris Labar 《Medical oncology (Northwood, London, England)》1992,9(1):41-45
Cytochemical analysis of leukemic blasts from 46 patients with acute myeloblastic M2 leukemia (according to the FAB classification)
was performed before and after cytostatic therapy, and compared with findings obtained in 20 age- and sex-matched control
subjects. Cytochemical findings for myeloperoxidase (MPO), Sudan black B, acid phosphatase and alpha-naphthyl-acetate esterase
(ANAE) were related to the achievement of the first complete remission (CR),i.e. data were compared after the patients had been divided into CR and non-CR groups. The analysis clearly showed that a high
proportion of myeloperoxidase- and, to a lesser extent, Sudan black B-positive blasts before treatment may have constituted
a significantly unfavourable prognostic factor. 相似文献
9.
Martina Plísková Jan Vondrácek Borivoj Vojtesek Alois Kozubík Miroslav Machala 《Toxicological sciences》2005,83(2):246-256
Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (BaP), are carcinogens suggested to be involved in development of human cancer. Several recent studies have reported that PAHs can activate estrogen receptors (ER), either directly or indirectly by producing estrogenic metabolites. We hypothesized that the activation of ER by PAHs or their metabolites could induce cell proliferation in estrogen-sensitive cells. In the present study, we found that two PAHs, benz[a]anthracene (BaA) and BaP, can stimulate proliferation of human breast carcinoma MCF-7 cells at concentrations 100 nM and higher. This effect was ER-dependent, because it was blocked by the pure antiestrogen ICI 182,780. Although both PAHs partially inhibited S-phase entry and DNA synthesis induced by 17beta-estradiol, they stimulated S-phase entry when applied to MCF-7 cells synchronized by serum deprivation. This was in contrast with model antiestrogenic aryl hydrocarbon receptor ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin, which fully suppressed S-phase entry. BaP, which is a strong mutagen, was found to induce p53 tumor suppressor expression, a partial S-phase arrest and at higher concentrations also cell death. Pifithrin-alpha, a synthetic inhibitor of p53 activity, abolished both S-phase arrest and apoptosis induced by genotoxic PAHs, and it potentiated the proliferative effect of BaP. Thus, both genotoxic and nongenotoxic events seem to interact in the effects of BaP on cell proliferation. Taken together, our data indicate that both BaA and BaP can stimulate cell proliferation through activation of ER. The proliferative effects of these carcinogenic compounds might contribute to tumor promotion in estrogen-sensitive tissues. 相似文献
10.
Eva Dragomirecka William R. Lenderking Lucie Motlova Eva Goppoldova Pavla Šelepova 《Quality of life research》2006,15(2):307-312
The Schwartz Outcomes Scale-10 (SOS-10) is a 10-item scale developed to measure the effectiveness of psychiatric treatments.
Using standard methodology, we translated the scale into Czech and examined the psychometric properties of the Czech version.
207 in-patients admitted to Prague Psychiatric Center were included in the study. All patients completed the SOS at admission
and discharge. The SOS-10 scale was also administered to 170 persons from the general population. Reliability, validity and
sensitivity to treatment change of the Czech SOS-10 were analyzed. The Cronbach’s α coefficient was 0.92. The item-total correlation coefficients varied from 0.56 to 0.82. The SOS-10 correlated well with condition-specific
measures including depression (BDI) and anxiety (BAI) and a global self-rated symptom severity scale (CGI). The SOS-10 also
had significant correlations with the Health, Basic needs, Relationship, and Leisure time domains of the Czech version of
the Subjective Quality of Life Analysis (SQUALA-CZ). The scale discriminated well between patients and controls, with patients
scoring significantly lower on all SOS items. The patient sample’s admission and discharge scores were significantly different,
indicating that the scale is sensitive to treatment changes. We concluded that the Czech SOS-10 is valid with reliability
and factor structure similar to the American language version. 相似文献