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Simone Maurea Alberto Cuocolo Leonardo Pace Emanuele Nicolai Antonio Nappi Massimo Imbriaco Carmine Morisco Massimo Chiariello Bruno Trimarco Marco Salvatore 《European journal of nuclear medicine and molecular imaging》1993,20(6):502-510
To compare rest-injected thallium-201 (Tl) redistribution and resting technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) myocardial uptake in chronic coronary artery disease (CAD), 15 patients with angiographically proven CAD and left ventricular (LV) dysfunction (ejection fraction 34%±9%) were studied. All patients underwent rest-redistribution Tl and resting 99mTc-MIBI cardiac imaging. Gated 99mTc-MIBI images were also acquired to assess regional LV wall motion (WM). Myocardial segments (n=225) were divided into three groups on the basis of the degree of coronary artery stenosis: group 1 (total occlusion, n=82), group 2 (50%–99% of stenosis, n=84) and group 3 (<50% of stenosis, n=59). WM was significantly worse in groups 1 and 2 compared to group 3 (P<0.001), but no difference was observed between groups 1 and 2. TI and 99mTc-MIBI uptake were significantly lower in groups 1 and 2 compared to group 3 (P < 0.001), and in group 1 compared to group 2 (P<0.001). When TI and 99mTc-MIBI uptake were directly compared, TI uptake was higher than 99mTc-MIBI uptake in group 1 (P<0.001), while no significant difference was observed in groups 2 and 3. Thus, both rest-injected TI redistribution and resting 99mTc-MIBI uptake reflected the severity of coronary artery stenosis in CAD. However, in myocardial segments with total coronary occlusion T1 uptake was significantly higher than 99mTc-MIBI uptake. Our data suggest that rest-injected Tl redistribution cardiac imaging may identify, more accurately than resting 99mTc-MIBI imaging, the presence of viable myocardium in chronic CAD, particularly when the coronary blood flow is severely impaired. 相似文献
3.
Emanuele Nicolai Alberto Cuocolo Leonardo Pace Antonio Nappi Pasquale Sullo Stefania Cardei Luigi Argenziano Fiorenzo Squame Peter J. Ell Marco Salvatore 《Journal of nuclear cardiology》1996,3(1):9-17
Background
Exercise and dipyridamole 99mTc-labeled methoxy isobutyl isonitrile (MIBI) myocardial scintigraphy have been widely used for the diagnosis of coronary artery disease (CAD). However, only limited data on adenosine 99mTc-labeled MIBI cardiac imaging are currently available. This study was designed to assess the accuracy of quantitative adenosinerest 99mTc-labeled MIBI tomography in the diagnosis and localization of CAD.Methods and Results
Fifty-seven consecutive patients with suspected CAD who underwent coronary angiography and 22 normal volunteers were studied. All patients underwent 99mTc-labeled MIBI tomography after administration of adenosine (140 μg/kg intravenously for 6 minutes) and at rest. A total of 171 vascular coronary territories were analyzed quantitatively. All patients with CAD (≥50% luminal stenosis) (n=55) had abnormal 99mTc-labeled MIBI tomograms. The normalcy rate was 86% by quantitative analysis. Overall sensitivity, specificity, and diagnostic accuracy for detection of individual stenosed vessels were 84%, 87%, and 85%, respectively. In patients with one-vessel CAD (n=24), sensitivity and diagnostic accuracy in the detection of individual stenosed vessels were significantly (p<0.05) higher compared with patients with multivessel CAD (n=31). Moreover, 75% of patients with one-vessel disease showed a scintigraphic pattern characterized by the presence of perfusion defects in only one coronary artery territory, and 74% of patients with multivessel disease showed a scintigraphic pattern characterized by the presence of perfusion defects in two or more coronary artery territories. Sensitivity, specificity, and diagnostic accuracy for detecting individual diseased vessels were similar in patients without previous myocardial infarction (n=18) compared with those with previous myocardial infarction (n=39). In myocardial territories related to noninfarcted areas (n=124), sensitivity and specificity in the detection of stenosed vessels were 75% and 88%. In infarcted areas (n=47), sensitivity and specificity in the detection of stenosed vessels were 98% and 80% (differences not significant vs noninfarcted areas).Conclusions
Adenosine-controlled coronary vasodilation combined with quantitative 99mTc-labeled MIBI tomography is accurate for identifying patients with CAD and localizing individual stenosed coronary arteries. 相似文献4.
Pasquale Sullo Alberto Cuocolo Emanuele Nicolai Stefania Cardei Antonio Nappi Fiorenzo Squame Eugenio M. Covelli Leonardo Pace Marco Salvatore 《European journal of nuclear medicine and molecular imaging》1996,23(6):648-655
The aim of this study was to evaluate the accuracy of quantitative 1-day exercise-rest technetium-99m tetrofosmin tomography in the identification of patients with coronary artery disease (CAD) and in the detection of individual stenosed coronary vessels. Sixty-one patients with suspected CAD who underwent coronary angiography and 13 normal volunteers were studied. All patients were submitted to two i.v. injections of99mTc-tetrofosmin, one at peak exercise (370 MBq) and the other (1110 MBq) at rest 3 h after exercise (images 15–30 min after injection for both studies). All patients with CAD (0% luminal stenosis) (n=50) had an abnormal99mTc-tetrofosmin tomogram. Only one patient without significant coronary narrowing showed abnormal findings. Overall sensitivity, specificity and diagnostic accuracy in the detection of individual stenosed vessels were 77%, 93% and 85%, respectively. Sensitivity and diagnostic accuracy in the identification of individuals stenosed coronary vessels were significantly higher (P<0.05) in patients with single-vessel disease (n=21) than in those with multivessel disease (n=29). Sensitivity, specificity and accuracy for detecting individual diseased vessels were similar in patients without previous myocardial infarction (n=26) and in those with previous myocardial infarction (n=35). In myocardial territories related to non-infarcted areas (n=128), sensitivity and specificity in the detection of stenosed vessels were 70% and 95%, respectively. In infarcted areas (n=55), sensitivity and specificity in the detection of stenosed vessels were 85% (P=NS vs non-infarcted areas) and 75% (P<0.05 vs non-infarcted areas), respectively. Finally, sensitivity was significantly lower (P<0.05) in vascular territories supplied by vessels with moderate stenosis (50%–75%) than in those supplied by vessels with severe stenosis (>75%). The results of this study demonstrate that quantitative 1-day exercise-rest99mTc-tetrofosmin single-photon emission tomographic imaging is a suitable and accurate technique to identify patients with CAD and to detect individual stenosed coronary vessels. 相似文献
5.
Hein J. Verberne Wanda Acampa Constantinos Anagnostopoulos Jim Ballinger Frank Bengel Pieter De Bondt Ronny R. Buechel Alberto Cuocolo Berthe L. F. van Eck-Smit Albert Flotats Marcus Hacker Cecilia Hindorf Philip A. Kaufmann Oliver Lindner Michael Ljungberg Markus Lonsdale Alain Manrique David Minarik Arthur J. H. A. Scholte Riemer H. J. A. Slart Elin Trägårdh Tim C. de Wit Birger Hesse 《European journal of nuclear medicine and molecular imaging》2015,42(12):1929-1940
6.
Dario Leosco Valentina Parisi Teresa Pellegrino Gennaro Pagano Grazia Daniela Femminella Agnese Bevilacqua Stefania Paolillo Roberto Formisano Gaetana Ferro Claudio de Lucia Maria Prastaro Pasquale Perrone Filardi Alberto Cuocolo Giuseppe Rengo Nicola Ferrara 《European journal of nuclear medicine and molecular imaging》2015,42(10):1601-1611
7.
Stable improvement in large artery compliance after long-term antihypertensive treatment with enalapril 总被引:1,自引:0,他引:1
N De Luca B Ricciardelli G Rosiello G Lembo M Volpe A Cuocolo B Trimarco 《American journal of hypertension》1988,1(2):181-183
In 12 patients with mild or moderate essential hypertension we assessed by 2-D pulsed Doppler flowmetry the influence of a 6-month effective treatment with enalapril or atenolol on peripheral hemodynamics. The patients were studied in control conditions, at the end of the 6-month pharmacologic treatment, and 2 weeks after the withdrawal of the therapy. In spite of a comparable fall in blood pressure, the effects of the two drugs on forearm hemodynamics were quite different. Enalapril induced a fall in vascular resistance and an increase in brachial artery diameter, flow, and compliance, while atenolol failed to modify all these parameters. In the enalapril group the improvement in forearm vascular resistance and brachial artery compliance persisted after the 2-week washout period. This latter observation raises the possibility that enalapril may reverse structural changes in the large arteries. 相似文献
8.
Giuseppe Rengo Gennaro Pagano Dino Franco Vitale Roberto Formisano Klara Komici Laura Petraglia Valentina Parisi Grazia Daniela Femminella Claudio de Lucia Stefania Paolillo Alessandro Cannavo Emilio Attena Teresa Pellegrino Santo Dellegrottaglie Alessia Memmi Bruno Trimarco Alberto Cuocolo Pasquale Perrone Filardi Dario Leosco Nicola Ferrara 《European journal of nuclear medicine and molecular imaging》2016,43(13):2392-2400
Purpose
Sympathetic nervous system (SNS) hyperactivity is a salient characteristic of chronic heart failure (HF) and contributes to the progression of the disease. Iodine-123 meta-iodobenzylguanidine (123I-mIBG) imaging has been successfully used to assess cardiac SNS activity in HF patients and to predict prognosis. Importantly, SNS hyperactivity characterizes also physiological ageing, and there is conflicting evidence on cardiac 123I-mIBG uptake in healthy elderly subjects compared to adults. However, little data are available on the impact of ageing on cardiac sympathetic nerve activity assessed by 123I-mIBG scintigraphy, in patients with HF.Methods and results
We studied 180 HF patients (age?=?66.1?±?10.5 years [yrs]), left ventricular ejection fraction (LVEF?=?30.6?±?6.3 %) undergoing cardiac 123I-mIBG imaging. Early and late heart to mediastinum (H/M) ratios and washout rate were calculated in all patients. Demographic, clinical, and echocardiographic data were also collected. Our study population consisted of 53 patients aged >75 years (age?=?77.7?±?4.0 year), 67 patients aged 62–72 years (age?=?67.9?±?3.2 years) and 60 patients aged ≤61 year (age?=?53.9?±?5.6 years). In elderly patients, both early and late H/M ratios were significantly lower compared to younger patients (p?<?0.05). By multivariate analysis, H/M ratios (both early and late) and washout rate were significantly correlated with LVEF and age.Conclusions
Our data indicate that, in a population of HF patients, there is an independent age-related effect on cardiac SNS innervation assessed by 123I-mIBG imaging. This finding suggests that cardiac 123I-mIBG uptake in patients with HF might be affected by patient age.9.
Zampella Emilia Acampa Wanda Assante Roberta Gaudieri Valeria Nappi Carmela Mannarino Teresa Mainolfi Ciro Gabriele Arumugam Parthiban Petretta Mario Cuocolo Alberto 《European journal of nuclear medicine and molecular imaging》2020,47(7):1698-1704
European Journal of Nuclear Medicine and Molecular Imaging - Cardiac imaging with positron emission tomography/computed tomography (PET/CT) allows measurement of coronary artery calcium (CAC),... 相似文献
10.