全文获取类型
收费全文 | 1366篇 |
免费 | 71篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 42篇 |
妇产科学 | 38篇 |
基础医学 | 235篇 |
口腔科学 | 31篇 |
临床医学 | 133篇 |
内科学 | 237篇 |
皮肤病学 | 24篇 |
神经病学 | 105篇 |
特种医学 | 96篇 |
外国民族医学 | 1篇 |
外科学 | 169篇 |
综合类 | 33篇 |
预防医学 | 112篇 |
眼科学 | 24篇 |
药学 | 99篇 |
中国医学 | 3篇 |
肿瘤学 | 53篇 |
出版年
2023年 | 14篇 |
2022年 | 53篇 |
2021年 | 64篇 |
2020年 | 38篇 |
2019年 | 43篇 |
2018年 | 51篇 |
2017年 | 34篇 |
2016年 | 32篇 |
2015年 | 43篇 |
2014年 | 57篇 |
2013年 | 86篇 |
2012年 | 94篇 |
2011年 | 92篇 |
2010年 | 56篇 |
2009年 | 40篇 |
2008年 | 68篇 |
2007年 | 63篇 |
2006年 | 60篇 |
2005年 | 46篇 |
2004年 | 62篇 |
2003年 | 57篇 |
2002年 | 70篇 |
2001年 | 19篇 |
2000年 | 9篇 |
1999年 | 11篇 |
1998年 | 12篇 |
1997年 | 13篇 |
1996年 | 13篇 |
1995年 | 10篇 |
1994年 | 8篇 |
1993年 | 7篇 |
1992年 | 9篇 |
1991年 | 17篇 |
1990年 | 20篇 |
1989年 | 22篇 |
1988年 | 9篇 |
1987年 | 4篇 |
1986年 | 8篇 |
1985年 | 4篇 |
1984年 | 6篇 |
1981年 | 2篇 |
1980年 | 6篇 |
1977年 | 2篇 |
1969年 | 1篇 |
1967年 | 2篇 |
1966年 | 1篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1962年 | 2篇 |
1961年 | 1篇 |
排序方式: 共有1447条查询结果,搜索用时 0 毫秒
1.
2.
Huda Mohammed Alkreathy Mayson H. Alkhatib Safaa Ahmed Al Musaddi Khadijah Saeed A. Balamash Nadia Nour Osman Aftab Ahmad 《Clinical and experimental pharmacology & physiology》2019,46(5):496-505
Doxorubicin (DOX) is the most commonly used anticancer drug; however, it has limited use because prolonged administration may result in severe cardiotoxicity. Simvastatin (SIM), generally prescribed for hypercholesterolaemia, has also shown salubrious results in the monotherapy or combinational drug therapy of different cancers in various models. Nanoparticle drug delivery systems are a novel way of improving therapeutics and also improving the absorption and specificity of drugs towards tumour cells. In this study, we exploited this technology to increase drug specificity and minimize imminent adverse effects. In this study, the antitumour activity of the combination formulas of DOX and SIM, either loaded in water (DOX‐SIM‐Solution) or nanoemulsions (NEs) (DOX‐SIM‐NE), was evaluated in a Swiss albino mouse model of Ehrlich ascites carcinoma. The anticancer effect was assessed by quantifying the change in body weight, mean survival time, and percent increase in lifespan (%ILS), determining haematological and serum biochemical parameters (liver function test, kidney function test and lipid profile parameters) as well as studying the histopathological alterations in liver tissues. We observed a clear increase in %ILS of the DOX‐SIM‐Solution group (265.30) that was double the %ILS of the DOX‐SIM‐NE group (134.70). However, DOX‐SIM‐NE had a non‐toxic effect on the haematological parameters, whereas DOX‐SIM‐Solution increased the levels of haemoglobin and lymphocytes. Furthermore, the encapsulation of SIM and DOX into NEs improved the levels of all serum biochemical parameters compared to the DOX‐SIM‐Solution. A reduction in the side effects of DOX‐SIM‐NE on the liver was also established using light microscopy, which revealed that the morphologies of the hepatocytes of the mice were less affected by administration of the DOX‐SIM‐NE treatment than with the DOX‐SIM‐Solution treatment. The study showed that incorporating SIM into the DOX‐loaded‐NE formulation remarkably improved its efficiency and simultaneously reduced its adverse effects. 相似文献
3.
4.
5.
6.
Concomitant administration of cyclosporine and ketoconazole in idiopathic nephrotic syndrome. 总被引:1,自引:1,他引:0
Amr El-Husseini Fathy El-Basuony Ahmed Donia Ihab Mahmoud Nabil Hassan Nagy Sayed-Ahmad Mohamed Sobh 《Nephrology, dialysis, transplantation》2004,19(9):2266-2271
BACKGROUND: The deliberate use of ketoconazole to reduce the need for cyclosporine (CsA) is not new, but it is particularly relevant because of the high cost of CsA. Many studies have documented this benefit in renal and cardiac transplants, but this co-administration has not been reported in patients with nephrotic syndrome. METHODS: This retrospective study included 207 nephrotic patients who were steroid resistant, dependent or frequent relapsers and received CsA therapy. Among these patients 153 received daily ketoconazole therapy in a dose of 50 mg with concomitant decrease of one-third of the CsA dose while 54 patients received CsA alone. The majority of our cases were children (179 were below 18 years) and male to female ratio was 1.7:1. RESULTS: The great majority of the study population received the drugs for 1-2 years. Patients who received CsA and ketoconazole were comparable with those who received CsA alone regarding age, sex, duration of renal disease, renal pathology, severity of nephrotic syndrome, renal function, hepatic function and steroid response. Co-administration of ketoconazole significantly reduced mean doses of CsA by 37% after 1 month and 47% at 1 year with overall net cost savings of 37%. Hepatic functions remained within the normal range in both groups. Additionally, co-administration of ketoconazole significantly improved the response to CsA therapy, successful steroid withdrawal and decreased the frequency of renal impairment. CONCLUSIONS: Co-administration of keto with CsA in idiopathic nephrotic patients significantly reduces CsA costs and may improve its response. 相似文献
7.
Decision-making and paediatric pain: a review 总被引:1,自引:0,他引:1
The aim of this paper is to present an overview of the literature on the factors influencing decision-making the nursing care of children in pain. To that effect published and unpublished references werr reviewed. The most frequently cited factors influencing the assessment and management of pain in children are summarized and discussed. Finally recommendations are made where further research is warranted. 相似文献
8.
Ireen M. Proot Harry F. J. M. Crebolder Huda Huijer Abu-Saad Ruud H. J. Ter Meulen 《Scandinavian journal of caring sciences》1998,12(3):139-145
This article presents a concept analysis of autonomy in relation to the rehabilitation of stroke patients. Analysis of the results of a literature survey provided three important concepts of autonomy in the field of biomedical ethics: self-governance, self-realization and actual autonomy. These concepts are compared with concepts from caring sciences and summarized in a table. The results indicate the importance of the social environment (formal and informal caregivers) for the restoration of autonomy. Because of the patient's condition and context, a social concept of autonomy makes more sense in the rehabilitation of stroke patients in nursing homes than does an individual concept. The concept analysis sheds light on the fact that the majority of studies regarding patient autonomy are primarily based on theoretical reflections, not on empirical studies. More research is warranted to gather information on how patients themselves consider and appreciate autonomy during rehabilitation, to explore the views of stroke patients' formal and informal caregivers and to investigate whether a social concept of autonomy is suitable for all phases of rehabilitation. Concerning the practice of rehabilitation, no definite conclusion can be given as yet. 相似文献
9.
10.
Irradiation of volunteers in nuclear medicine 总被引:1,自引:0,他引:1
The preliminary assessment of many radiopharmaceuticals is often carried out with the help of "normal volunteers". These volunteers are drawn from the general public, are fully informed of the procedure to be performed and its attendant risks, and in many cases are compensated financially for their trouble. The cooperation of such people is of vital importance to the full understanding of the normal kinetics and metabolism of many new radiopharmaceuticals. The restrictions on the choice of normal volunteers, and the radiation dose limits which must be observed are not explicitly defined in any of the current guidelines, and in this paper we propose a rationale, based upon available information, which sets acceptable limits for volunteers, and provides a framework within which scientists and physicians can work. 相似文献