Safety profile of the adjuvanted recombinant zoster vaccine: Pooled analysis of two large randomised phase 3 trials

Background

The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes zoster in adults. Here we present a comprehensive overview of the safety data from these studies.

New bromopyrrole alkaloids from the Indopacific sponge Agelas nakamurai.

Two new dimeric bromopyrrole alkaloids, nakamuric acid (1) and its corresponding methyl ester (2), have been isolated from the Indopacific sponge Agelas nakamurai along with the known metabolites sceptrin (3), debromosceptrin (4), and ageliferin (5). Their structures were identified by analysis of spectral data. All compounds inhibited the growth of several Gram-positive and Gram-negative bacteria in the agar plate diffusion assay.     

Effect of maternal protein deprivation on the development of neonatal intestinal function in rats.

The developmental pattern of in vitro intracellular accumulation (IA) was studied in the small intestine of the offspring of females fed a 27% protein diet (normal) (NPD animals) and the offspring of females fed an 8% protein diet (low) (LPD animals). At 2 days of age, the IA of L-leucine (Leu) and D-galactose (Gal) was significantly reduced in the intestines of the LPD animals as compared to the NPD animals at initial velocities (75% and 81%) and under steady state conditions (82% and 84%). The IA of both compounds in the intestines of the LPD animals increased relative to the NPD animals until at weaning the IA of Leu and Gal under steady state conditions was significantly greater in the LPD animals (139% and 133%). After weaning, the IA of Leu was statistically increased (137%) and the IA of Gal was the same in the LPD animals as compared to the NPD animals at initial velocities. The variations in the developmental patterns of the IA of Leu and Gal in the intestines of LPD animals as compared to NPD animals appear to be related to animal age, which may reflect an improved caloric intake at weaning.     

Prognostic biomarkers in men with metastatic castration-resistant prostate cancer receiving [177Lu]-PSMA-617

European Journal of Nuclear Medicine and Molecular Imaging - We analysed quantitative biomarkers derived from both baseline whole-body imaging and blood serum to identify prognostic markers in...     

Das Hodgkin-Lymphom in fortgeschrittenen Stadien

Die Onkologie - Sowohl gemäß der Positronenemissionstomographie (PET-)adaptierte Protokolle als auch neue Substanzen haben in den letzten Jahren Einzug in die Erstlinientherapie des...     

Older patients request more information: a survey of use of written patient education materials in general practice

Objectives: To determine GPs' reported use of written education materials with older patients and older patients' reported receipt of these materials. To determine GPs' and older patients' perceptions of written materials. Method: Using self‐report questionnaires, two populations were surveyed; a randomised sample of SO GPs (29 males and 21 females) practising in Brisbane's southern suburbs and a convenience sample of 188 older community‐dwelling people (aged over 64 years). Results: All GPs reported using written materials with patients, although 28% had not given any to the last 10 patients. This increased to 46% when patients were older. Twenty percent of patients wanted more written information from their GP, while some GPs believed that older patients preferred verbal information and gave out written information only when they perceived patient interest. All GPs reported giving written materials at the time of consultation and over two‐thirds discussed the content with patients. Just over 50% of patients reported receiving written information from GPs in the last six months and only half of these again discussed it directly with their GP. Overall, patients were more positive than GPs about the value of written education materials. Conclusions: Older patients' desire for written information may be better met if they are more assertive in requesting this of GPs and GPs may better serve their patients' needs if they make written information more readily available to them. Better access to materials and more financial incentives to give them out might also increase GPs' use of written materials.