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1.
W J McGahren G O Morton M M Siegel D B Borders J C James G A Ellestad 《The Journal of antibiotics》1986,39(11):1541-1550
The behavior of the free acid and ammonium salt of maduramicin towards heat and alcohols is examined. In refluxing lower alcohols the free acid material is decarboxylated. In addition a bisketal decarboxylated compound as well as an A-ring monoketal decarboxylated derivative are formed. Heating the ammonium salt of the ionophores in suspension in water, or dissolved in inert solvents such as heptane or xylene can cause decarboxylation as well as concomitant dehydration of the F-ring. Reaction of dansyl chloride with the free acid of maduramicin can cause dehydration of the B-ring under very mild conditions. 相似文献
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Genital tract trauma is common following vaginal childbirth, and perineal pain is a frequent symptom reported by new mothers. The following techniques and care measures are associated with lower rates of obstetric lacerations and related pain following spontaneous vaginal birth: antenatal perineal massage for nulliparous women, upright or lateral positions for birth, avoidance of Valsalva pushing, delayed pushing with epidural analgesia, avoidance of episiotomy, controlled delivery of the baby's head, use of Dexon (U.S. Surgical; Norwalk, CT) or Vicryl (Ethicon, Inc., Somerville, NJ) suture material, the "Fleming method" for suturing lacerations, and oral or rectal ibuprofen for perineal pain relief after delivery. Further research is warranted to determine the role of prenatal pelvic floor (Kegel) exercises, general exercise, and body mass index in reducing obstetric trauma, and also the role of pelvic floor and general exercise in pelvic floor recovery after childbirth. 相似文献
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Diane K. Wysowski Lynette Swartz B. Vicky Borders‐Hemphill Margie R. Goulding Catherine Dormitzer 《American journal of hematology》2010,85(9):650-654
Controversy exists about the safety of the parenteral iron dextran products, Dexferrum and INFeD, which have been associated with rare, serious anaphylactic‐type reactions. In the United States, their product labels carry boxed warnings of this adverse event; some have called for the withdrawal from marketing of the higher molecular weight Dexferrum. Between 2002 and 2007, sales of Dexferrum, INFeD, and iron gluconate Ferrlecit declined 32.5%, 21%, and 4.8%, respectively, while sales of iron sucrose Venofer increased 160%. Voluntary reports submitted to the Food and Drug Administration show anaphylactic reactions and symptoms for the four parenteral iron products. Because of underreporting, possible differential reporting, absence of iron dextran brand names, and incomplete use (denominator) data, incidence rates and relative risk estimates cannot be calculated. U.S. death certificate data show that for most years from 1979 through 2006, no more than 3 deaths per year were coded to “adverse events in therapeutic use of iron preparations;” brand names were not consistently recorded. Emergency department data show small numbers of visits for treatment of allergic reactions with intravenous iron preparations. The data presented herein show that allergic reactions are possible with all four parenteral iron products, and it is difficult to determine which product has the largest risk based on sales data, voluntarily submitted adverse event reports, death certificates, ED visits, and observational studies performed to date. To help differentiate risk among the parenteral iron products, the brand name of the product always should be provided on medical records, death certificates, and adverse drug reaction reports. Am. J. Hematol., 2010. Published 2010 Wiley‐Liss, Inc. 相似文献
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Tyrone F Borders K Tom Xu Donna Bacchi Lee Cohen Danielle SoRelle-Miner 《BMC public health》2005,5(1):74
Background
Although tobacco use in the United States has declined over the past 20 years, cigarette use among college students remains high. Additional research is thus needed to determine how university tobacco control policies and preventive education programs affect college students' smoking behaviors. 相似文献7.
OBJECTIVE: To investigate the relationship between medical skepticism and overall self-rated health and to identify disparities in health for vulnerable subgroups among the elderly. DESIGN: A cross-sectional telephone survey involving multiple callbacks. Independent variables included three measures of medical skepticism and disparities variables (low income, low education, race/ethnicity, gender, rural residence) along with several control variables (body weight, marital status, employment, insurance coverage, number of medical visits). SETTING: West Texas, a sparsely populated 108-county region. PARTICIPANTS: Five thousand six persons aged 65 and over. MAIN RESULTS: Multiple logistic regression analysis revealed that medical skepticism (believing that one can overcome illnesses without the help of a medical professional) was independently related to better self-rated overall health. Disparities in health were found for income, race/ethnicity, and low education but not for residents of rural or frontier areas (vs. urban residents). CONCLUSIONS: Belief in one's own ability to manage most illnesses may or may not be causally related to better health. However, the association is promising and deserves further investigation. Programs promoting self-care among groups facing health disparities should be considered. 相似文献
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R G Melcher R A Borders L B Coyne 《American Industrial Hygiene Association journal》1986,47(3):152-157
The purpose of this study was to optimize monitoring methods and to investigate new technology for the determination of low levels of acrylonitrile (0.05 to 5 ppm) in workplace atmospheres. In the first phase of the study, a dynamic atmosphere generation system was developed to produce low levels of acrylonitrile in simulated workplace atmospheres. Various potential sorbents were investigated in the second phase, and the candidate methods were compared in a laboratory validation study over a concentration range from 0.05 to 5 ppm acrylonitrile in the presence of potential interferences and under relative humidity conditions from 30% to 95% RH. A collection tube containing 600 mg Pittsburgh coconut base charcoal was found to be the optimum tube for sampling for a full 8-hr shift. No breakthrough was observed over the concentrations and humidities tested. The recovery was 91.3% with a total relative precision of +/- 21% over the test range, and the recovery was not affected by storage for up to five weeks. 相似文献