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Anne Kaltoft MD PhD Søren Steen Nielsen MD Christian Juhl Terkelsen MD PhD Morten Bøttcher MD PhD Jens Flensted Lassen MD PhD Lars Romer Krusell MD Steen Dalby Kristensen MD DMSCi Jan Ravkilde MD DMSCi Henning Kelbæk MD DMSCi Hans Erik Bøtker MD DMSCi Evald Høj Christiansen MD PhD Michael Rehling MD DMSCi Leif Thuesen MD DMSCi 《Journal of nuclear cardiology》2009,16(5):784-791
Aim
Distal embolization during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) may result in reduced myocardial perfusion, infarct extension and impaired prognosis. In a prospective randomized trial, we assessed the effect of routine filterwire distal protection on scintigraphic estimated infarct size.Methods and results
The effect of routine filterwire distal protection was evaluated in 344 patients with STEMI <12 hours undergoing primary PCI. Patients were randomized to distal protection with a filterwire or standard PCI. The primary endpoint was myocardial infarct size measured by Sestamibi SPECT after 30 days (%). Secondary endpoints included myocardial salvage, ST-segment resolution (STR), myocardial biomarker release and major adverse cardiac and cerebral events. Baseline characteristics including area at risk (estimated by Sestamibi SPECT) were similar. Final infarct size was not statistically different in the distal protection and the control groups (median [IQR], 6% [1-19] and 5% [1-14], P = .23). Also, secondary endpoints were similar in the two treatment groups.Conclusion
Distal protection with a filterwire performed as routine therapy in primary PCI for STEMI did not reduce myocardial infarct size. The study does not support routine use of distal protection in primary PCI. 相似文献2.
Heiko Pohl MD Thien Phu Do MD David García-Azorín MD MSci Jakob Møller Hansen MD PhD MSc Espen Saxhaug Kristoffersen MD PhD Sarah E. Nelson MD Mark Obermann MD PhD Peter S. Sandor MD Christoph J. Schankin MD Henrik Winther Schytz MD PhD DMSCi Alexandra Sinclair MBChB FRCP PhD Guus G. Schoonman MD PhD Andreas R. Gantenbein MD 《Headache》2021,61(2):300-309
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