全文获取类型
收费全文 | 339篇 |
免费 | 8篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 16篇 |
妇产科学 | 5篇 |
基础医学 | 27篇 |
口腔科学 | 2篇 |
临床医学 | 37篇 |
内科学 | 39篇 |
皮肤病学 | 3篇 |
神经病学 | 2篇 |
特种医学 | 124篇 |
外科学 | 25篇 |
综合类 | 17篇 |
预防医学 | 14篇 |
药学 | 19篇 |
肿瘤学 | 19篇 |
出版年
2022年 | 2篇 |
2021年 | 3篇 |
2020年 | 2篇 |
2018年 | 2篇 |
2017年 | 3篇 |
2016年 | 2篇 |
2015年 | 6篇 |
2014年 | 4篇 |
2013年 | 9篇 |
2012年 | 2篇 |
2011年 | 5篇 |
2010年 | 6篇 |
2009年 | 13篇 |
2008年 | 10篇 |
2007年 | 16篇 |
2006年 | 20篇 |
2005年 | 22篇 |
2004年 | 17篇 |
2003年 | 20篇 |
2002年 | 18篇 |
2001年 | 18篇 |
2000年 | 19篇 |
1999年 | 11篇 |
1998年 | 24篇 |
1997年 | 21篇 |
1996年 | 12篇 |
1995年 | 8篇 |
1994年 | 14篇 |
1993年 | 4篇 |
1992年 | 5篇 |
1991年 | 1篇 |
1990年 | 6篇 |
1989年 | 1篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有350条查询结果,搜索用时 15 毫秒
1.
Magnetic Resonance Enteroclysis 总被引:5,自引:0,他引:5
Nicholas C. Gourtsoyiannis Nickolas Papanikolaou 《Seminars in Ultrasound, CT and MRI》2005,26(4):237-246
MR enteroclysis (MRE) is an emerging technique for the evaluation of small intestinal diseases. Administration of an iso-osmotic water solution through a nasojejunal catheter can guarantee adequate luminal distention, and in combination with ultrafast sequences, such as single shot TSE, true FISP, HASTE and 3D FLASH, results in excellent anatomic demonstration of the small intestine. MR fluoroscopy can be performed during MRE examination to monitor the filling process and might be useful in studying low-grade stenosis or motility related disorders. MRE is a very promising technique for the detection and characterization of involved small bowel segments in patients with Crohn's disease while its diagnostic performance in disclosing lumen narrowing and extramural manifestations and complications of the disease is outstanding. Initial experience shows that MRE is very efficient in the diagnosis of small bowel tumors and can be used in the evaluation of small bowel obstruction. 相似文献
2.
Arbour NC; Zlotogora J; Knowlton RG; Merin S; Rosenmann A; Kanis AB; Rokhlina T; Stone EM; Sheffield VC 《Human molecular genetics》1997,6(5):689-694
Achromatopsia is an autosomal recessive disease of the retina,
characterized clinically by an inability to distinguish colors, impaired
visual acuity, nystagmus and photophobia. A genome-wide search for linkage
was performed using an inbred Jewish kindred from Iran. To facilitate the
genome-wide search, we utilized a DNA pooling strategy which takes
advantage of the likelihood that the disease in this inbred kindred is
inherited by all affected individuals from a common founder. Equal molar
amounts of DNA from all affected individuals were pooled and used as the
PCR template for short tandem repeat polymorphic markers (STRPs). Pooled
DNA from unaffected members of the kindred was used as a control. A
reduction in the number of alleles in the affected versus control pool was
observed at several loci. Upon genotyping of individual family members,
significant linkage was established between the disease phenotype and
markers localized on chromosome 2. The highest LOD score observed was 5.4
(theta = 0). When four additional small unrelated families were genotyped,
the combined peak LOD score was 8.2. Analysis of recombinant chromosomes
revealed that the disease gene lies within a 30 cM interval which spans the
centromere. Additional fine-mapping studies identified a region of
homozygosity in all affected individuals, narrowing the region to 14 cM. A
candidate gene for achromatopsia was excluded from this disease interval by
radiation hybrid mapping. Linkage of achromatopsia to chromosome 2 is an
essential first step in the identification of the disease-causing gene.
相似文献
3.
Varveris C Koukourakis M Pissakas G Maris T Karpassitis N Katsenis A Kiparissiadis P Gourtsoyiannis N 《Oncology reports》1994,1(2):445-451
Our analysis presents a group of 86 patients with unresectable colorectal cancer who were treated with radical or palliative external beam radiotherapy from 1979-1990 at the Radiation Oncology Department of Greek Anticancer Institute, St. Savvas Hospital, Athens. The dose applied to the tumor area was 20-50 Gy in 2-6 weeks. A CAT-scan guided boost field portal to the primary tumor bed and immediately adjacent nodes was also used. Irradiation was given with a Co-60 unit or a 6 MeV Linear Accelerator using a two, three or 4-field technique. Complete symptomatic relief was achieved in 90% of patients with rectal bleeding, 63% with pain and 37% with mucous discharge. Although the majority of our patients received a higher than 40Gy radiation dose, we have seen symptomatic relief in up to 90% of patients treated with 20-30 Gy in 2-3 weeks. However, the duration of improvement in symptomatic relief of our patients was better for those who had been given higher doses of radiation therapy. The radiation dose was sufficient to relieve symptoms in 40 patients (46.5%) for more than 12 months and in 20 patients (23.2%) for 8-12 months. 相似文献
4.
5.
Panos K. Prassopoulos Christina A. Giannakopoulou Eleni G. Apostolaki Nickolas Z. Charoulakis Nickolas C. Gourtsoyiannis 《Pediatric radiology》1998,28(8):605-607
Psoas abscess in children, and especially in neonates, is an uncommon condition which is difficult to diagnose clinically.
The US, CT and MR findings of a psoas abscess in a neonate, which extended to the thigh, are reported. Imaging was helpful
in revealing the abnormality, in demonstrating its extension and in determining its nature. The child was treated conservatively
and the abscess resolved, leaving atrophy of the psoas muscle.
Received: 24 June 1997 Accepted: 9 January 1998 相似文献
6.
7.
Raissaki M Hatzidakis AA Prassopoulos P Bakandaki A Vrachassotakis N Vasilakis SJ Gourtsoyiannis NC 《European radiology》2000,10(8):1284-1286
A case of recurrent abdominal wall abscess following percutaneous cholecystostomy (PC) is presented. Transperitoneal PC was
performed in an 82-year-old female with calculous cholecystitis. Symptoms resolved and the catheter was removed 29 days later.
The patient came back 5 months later with a superficial abscess that was drained and 8 months post PC with a fistula discharging
clear fluid. Ultrasonography revealed the tract adjacent to an area of inflammation containing a calculus, whereas CT failed
to depict the stone. Subsequent surgery confirmed US findings. To our knowledge, this is the first report of a dislodged bile
stone following percutaneous cholecystostomy.
Received: 27 August 1999; Revised: 7 December 1999; Accepted: 9 December 1999 相似文献
8.
9.
In vivo expression of the B7 costimulatory molecule by subsets of antigen-presenting cells and the malignant cells of Hodgkin's disease 总被引:10,自引:0,他引:10
Munro JM; Freedman AS; Aster JC; Gribben JG; Lee NC; Rhynhart KK; Banchereau J; Nadler LM 《Blood》1994,83(3):793-798
The B-lymphocyte/accessory-cell activation antigen B7 (BB1) has been shown in vitro to stimulate T-lymphocyte proliferation and cytokine production via CD28 present on the latter cells. In this study, benign lymphoid tissues, lymphomas, and extralymphoid inflammatory sites were examined immunohistochemically using anti-B7 and other relevant monoclonal antibodies. B7 was expressed by benign transformed germinal center B cells, as it was by B cells of follicular lymphomas. B7 was also expressed by a subpopulation (a mean of 31% to 65%) of macrophages and dendritic cells in a variety of lymphoid tissues. It was present in abundance on all macrophages constituting sarcoid granulomas in lymph nodes. In extralymphoid inflammation, 17% to 35% of macrophages expressed B7 only weakly. Cases of Hodgkin's disease showed expression of B7 by the majority of Reed-Sternberg cells or malignant mononuclear variants, a phenomenon that potentially contributes to the lymphocytic accumulation that is a feature of this condition. CD28+ T cells were seen in all areas where T cells were present. B7+ and CD28+ cells colocalized in, for example, lymphoid follicles, lymph node paracortex, sarcoid granulomas, and Hodgkin's disease tissue, indicating a potential for cellular interaction via these molecules at these sites. 相似文献
10.
Tsetis DK Katsamouris AN Androulakakis Z Chamalakis K Kostas T Chlapoutakis K Gourtsoyiannis NC 《Cardiovascular and interventional radiology》2003,26(6):572-575
The Trellis Peripheral Infusion System is an over-the-wire 0.035 guidewire compatible device, designed to isolate a region of the peripheral vasculature to allow for lytic drug infusion and dispersion. We used it successfully through a percutaneous approach in two cases of acute thrombosis of a native lower limb artery. The total amount of rt-PA used was 12 and 9 mg, respectively and was delivered through bolus injections obviating the need for a supplementary continuous infusion of the agent. The time for dissolution of thrombus was 45 and 35 minutes, respectively. No complications were observed. 相似文献