3,4-Bis(3′-hydroxyphenyl)hexane — A new mammary tumor-inhibiting compound

Summary The syntheses of the hexestrol derivatives 3,4-bis-(3-hydroxyphenyl)hexane (4a), 3,4-bis(4-fluoro-3-hydroxyphenyl)hexane (4b), 3,4-bis(3, 4dihydroxyphenyl)hexane (4c), and 3,4-bis(3,4-diacetoxyphenyl)hexane (4d) are described. All compounds showed a marked, competitive inhibition of the estradiol receptor interaction (K _a4c>K_a4a>K_a4d>K_a4b). Evaluated in the mouse uterine weight test compounds 4c and 4d almost reached the estrone effect, whereas 4a and 4b did not produce full uterotrophic response. Compounds 4a-d antagonized the estrone stimulated uterine growth of the immature mouse. Compound 4a (NSC-297170) exhibited a specific, dose-related growth inhibition of the estrogen responsive MCF-7 human breast tumor cell line. Tested on the 9,10-dimethyl-1,2-benzanthracene-induced hormonedependent mammary adenocarcinoma of the Sprague-Dawley rat all compounds showed marked inhibition of tumor growth. As in all experiments compounds 4a and 4b, which is resistant to hydroxylation in 4position exhibited an identical pattern of action, which is different from that shown by compound 4c, the effect of compound 4a cannot be explained by its possible catechol metabolite 4c.Supported by grants from the Deutsche Forschungsgemeinschaft and the Verband der Chemischen Industrie-Fonds der Chemischen Industrie     

Technische und digitale Weiterentwicklung in der laparoskopischen/offenen Chirurgie

Technological innovations have initiated a fundamental change in invasive therapeutic approaches which has led to a welcome reduction of surgical trauma but was also associated with a declining role of conventional surgery. Active utilization of future technological developments is decisive to promote new therapeutic strategies and to avoid a further loss of importance of surgery. This includes individualized preoperative therapy planning as well as intraoperative diagnostic work-up and navigation and the use of new functional intelligent implants. The working environment “surgical operating room” has to be refurbished into an integrated cooperating functional system. The impact of new technological developments is particularly obvious in minimally invasive surgery. There is a clear tendency towards further reduction in trauma in the surgical access. The incision will become smaller and the number of ports will be further reduced, with the aim of ultimately having just one port (monoport surgery) or even via natural access routes (scarless surgery). Among others, improved visualization including, e.g. autostereoscopy, digital image processing and intelligent support systems, which are able to assist in a cooperative way, will enable these goals to be achieved.     

The route of administration (oral vs intravenous) does not influence dose or outcome in Graves’ disease and unifocal autonomy

Purpose In a prospective randomised study, we investigated the influence of the route of administration of radioiodide on dosimetry and therapy outcome.Methods Fifty-four patients suffering from Graves disease (GD) and 60 patients with unifocal autonomy (UA) participated in the study and were randomly treated with either orally or intravenously administered radioiodide. Pretherapeutic dosimetry was based on single uptake measurements with a calibrated uptake probe system. The radioiodine kinetics during hospitalisation was assessed by daily bedside uptake measurements. Therapeutic dose was determined by half-life and thyroid uptake at the time of discharge using the same uptake probe as for the radioiodine test.Results No improvement in accuracy of dosimetry was achieved when radioiodide was administered intravenously. Mean therapeutic doses were identical following intravenous or oral administration. Variation in the achieved dose was slightly higher in the patients receiving oral administration, this being attributable to larger deviations in discrete activities of the capsules administered as compared with the values determined by dosimetry. No differences according to treatment modality were found with regard to therapeutic outcome. Eighty-seven patients attended 6-month follow-up after therapy. In the UA group, successful treatment, defined as a normal or elevated TSH level, was observed in 94% of patients after oral administration and in 80% after intravenous administration; corresponding figures in the GD group were 68% and 65%.Conclusion The causes of individual differences between targeted and therapeutically achieved doses remain undetermined. Variations in the bioavailability of radioiodide or other parameters affecting thyroid status may be involved, and further investigations are needed to clarify this.     

Superfetation occurring in connection with gamete intrafallopian transfer: a case report

This observation reports a case of superfetation which occurred in connection with gamete intrafallopian transfer (GIFT). The macroscopic and histological examination of a spontaneous abortion from a 33-year-old woman (15th week of pregnancy) revealed the existence of two embryos with a monochorionic diamniotic placenta (developmental age approximately 41 days) and two fetuses and a fetal remnant with a trichorionic and triamniotic placenta (developmental age approximately 98 days). The large developmental age difference of embryos and fetuses cannot be explained by retardation, because the embryos showed adequate development with the development of their placenta. Moreover, the usual causes of intrauterine growth retardation could be excluded as could retention of the embryos since the tissues showed no autolytic changes. Consequently the large developmental age difference is explained by assuming that the embryos developed from successive ovulations. A second nidation of blastocysts had occurred after the GIFT concurrently with the clinically reported hyperstimulation syndrome.     

Kolporrhaphia anterior und Urethrovesicopexie nach Bruch Eine prospektive Studie anamnestischer und tonometrischer Befunde

Zusammenfassung Aufbauend auf eine standardisierte pr?operative Harninkontinenzdiagnostik führt die selektive Auswahl eines abdominalen oder vaginalen Operationsverfahrens zu einem guten Therapieerfolg. Der Beobachtungszeitraum von 4 Jahren zeigt erfreulicherweise, da? sich das erzielte Operationsergebnis in den Folgejahren nur gering verschlechtert.     

Zur Erfolgsbeurteilung von Inkontinenzoperationen. Analyse prä- und postoperativ erhobener morphologischer und funktioneller Befunde

Urodynamic and morphologic findings in 82 patients with stress urinary incontinence were analysed. All patients had undergone vaginal respectively abdominal hysterectomy with anterior colporrhaphy respectively urethrovesicopexy. Whereas in the abdominal group the urodynamic and morphologic findings improved significantly, this did not occur in the vaginal group (Colp. ant. group). Although a comparison of the postoperatively continent patients with the recurrent incontinence patients showed no significant difference, it seemed, however, that the recurrent incontinence patients frequently showed lower urodynamic and morphologic values.     

Die Wertigkeit der Endometrium-Zytologie (Endozyte) im Rahmen der gynäkologischen Krebsvorsorgeuntersuchung

Ohne Zusammenfassung     

Mammatumorhemmende Antiöstrogene vom Typ des 3,3′-Dihydroxy-α,β-dialkylstilbens

Mammary Tumor Inhibiting Antiestrogens of the 3,3′-Dihydroxy-α,β-dialkylstilbene Type. The trans-3,3′-dihydroxy-α,β-dialkylstilbenes 1, 3–5 are antiestrogens with a marked effect on the DMBA-induced hormone dependent mammary carcinoma of the SD-rat (especially 3 and 4 ). They are synthesized by reaction of (3-methoxyphenyl)diazoalkanes c with SO₂ to give 1,1-dioxo-2,5-dialkyl-2,5-bis-(3-methoxyphenyl)-Δ³-1,3,4-thiadiazolines d . Thermal decomposition yields the 3,3′-dimethoxy-α,β-dialkylstilbenes e which are then subjected to ether cleavage.