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排序方式: 共有444条查询结果,搜索用时 281 毫秒
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2.
P Toussaint P Turut S Milazzo S Le Bihan B Bego 《Bulletin des sociétés d'ophtalmologie de France》1989,89(2):267-8, 271-2
4 cases of tilted disc syndrome are reported. Two were associated with sellar or endocrine pathology, one had a particular aspect of chorioretinal atrophy, and the last had a thrombosis of the central vein of retina. The most commonly aspects of tilted disc syndrome are reported. 相似文献
3.
G Darrason P Turut P Toussaint S Milazzo H Sevestre 《Bulletin des sociétés d'ophtalmologie de France》1989,89(2):325-329
Descending ocular myopathy is a rare progressive disease characterized by bilateral ptosis, external ophthalmoplegia and progressive dystrophy of the proximal skeletal muscles. A case of descending ocular myopathy with post-operative corneal ulceration is reported. Mitochondrial abnormalities are found on skeletal muscle biopsy. Nosologic classification of this case is discussed. 相似文献
4.
S Milazzo P Turut B Bego E Bryselbout 《Bulletin des sociétés d'ophtalmologie de France》1989,89(12):1413-1417
"Like flows" atrophy of the retinal pigment epithelium are observed in multiple cases of lesions of the posterior pole. The authors are reported one observation of different diseases with like flows atrophy. 相似文献
5.
Silvio Buscemi Carola Buscemi Davide Corleo Giovanni De Pergola Rosalia Caldarella Francesco Meli Cristiana Randazzo Salvatore Milazzo Anna Maria Barile Giuseppe Rosafio Valentina Settipani Sabina Gurrera Antonio Maria Borzì Marcello Ciaccio 《Nutrients》2021,13(6)
Background: Vitamin D plays a pivotal role in calcium and phosphorus metabolism, also influencing bone tissue. Several studies have reported that vitamin D blood levels were significantly lower in people with obesity, probably due to its uptake by the adipose tissue. Clinical studies that investigated the changes of circulating levels of vitamin D following weight loss reported controversial data. A very low-calorie ketogenic diet is acknowledged as a reliable treatment to achieve a rapid weight loss. Therefore, we investigated the effect of weight loss, consequent to a very low-calorie ketogenic diet, on vitamin D blood concentrations. Methods: A cohort of 31 people with obesity underwent a very low-calorie ketogenic diet for 10–12 weeks. The serum concentrations of vitamin D, parathormone, calcium and phosphorous were measured before and after weight loss; they were compared to a control group of 20 non-obese, non-diabetic, age- and gender-matched persons. Results: Patients with obesity had a higher habitual intake of vitamin D than the control group (p < 0.05). However, the vitamin D blood levels of the obese group were significantly lower than those of the control group (p < 0.005) and they increased after weight loss (p < 0.001). At baseline, vitamin D blood concentrations of the persons with obesity were significantly correlated with both fat mass–kg (r = −0.40; p < 0.05) and body mass index (r = −0.47; p < 0.01). Following very low-calorie ketogenic diet, the change in vitamin D serum concentrations was correlated only with the change in fat mass–kg (r = −0.43; p < 0.01). Conclusion: This study confirmed that patients with obesity have lower vitamin D levels that normalize after significant weight loss, supporting the hypothesis that vitamin D is stored in the adipose tissue and released following weight loss. 相似文献
6.
Jean-Christophe Zech Laurette Morlé Pascale Vincent Nicole Alloisio Muriel Bozon Colette Gonnet Solange Milazzo Jean-Daniel Grange Christiane Trepsat Jacqueline Godet Henri Plauchu 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1999,237(5):387-393
· Background: It has been previously described that Wagner disease is linked to chromosome 5q13-q14. This study was carried
out to describe the ophthalmological aspects and report the results of genetic linkage analysis in a large pedigree affected
by Wagner disease. · Methods: Fourty members of one same family agreed to be examined. · Results: Twenty patients presented
vitreoretinal degeneration in both eyes without any extra-ocular abnormalities. In young patients, visual acuity was usually
normal after correction of frequent mild myopia. Presenile cataracts progressed by the third decade and required removal for
visual rehabilitation. The primary disorder involved an abnormal vitreous. A few avascular vitreous bands were usually the
only optical feature in the mostly empty vitreous cavity. A circumferential vitreous condensation formed in contact with the
retina on many spots. Less common retinal findings included retinal detachment, abnormal retinal pigmentation, progressive
atrophy of the RPE simulating choroideremia and lattice degeneration. Genetic analysis revealed a highly significant linkage
(lod score >5.0) between the disease and 10 markers of the chromosome 5q13-q14 region. Two recombination events allowed us
to refine the linked interval to 20 cM between the D5S650 and D5S618 markers. · Conclusion: Ophthalmological aspects of Wagner’s
disease appear to progress with age. Regular ophthalmological examination is important for detecting retinal abnormalities.
The gene involved in Wagner’s disease lies in a 20 cM interval on chromosome 5q13-q14.
Received: 30 June 1998 Revised version received: 5 October 1998 Accepted: 6 October 1998 相似文献
7.
Jean-Yves Driot Gary D Novack Kay D Rittenhouse Chris Milazzo P Andrew Pearson 《Journal of ocular pharmacology and therapeutics》2004,20(3):269-275
PURPOSE: The present study was designed to examine the pharmacokinetics of a fluocinolone acetonide (FA) intravitreal implant in pigmented rabbits. METHODS: Pigmented rabbits were randomly assigned to receive either a 0.5 mg or 2.0 mg FA intravitreal implant (Retisert). Four animals were sacrificed per time point (2 hours; 2 weeks; and 3, 6, 9, and 12 months after implantation) for FA intraocular levels determination. RESULTS: In the vitreous, concentration of FA was relatively constant from the first time point, 2 hours, through 1 year, and dose-related, approximately seven- to eight-fold greater in the 2-mg implant. Concentrations of FA were generally higher in the vitreous (11-18 and 75-146 ng/g) and retina (42-87 and 224-489 ng/g) than in the aqueous humor (0.21-1.1 and 2.6-13.0 ng/g) for the 0.5- and 2-mg implants, respectively. Urine and plasma values were below the lower limit of quantitation (200 pg/mL) for all observations, indicating no evidence of systemic absorption. CONCLUSIONS: In this rabbit study, the Retisert provides relatively constant levels of FA in the posterior pole, which is consistent with previous reports of its clinical utility. 相似文献
8.
Maria N.B. Cajimat Mary Louise Milazzo Matthew R. Mauldin Robert D. Bradley Charles F. Fulhorst 《Virus research》2013
The southern plains woodrat (Neotoma micropus) is the principal host of Catarina virus in southern Texas and a natural host of other North American Tacaribe serocomplex viruses. The objectives of this study were to increase our knowledge of the genetic diversity among Tacaribe serocomplex viruses associated with N. micropus and to define better the natural host relationships of these viruses. Pairwise comparisons of complete glycoprotein precursor gene sequences and complete nucleocapsid protein gene sequences revealed a high level of genetic diversity among Tacaribe serocomplex viruses associated with N. micropus in western Oklahoma, southern New Mexico, and northern and southern Texas. Collectively, the results of Bayesian analyses of nucleotide sequences and pairwise comparisons of amino acid sequences confirmed that the arenaviruses associated with N. micropus in Oklahoma and New Mexico should be included in the Whitewater Arroyo species complex, and indicated that that the arenaviruses associated with N. micropus in northern Texas are strains of a novel arenaviral species – tentatively named “Middle Pease River virus”. Together, the results of assays for arenavirus and assays for anti-arenavirus antibody in 54 southern plains woodrats and 325 other rodents captured at 2 localities suggested that the southern plains woodrat is the principal host of Middle Pease River virus in northern Texas. 相似文献
9.
Carissa M. Baker-Smith MD Angelo S. Milazzo MD Donald P. Frush MD James Jaggers MD Margaret L. Kirby MD Ronald J. Kanter MD Piers C. Barker MD 《Congenital heart disease》2010,5(3):316-320
Aortic valve atresia with interruption of the aortic arch is an extremely rare anomaly; only eleven cases of this anomaly have been reported to date. In the absence of additional sources of blood flow to the ascending aorta, aortic valve atresia with interruption of the aortic arch is fatal. We present, to the best of our knowledge, the first case of a live birth with aortic valve atresia and interrupted left aortic arch (type B) without evidence of an aorticopulmonary communication or ductal supply to the native ascending aorta. Instead, blood flow to the native aortic root was derived from a persistent right embryonic dorsal aorta. 相似文献
10.
The sodium(Na)- and potassium(K)-activated adenosine-triphosphatase (Na,K-ATPase) is a membrane enzyme that energizes the Na-pump by hydrolysing adenosine triphosphate and wasting energy as heat, so playing a role in thermogenesis and energy balance. Na,K-ATPase regulation by insulin is controversial; in tissue of hyperglycemic-hyperinsulinemic ob/ob mice, we reported a reduction, whereas in streptozotocin-treated hypoinsulinemic-diabetic Swiss and ob/ob mice we found an increased activity, which is against a genetic defect and suggests a regulation by hyperinsulinemia. In human adipose tissue from obese patients, Na,K-ATPase activity was reduced and negatively correlated with body mass index, oral glucose tolerance test-insulinemic area and blood pressure. We hypothesized that obesity is associated with tissue Na,K-ATPase reduction, apparently linked to hyperinsulinemia, which may repress or inactivate the enzyme, thus opposing thyroid hormones and influencing thermogenesis and obesity development. Insulin action on Na,K-ATPase, in vivo, might be mediated by the high level of non-esterified fatty acids, which are circulating enzyme inhibitors and increase in obesity, diabetes and hypertension. In this paper, we analyse animal and human tissue Na,K-ATPase, its level, and its regulation and behaviour in some hyperinsulinemic and insulin-resistant states; moreover, we discuss the link of the enzyme with non-esterified fatty acids and attempt to interpret and organize in a coherent view the whole body of the exhaustive literature on this complicated topic. 相似文献