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R. Kiani 《European journal of clinical microbiology & infectious diseases》1991,10(10):880-884
In this double-blind, randomised trial conducted in 22 centres in the USA, azithromycin given over five days, as a once-a-day regimen, (500 mg on day 1, 250 mg on days 2–5) was compared with cephalexin (500 mg b.i.d.) given for ten days in the treatment of patients with skin and skin structure infections. A total of 366 patients entered the study and 179 of these were eligible for the efficacy analysis. The overall clinical response to azithromycin was 94.0 %, compared with 95.8 % for cephalexin. The clinical cure rates were 53.0 % for azithromycin and 59.4 % for cephalexin; the respective improvement rates were 41.0 % and 36.5 %. Distribution of response (cured, improved, failed) was similar in each group (p=0.37). The bacteriological eradication rate for azithromycin-treated patients was 94.2 % and for cephalexin-treated patients was 90.3 % (p=0.34). Clinical and bacteriological response was similar in each group for all primary diagnoses. The two antibiotics were well tolerated, the overall incidence of side effects being 13.7 % with approximately 60 % due to gastrointestinal disturbances. In all but one case (cephalexin) the severity of the reported side effects was mild or moderate. Six patients withdrew from the study due to treatment-related events; five had been treated with azithromycin and one with cephalexin. In summary, a five-day, once-daily regimen of azithromycin was as effective as a ten-day, twice-daily regimen of cephalexin in the treatment of patients with skin and skin structure infections. 相似文献
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Kiani Zahra Simbar Masoumeh Nazarpour Soheila Rashidi Fakari Farzaneh 《Archives of sexual behavior》2022,51(7):3223-3224
Archives of Sexual Behavior - 相似文献
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Aileen Azari-Yaam Mohammad Reza Abdolsalehi Mohammad Vasei Moeinadin Safavi Mehrzad Mehdizadeh 《Head and neck pathology》2021,15(1):352
Rosai–Dorfman disease (RDD) is a rare and self-limiting disease process that presents most commonly in young patients as massive, painless, cervical lymphadenopathy. Extranodal involvement may also occur. Histopathologic evaluation is the main diagnostic modality. We report an unusual presentation of RDD with cervical lymphadenopathy and an incidentally discovered sinonasal mass, clinically worrisome for malignancy. We emphasize that a high index of clinical suspicion is critical for accurate diagnosis of RDD. Clinicians and pathologists should consider RDD in a differential diagnosis of cervical lymphadenopathy, especially in young patients. 相似文献
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Hadise Kavandi Alireza Khabbazi Sousan Kolahi Mehrzad Hajialilo Farid Karkon Shayan Mohammad Oliaei 《Clinical rheumatology》2016,35(11):2765-2769
Ophthalmic involvement is the most debilitating complication of Behcet’s disease (BD). The aim of the current study is to report on the efficacy and safety of a long-term use of interferon alpha-2a (IFNα-2a) in the treatment of refractory ophthalmic BD in the Azari population of Iran. We retrospectively analyzed the clinical data of 12 patients with ophthalmic BD who were under IFNα-2a therapy. All these patients had previously been treated unsuccessfully with corticosteroid and at least one conventional immunosuppressive drug. IFNα-2a was administered at a daily dose of 6 million IU (MIU). After controlling the symptoms, a dose of 6 MIU three times per week was applied for 8–12 weeks, and then, a dose of 3 MIU was administered three times per week as a subcutaneous injection. Visual acuity and total inflammatory activity index (TIAI) were used in order to assess the response to the treatment. Response to the treatment and complete eye remission were obtained in 10 (83.3 %) and 7 (58.3 %) patients, irrespectively. Improvement or stabilization of visual acuity was observed in 18 (81.8 %) out of 22 eyes. After a mean period of 29.6 months, the use of IFNa-2a was discontinued in eight (66.7 %) patients. Unaltered vision for 2 years after IFNa-2a discontinuation happened in eight (100 %) patients. IFNa-2a is probably effective and safe in the treatment of refractory sight-threatening ophthalmic BD in the Azari population of Iran. 相似文献
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Mitral valve resistance determines hemodynamic consequences of severe rheumatic mitral stenosis and immediate outcomes of percutaneous valvuloplasty
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Participation in pediatric oncology research protocols: Racial/ethnic,language and age‐based disparities
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