全文获取类型
收费全文 | 39459篇 |
免费 | 2260篇 |
国内免费 | 165篇 |
专业分类
耳鼻咽喉 | 504篇 |
儿科学 | 715篇 |
妇产科学 | 793篇 |
基础医学 | 5102篇 |
口腔科学 | 1458篇 |
临床医学 | 3182篇 |
内科学 | 9287篇 |
皮肤病学 | 880篇 |
神经病学 | 2905篇 |
特种医学 | 1523篇 |
外科学 | 6484篇 |
综合类 | 503篇 |
一般理论 | 8篇 |
预防医学 | 1705篇 |
眼科学 | 598篇 |
药学 | 2590篇 |
中国医学 | 48篇 |
肿瘤学 | 3599篇 |
出版年
2022年 | 374篇 |
2021年 | 698篇 |
2020年 | 330篇 |
2019年 | 538篇 |
2018年 | 718篇 |
2017年 | 515篇 |
2016年 | 585篇 |
2015年 | 687篇 |
2014年 | 931篇 |
2013年 | 1084篇 |
2012年 | 1703篇 |
2011年 | 1807篇 |
2010年 | 1028篇 |
2009年 | 974篇 |
2008年 | 1687篇 |
2007年 | 1778篇 |
2006年 | 1820篇 |
2005年 | 1856篇 |
2004年 | 1762篇 |
2003年 | 1709篇 |
2002年 | 1670篇 |
2001年 | 1367篇 |
2000年 | 1554篇 |
1999年 | 1349篇 |
1998年 | 516篇 |
1997年 | 364篇 |
1996年 | 362篇 |
1995年 | 336篇 |
1994年 | 304篇 |
1993年 | 276篇 |
1992年 | 891篇 |
1991年 | 831篇 |
1990年 | 744篇 |
1989年 | 756篇 |
1988年 | 744篇 |
1987年 | 726篇 |
1986年 | 750篇 |
1985年 | 656篇 |
1984年 | 489篇 |
1983年 | 409篇 |
1979年 | 372篇 |
1978年 | 284篇 |
1977年 | 237篇 |
1975年 | 235篇 |
1974年 | 262篇 |
1973年 | 236篇 |
1972年 | 226篇 |
1971年 | 239篇 |
1970年 | 241篇 |
1969年 | 257篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Xiying Fan Glen A. Bjerke Kent Riemondy Li Wang Rui Yi 《Molecular carcinogenesis》2019,58(12):2241-2253
MicroRNAs (miRNAs) play important roles in prostate cancer development. However, it remains unclear how individual miRNAs contribute to the initiation and progression of prostate cancer. Here we show that a basal layer‐enriched miRNA is required for prostate tumorigenesis. We identify miR‐205 as the most highly expressed miRNA and enriched in the basal cells of the prostate. Although miR‐205 is not required for normal prostate development and homeostasis, genetic deletion of miR‐205 in a Pten null tumor model significantly compromises tumor progression and does not promote metastasis. In Pten null basal cells, loss of miR‐205 attenuates pAkt levels and promotes cellular senescence. Furthermore, although overexpression of miR‐205 in prostate cancer cells with luminal phenotypes inhibits cell growth in both human and mouse, miR‐205 has a minimal effect on the growth of a normal human prostate cell line. Taken together, we have provided genetic evidence for a requirement of miR‐205 in the progression of Pten null‐induced prostate cancer. 相似文献
2.
3.
Toshihiro Yoshitake Akira Takeda Kensaku Ohki Yuko Inoue Takanori Yamawaki Saori Otsuka Minekatsu Akimoto Mitsuru Nemoto Yasuhito Shimakura Akio Sato 《The Journal of dermatology》2015,42(7):735-738
Finasteride is standard medical treatment for androgenetic alopecia; however, no large studies with 5 years or more of follow up have been performed in Japan. The authors followed Japanese men with androgenetic alopecia treated with finasteride for 5 years to evaluate long‐term treatment efficacy. Of 903 men treated with finasteride (1 mg/day), 801 patients were evaluated over 5 years by modified global photographic assessment. Although the proportion of improvement was high (99.4%), modified global photographic assessment scores after 5 years of treatment were lower in patients with more advanced disease as measured by the modified Norwood–Hamilton scale. After separating patients into “sufficient” and “insufficient” efficacy groups according to the modified global photographic assessment score after 5 years (scores ≥6 and <6, respectively), multivariate analysis showed that independent risk factors of insufficient efficacy were age at start of treatment of 40 years or more (P = 0.021) and classification on the modified Norwood–Hamilton scale (P < 0.001), whereas presence of stress at start of treatment was a negative predictor (P = 0.025). In conclusion, continuous finasteride treatment for 5 years improved androgenetic alopecia with sustained effect among Japanese. Younger age and less advanced disease at start of treatment were the key predictors of higher finasteride efficacy. 相似文献
4.
James Milligan Joseph Lee Matt Smith Lindsay Donaldson Peter Athanasopoulos Kent Bassett-Spiers 《The journal of spinal cord medicine》2020,43(2):223-233
Context: Persons with spinal cord injury (SCI) experience significant challenges when they access primary care and community services.Design: A provincial summit was held to direct research, education, and innovation for primary and community care for SCI.Setting: Toronto, Ontario, Canada.Participants: Key stakeholders (N?=?95) including persons with SCI and caregivers, clinicians from primary care, rehabilitation, and specialized care, researchers, advocacy groups, and policy makers.Methods: A one-day facilitated meeting that included guest speakers, panel discussions and small group discussions was held to generate potential solutions to current issues related to SCI care and to foster collaborative relationships to advance care for SCI. Perspectives on SCI management were shared by primary care, neurosurgery, rehabilitation, and members of the SCI communityOutcome Measures: Discussions were focused on five domains: knowledge translation and dissemination, application of best practices, communication, research, and patient service accessibility.Results: Summit participants identified issues and prioritized solutions to improve primary and community care including the creation of a network of key stakeholders to enable knowledge creation and dissemination; an online repository of SCI resources, integrated health records, and a clinical network for SCI care; development and implementation of strategies to improve care transitions across sectors; implementation of effective care models and improved access to services; and utilization of empowerment frameworks to support self-management.Conclusions: This summit identified priorities for further collaborative efforts to advance SCI primary and community care and will inform the development of a provincial SCI strategy aimed at improving the system of care for SCI. 相似文献
5.
6.
7.
Marcelo Sato‐Sano Solange Pistori Teixeira Juliano Cordova Vargas Otvio Cesar Carvalho Guimares Baiocchi Milvia Maria Simes e Silva Enokihara Elimar Elias Gomes Mariana Dias Batista 《The Journal of dermatology》2019,46(7):618-621
Eosinophilic dermatosis of hematological malignancy is a paraneoplastic skin eruption associated with chronic lymphocytic leukemia and other B‐cell malignancies. It clinically resembles an insect bite reaction and it can precede the symptoms of the hematological malignancy or be related to a more aggressive course. Different treatments have been proposed, but partial response and recurrence are frequent. Herein, we describe a case of eosinophilic dermatosis associated with mantle cell lymphoma with remission after lenalidomide therapy. 相似文献
8.
9.
10.