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Alcohol and sleep apnea 总被引:1,自引:0,他引:1
Acute ingestion of ethanol induces vasodilation and swelling of respiratory mucosa; it depresses respiratory centers resulting in hypotonia of oropharyngeal dilator muscles and inducing or aggravating sleep apnea. However, no association between the sleep apnea syndrome (SAS) and Alcohol Use Disorders (AUD) has been demonstrated. 相似文献
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Kushare Indranil Ghanta Ramesh B. Ditzler Matthew Jadhav Siddharth P. 《Emergency radiology》2021,28(4):723-727
Emergency Radiology - To describe the first “arcuate sign” case series in the pediatric population, radiologic features of the associated injuries, management, and how they compare with... 相似文献
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Although inhalant abuse represents the third most commonly abused class of drugs in the military, it is a frequently overlooked form of substance abuse in the active duty population. Inhalants' lack of visibility is also evident in the civilian community. In both the civilian and military communities, the factors leading to underrecognition of inhalant abuse include high availability, low cost, lack of drug screening and drug treatment programs, and frequent misdiagnosis by clinicians. This review seeks to inform care providers about the prevalence, health risks, diagnosis, and treatment of inhalant abuse in the active duty population, and encourages clinicians to be more aggressive in the identification of this serious but underrecognized problem. 相似文献
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Abstract. Curson's analysis of the growth of private for profit treatment of substance abuse is seen as exaggerated. The main growth in the 1980s was over 50% in the voluntary charitable sector. His criticism of lay' counsellors ignores the responsibility of health care professionals, to train and supervise them. Curson's criticism of the effectiveness of treatment in general indicates he is not well informed and his reference to Minnesota Model outcome research and the philosophy of the mutual help movement of AA is misleading. 相似文献
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Efficacy and tolerability of memantine in patients with dementia syndrome. A double-blind, placebo controlled trial. 总被引:6,自引:0,他引:6
K Ditzler 《Arzneimittel-Forschung》1991,41(8):773-780
The efficacy and tolerability of memantine (1-amino-3,5-dimethyl-adamantane hydrochloride, Akatinol Memantine; CAS 41100-52-1) was investigated in a double-blind, randomized clinical study versus placebo in 66 patients aged between 65 and 80 years predominantly suffering from mild to moderate vascular dementia. The target variables assessed were the baseline differences of the Sandoz Clinical Assessment Geriatric scale (SCAG) and Syndrom-Kurz-Test (SKT) total scores and the total time required in the subtests of Activity of Daily Living tests (ADL). Additional parameters assessed were the physician's global impression, the Mini Mental State Evaluation (MMSE), the Tapping and Trace tests for fine motor rating and the quality in performing the ADL tests. Adverse drug effects were recorded by DOTES/TWIS. 59 of the 66 patients included in the study terminated the trial (29 in the placebo and 30 in the memantine group). For the baseline differences of the SCAG total score a statistically significant improvement was observed already after 14 days of memantine treatment as compared to placebo. After 42 days this difference was still more pronounced and highly significant. Significant improvements after 14 and 42 days of memantine treatment could also be demonstrated for the SCAG subscales cognitive disturbances, lack of drive, emotional disturbances, social behaviour and somatic disturbances. Additionally, the efficacy of the drug could be confirmed by the SKT and ADL tests. Particularly striking in the ADL tests was the considerable improvement achieved in the quality of performing the tasks under memantine treatment.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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Emily Girard Sally Ditzler Donghoon Lee Andrew Richards Kevin Yagle Joshua Park Hedieh Eslamy Dmitri Bobilev Patricia Vrignaud James Olson 《Neuro-oncology》2015,17(1):107-115