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排序方式: 共有86条查询结果,搜索用时 140 毫秒
1.
Lovely Chhabra Ramprakash Devadoss Vinod K Chaubey David H Spodick 《Current Cardiology Reviews》2014,10(3):181-189
Interatrial block (IAB; P-wave duration ≥ 110 ms), which represents a delay in the conduction between the atria, is a pandemic conduction abnormality that is frequently underappreciated in clinical practice. Despite its comprehensive documentation in the medical literature, it has still not received adequate attention and also not adequately described and discussed in most cardiology textbooks. IAB can be of varying degrees and classified based on the degree of P-duration and its morphology. It can transform into a higher degree block and can also manifest transiently. IAB may be a preceding or causative risk factor for various atrial arrhythmias (esp. atrial fibrillation) and also be associated with various other clinical abnormalities ranging from left atrial dilation and thromboembolism including embolic stroke and mesenteric ischemia. IAB certainly deserves more attention and prospective studies are needed to formulate a standard consensus regarding appropriate management strategies. 相似文献
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Raghu Ram EV Kumar A Biswas S Kumar A Chaubey S Siddiqi MI Habib S 《Molecular and biochemical parasitology》2007,154(1):30-39
The DNA replication machinery of the Plasmodium falciparum apicoplast is a validated drug target. Nuclear-encoded gyrase subunits are predicted to play a critical role in maintaining DNA topology during the D-loop/bi-directional ori replication process of the parasite. We show the presence of P. falciparum gyrase subunits in parasite lysates by using antibodies generated against recombinant gyrase A and B. The ATPase activity of PfGyrB was inhibited by novobiocin that also caused parasite death in culture. Reduction of apicoplast/nuclear DNA ratio in the presence of novobiocin indicated that the drug targets apicoplast DNA replication. Molecular modeling of gyrase A and B subunits revealed extensive fold conservation with the Escherichia coli counterparts as well as the presence of a long disordered loop adjacent to the ATPase domain of PfGyrB. Our results have implications for development of PfGyrB as a drug target against malaria. 相似文献
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Sudha Sazawal Rekha Chaubey Pawandeep Kaur Sunita Chikkara Bijender Kumar Sameer Bakshi L. S. Arya Vinod Raina Alakananda Das Gupta Renu Saxena 《Indian journal of hematology & blood transfusion》2014,30(4):219-225
Genetic polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) gene have been associated with the development of acute leukemias and various malignancies. The role of MTHFR polymorphism in the development of pediatric acute lymphoblastic leukemia (ALL) has been extensively studied among north Indians in various settings, yet its association with acute leukemias remains unresolved. To evaluate the relationship between functional MTHFR polymorphisms, C677T and A1298C and possible effect on risk of ALL in adults and children in North Indian population by comparing them with healthy controls. DNA was isolated from peripheral blood of 184 ALL patients (33 adults, 151 children) and 155 controls and analyzed by a PCR-restriction fragment length polymorphism assay. The frequency of MTHFR 677CT and 1298 AC genotypes were significantly lower among adult ALL cases when compared to the controls. We found a 1.74-fold reduced risk of ALL in individuals with 1298AC polymorphic variant and a 9.17-fold decreased risk of adult ALL. However, no statistically significant difference was evident between the above polymorphisms and susceptibility to ALL in children. Polymorphisms in the MTHFR gene possibly modulate risk of ALL in north Indian adults but not in children, although larger studies are needed. 相似文献
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Sreekumar R. Thekkatavan Ajeesh Shrivastava Pankaj Kumawat R. K. Dixit Shivani Chaubey Gyaneshwer 《International journal of legal medicine》2020,134(5):1679-1681
International Journal of Legal Medicine - In this study, we assessed and established an allelic frequency database of Malayalam-speaking population of south western Indian state Kerala, using 15... 相似文献
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Kumar Anand Kumar Rajesh Kumawat R. K. Mathur Baiju Shrivastava Pankaj Chaubey Gyaneshwer Yadav Rajesh Kumar 《International journal of legal medicine》2020,134(5):1691-1693
International Journal of Legal Medicine - This study was conducted to come up with data on Y-STR markers for the population of Rajasthan comprising of the western arid region of India. Y-STR... 相似文献
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Floating thrombus in the aorta 总被引:2,自引:0,他引:2
A review of the literature shows that there are few reported cases of embolism or thrombus in a nonaneurysmal, effectively normal aorta with no other underlying reason for thrombus formation in the aorta. We report a case of a large, floating thrombus in the descending aorta lumen and discuss surgical and management options. 相似文献
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A peptide nucleic acid-neamine conjugate that targets and cleaves HIV-1 TAR RNA inhibits viral replication 总被引:1,自引:0,他引:1
Riguet E Tripathi S Chaubey B Désiré J Pandey VN Décout JL 《Journal of medicinal chemistry》2004,47(20):4806-4809
The neamine part of the aminoglycoside antibiotic neomycin B was conjugated to a 16 mer peptide nucleic acid (PNA) targeting HIV-1 TAR RNA. Attachment of the neamine core allows cellular uptake of the PNA and results in potent inhibition of HIV-1 replication. The polycationic neamine moiety imparts greater solubility to the PNA and also confers a unique RNA cleavage property to the conjugate which is specific to its target site and functional at physiological concentrations of Mg(2+). These properties suggest a potential therapeutic application for this class of compounds. 相似文献