全文获取类型
收费全文 | 189508篇 |
免费 | 1957篇 |
国内免费 | 129篇 |
专业分类
耳鼻咽喉 | 1255篇 |
儿科学 | 7058篇 |
妇产科学 | 3427篇 |
基础医学 | 18735篇 |
口腔科学 | 1802篇 |
临床医学 | 13520篇 |
内科学 | 34120篇 |
皮肤病学 | 1029篇 |
神经病学 | 18438篇 |
特种医学 | 9268篇 |
外科学 | 30021篇 |
综合类 | 2336篇 |
一般理论 | 1篇 |
预防医学 | 18878篇 |
眼科学 | 2891篇 |
药学 | 10455篇 |
中国医学 | 655篇 |
肿瘤学 | 17705篇 |
出版年
2024年 | 30篇 |
2023年 | 204篇 |
2022年 | 439篇 |
2021年 | 736篇 |
2020年 | 402篇 |
2019年 | 504篇 |
2018年 | 22421篇 |
2017年 | 17728篇 |
2016年 | 19950篇 |
2015年 | 1473篇 |
2014年 | 1494篇 |
2013年 | 1681篇 |
2012年 | 8227篇 |
2011年 | 22224篇 |
2010年 | 19469篇 |
2009年 | 12131篇 |
2008年 | 20515篇 |
2007年 | 22603篇 |
2006年 | 1407篇 |
2005年 | 2927篇 |
2004年 | 4063篇 |
2003年 | 4941篇 |
2002年 | 2937篇 |
2001年 | 306篇 |
2000年 | 433篇 |
1999年 | 207篇 |
1998年 | 295篇 |
1997年 | 260篇 |
1996年 | 128篇 |
1995年 | 135篇 |
1994年 | 136篇 |
1993年 | 76篇 |
1992年 | 53篇 |
1991年 | 98篇 |
1990年 | 136篇 |
1989年 | 87篇 |
1988年 | 56篇 |
1987年 | 47篇 |
1986年 | 31篇 |
1985年 | 36篇 |
1984年 | 23篇 |
1983年 | 25篇 |
1982年 | 30篇 |
1980年 | 46篇 |
1938年 | 60篇 |
1937年 | 25篇 |
1935年 | 22篇 |
1934年 | 30篇 |
1932年 | 56篇 |
1930年 | 46篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Marco Maruzzo Umberto Basso Eugenio Borsatti Laura Evangelista Filippo Alongi Orazio Caffo Francesca Maines Sara Galuppo Rocco De Vivo Fable Zustovich Dario Palleschi Andrea Zivi Teodoro Sava Mariella Sorarù Roberto Iacovelli Maurizio Nicodemo Susanne Baier Lucia Fratino Vittorina Zagonel 《Clinical genitourinary cancer》2019,17(1):e187-e194
Background
Radium 223 was introduced for metastatic castration-resistant prostate cancer based on the results of a randomized controlled trial showing risk reduction for death and skeletal events. Our aim was to evaluate the outcome of patients receiving radium 223 in a real-world setting.Patients and Methods
We conducted a multicenter retrospective analysis in the Triveneto region of Italy.Results
One hundred fifty-eight patients received radium 223 in our region. After a median follow-up of 9.5 months, 75 patients died. The median overall survival (OS) was 14.2 months, and the median progression-free survival (PFS) was 6.2 months. Seventy-one (45%) patients achieved progression as best response. Thirty-seven (23%) patients stopped the treatment early because of progression. Eastern Cooperative Oncology Group performance status was prognostic for OS (18.4 vs. 12.3 vs. 7.5 months; 0 vs. 1, P = .0062; 0 vs. 2, P = .0002), whereas previous prostatectomy or docetaxel exposure were not. A neutrophil to lymphocytes ratio ≥ 3 significantly impacted OS (18.1 vs. 9.7 months; P < .001) and slightly impacted PFS (6.6 vs. 5.6 months; P = .05). Patients with a baseline alkaline phosphatase (ALP) value ≥ 220 U/L had worse OS and PFS (24.1 vs. 10.5 months; 7.2 vs. 5.5 months; P < .001). Patients with changes in ALP value achieved better OS (P = .029) and PFS (P = .002). There was no difference according to the line of therapy (0 vs. ≥ 1; P = .490). The main grade 3/4 toxicities were anemia, asthenia, and thrombocytopenia.Conclusion
This large real-world report confirms comparable OS and PFS data when compared with the pivotal study, as well as the predictive role of ALP and neutrophil to lymphocytes ratio. The definition of the optimal position of radium 223 in the treatment of metastatic castration-resistant prostate cancer has still to be defined. 相似文献3.
4.
5.
6.
7.
Susanne Ramsauer 《Zeitschrift für Psychodrama und Soziometrie》2007,6(2):293-302
Anliegen dieses Artikels ist, die besondere Qualit?t und Chance von Psychodramatischer Supervision zu beschreiben, und gleichzeitig
die Kompatibilit?t und fruchtbare Erg?nzung des Moreno’schen Ansatzes innerhalb des Formats Supervision innerhalb der Sozialen
Arbeit auf zuzeigen. Dies wird anhand von 2 ausgew?hlten Praxisbeispielen dargestellt. Die Handlungskompetenz von Supervisandinnen
und Supervisanden kann durch einfache psychodramatische Interventionen erweitert werden. Handlungshemmung wird überwunden,
Spontaneit?t und Kreativit?t kommen ins Laufen und er?ffnen Perspektiven. 相似文献
8.
9.
Debra L. Roter Richard M. Frankel Judith A. Hall David Sluyter 《Journal of general internal medicine》2006,21(1):28-34
Relationship-centered care reflects both knowing and feeling: the knowledge that physician and patient bring from their respective domains of expertise, and the physician’s and patient’s experience, expression, and perception of emotions during the medical encounter. These processes are conveyed and reciprocated in the care process through verbal and nonverbal communication. We suggest that the emotional context of care is especially related to nonverbal communication and that emotion-related communication skills, including sending and receiving nonverbal messages and emotional self-awareness, are critical elements of high-quality care. Although nonverbal behavior has received far less study than other care processes, the current review argues that it holds significance for the therapeutic relationship and influences important outcomes including satisfaction, adherence, and clinical outcomes of care. 相似文献
10.
杨娅 Thomas Bartel Loredana Latina Guido Caspari 王新房 Raimund Erbel 《华中科技大学学报(医学英德文版)》2002,22(2):158-163
Coronary flow reserve (CFR) has been used toassess coronary microcirculation and epicardial coro-nary stenoses[1— 3 ] . CFR is defined as the ratio ofcoronary flow under maximal coronary vasodilatationto coronary flow under resting conditions[4 ] .Whenthe cross- sectional area of epicardial coronary arteriesis constant,coronary flow velocity (CFV) ratios areequal to volume flow ratios.The most common method used clinically formeasuring CFVR is intracoronary Doppler flow(ICD) analysis re… 相似文献