全文获取类型
收费全文 | 2238篇 |
免费 | 341篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 77篇 |
妇产科学 | 287篇 |
基础医学 | 153篇 |
口腔科学 | 30篇 |
临床医学 | 885篇 |
内科学 | 303篇 |
皮肤病学 | 82篇 |
神经病学 | 36篇 |
特种医学 | 250篇 |
外科学 | 103篇 |
综合类 | 57篇 |
一般理论 | 1篇 |
预防医学 | 128篇 |
眼科学 | 7篇 |
药学 | 85篇 |
肿瘤学 | 97篇 |
出版年
2023年 | 46篇 |
2022年 | 5篇 |
2021年 | 19篇 |
2020年 | 41篇 |
2019年 | 28篇 |
2018年 | 68篇 |
2017年 | 100篇 |
2016年 | 87篇 |
2015年 | 120篇 |
2014年 | 113篇 |
2013年 | 115篇 |
2012年 | 70篇 |
2011年 | 95篇 |
2010年 | 127篇 |
2009年 | 122篇 |
2008年 | 70篇 |
2007年 | 81篇 |
2006年 | 61篇 |
2005年 | 44篇 |
2004年 | 26篇 |
2003年 | 37篇 |
2002年 | 40篇 |
2001年 | 49篇 |
2000年 | 20篇 |
1999年 | 59篇 |
1998年 | 100篇 |
1997年 | 115篇 |
1996年 | 109篇 |
1995年 | 96篇 |
1994年 | 67篇 |
1993年 | 51篇 |
1992年 | 31篇 |
1991年 | 30篇 |
1990年 | 18篇 |
1989年 | 39篇 |
1988年 | 38篇 |
1987年 | 26篇 |
1986年 | 30篇 |
1985年 | 36篇 |
1984年 | 19篇 |
1983年 | 15篇 |
1982年 | 21篇 |
1981年 | 14篇 |
1980年 | 16篇 |
1979年 | 6篇 |
1978年 | 17篇 |
1977年 | 15篇 |
1976年 | 13篇 |
1975年 | 14篇 |
1970年 | 2篇 |
排序方式: 共有2587条查询结果,搜索用时 15 毫秒
1.
2.
D Van Neste† RM Trüeb‡ 《Journal of the European Academy of Dermatology and Venereology》2006,20(5):578-583
BACKGROUND: Computer-assisted image analysis has been proposed for human hair growth studies. METHODS: The performances of Trichoscan, a commercially available automated system combining epiluminiscence microscopy with digital image analysis, developed for office-based hair growth measurements, have been evaluated comparatively on the same skin sites using standardized photographic equipment and calibrated processing for contrast-enhanced phototrichogram (CE-PTG) analysis. This reference method has been validated with scalp biopsies and histological examination of serial sectioning. RESULTS: Besides edge effects, hair fibres escaped the Trichoscan analysis for various reasons including, but not limited to, thickness, pigmentation, closeness and crossing. CONCLUSION: Most of these problems have been identified in the late 1980s and remain largely unsolved by the processing software that was evaluated in 2004. Therefore claims promoting the Trichoscan method for accurate hair measurements in clinical trials on scalp and body hair are not supported by the present investigation. The speed at which the analysis is performed is outweighed by the errors in signal detection. Therefore we suggest that improvements must be clearly documented before Trichoscan is established for quantified diagnostic purposes and detailed hair cycle monitoring during hair trials. 相似文献
3.
Henk R Franke F Froukje Snaaijer Paul W H Houben Marius J van der Mooren 《Gynecological endocrinology》2006,22(12):692-697
OBJECTIVE: To assess the effects of adding combined estradiol/norethisterone acetate therapy (CENT) to goserelin acetate treatment (GA) of dysfunctional uterine bleeding (DUB) in perimenopausal women. METHODS: In a randomized, placebo-controlled, double-blind trial followed by an open follow-up study, 31 perimenopausal women with DUB were recruited from gynecological outpatient departments of two Dutch hospitals and randomized for treatment with either GA/placebo or GA/CENT for 6 months followed by 18 months of GA/CENT for all. The main outcome measures were abdominal pain, number of bleeding days, double-layer endometrial thickness (DET), Greene climacteric score (GCS), visual analog scale for well-being, bone mineral density (BMD) and mammographic density (BI-RAD score). RESULTS: Abdominal pain, number of bleeding days and DET decreased in both groups, the between-group difference in decrease not being statistically significant. GCS initially showed significant improvement in the GA/CENT group. BMD decreased significantly in the GA/placebo group (-4.1%) compared with the GA/CENT group (-0.3%). Another 18 months of GA/CENT did not result in a lasting difference in BMD between groups. BI-RAD scores did not differ significantly between or within the two groups. CONCLUSIONS: Adding CENT to GA treatment for DUB in perimenopausal women initially prevented BMD loss and improved climacteric complaints, while having no negative impact on vaginal bleeding, abdominal pain or BI-RAD scores. However, prolonged treatment did not result in a lasting prevention of bone loss. 相似文献
4.
5.
V Schleyer† S Radakovic-Fijan‡ S Karrer† T Zwingers§ A Tanew‡ M Landthaler† RM Szeimies† 《Journal of the European Academy of Dermatology and Venereology》2006,20(7):823-828
BACKGROUND: Based on good results in the treatment of superficial skin tumours, since the early 1990s topical photodynamic therapy with aminolaevulinic acid (ALA PDT) has been used for disseminated, inflammatory dermatoses including psoriasis. However, there is still a lack of well-documented trials. OBJECTIVE: A prospective randomized, double-blind phase I/II intrapatient comparison study was conducted in 12 patients to investigate whether topical ALA PDT is an effective treatment for chronic plaque-type psoriasis. METHODS: In each patient three psoriatic plaques were randomly treated with a light dose of 20 J/cm(2) and 0.1%, 1% and 5% ALA, respectively. Treatment was conducted twice a week until complete clearance or for a maximum of 12 irradiations. Therapeutic efficacy was assessed by weekly determination of the psoriasis severity index (PSI). RESULTS: The mean percentage improvement was 37.5%, 45.6% and 51.2% in the 0.1%, 1% and 5% ALA-treated groups, respectively. Irradiation had to be interrupted several times because of severe burning and pain sensation. CONCLUSION: Topical ALA PDT did not prove to be an appropriate treatment option for plaque-type psoriasis due to disappointing clinical efficacy, the time-consuming treatment procedure and its unfavourable adverse event profile. 相似文献
6.
7.
8.
9.
M.M. Bialoskurski MA RN RM C.L. Cox MSc PhD RN & R.D. Wiggins PhD 《Journal of advanced nursing》2002,37(1):62-69
AIM: The aim of this study was to investigate the nature and organization of maternal needs and priorities in a neonatal unit. BACKGROUND: The relationship between maternal needs and priorities appears to be an under studied area in neonatal nursing. METHODS: A quantitative survey was carried out based on 209 mothers with premature infants. Two self-assessment schedules were used: critical care maternal needs inventory (J. Leske, Heart and Lung 15, 27-42) and a ranking scale. The data were analysed with multivariate analysis. FINDINGS: Data analysis revealed clear priorities in maternal needs. In particular the need for accurate infant related information was a priority for 93% of the mothers. Good communication practices with professionals were also valued. The mothers displayed altruistic behaviour, and self-related needs took second place. It is proposed that maternal needs demonstrate a hierarchical organization. CONCLUSION: It is important for nurses to consider the individual needs of the mothers, simply because the satisfaction of these needs is essential for maternal well-being. 相似文献
10.