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排序方式: 共有1292条查询结果,搜索用时 15 毫秒
1.
PJ Commerford 《Cardiovascular journal of Africa》2015,26(4):151-Aug;26(4):151
2.
Hans Bosma Martin PJ van Boxtel Gertrudis IJM Kempen Jacques ThM van Eijk Jelle Jolles 《BMC public health》2007,7(1):179
Background
The aims of this study were to examine the extent to which higher intellectual abilities protect higher socio-economic groups from functional decline and to examine whether the contribution of intellectual abilities is independent of childhood deprivation and low birth weight and other socio-economic and developmental factors in early life. 相似文献3.
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Previous reports in the literature have described correlation of increasing repeat length with severity of the phenotype, in Kennedy syndrome. We describe male siblings with different repeat lengths, with lack of expression of the phenotype in the sibling with the longer repeat length. The phenotype was identical to motor neurone disease. There is variability of expression in Kennedy syndrome and repeat length even in siblings cannot be taken as a conclusive indicator of severity. CAG repeat length cannot be used to predict the natural history of Kennedy disease. The diagnosis of Kennedy syndrome should be considered in male patients presenting with atypical motor neurone disease. 相似文献
7.
PJ Woll PhD MRCP R Pettengell PhD FRACP 《International journal of clinical practice》1997,51(2):111-115
SUMMARY The interferons are natural glycoproteins secreted in response to various stimuli, including viral infection. They have antiviral, antiproliferative and immunomodulatory effects on different target cell populations. Since recombinant human interferons have become available, they have been tested in a wide range of malignancies. They are well established in the treatment of hairy cell leukaemia, chronic myelogenous leukaemia and multiple myeloma. Although they have documented activity against lymphoma, melanoma, renal cell cancer and carcinoid tumours, their role in the treatment of these tumours is less clear. In the common solid tumours, such as lung cancer and colorectal cancer, the use of interferons remains experimental. Here we will summarise their practice applications in oncology, using randomised studies where available to establish their place in multi-modality treatment. We will not discuss their use as antiviral or immunomodulating agents in viral and autoimmune diseases, multiple sclerosis or after organ transplantation. 相似文献
8.
Radionuclide targeting and dosimetry at the microscopic level: the role of microautoradiography 总被引:1,自引:0,他引:1
Matthew R. B. Puncher Philip J. Blower 《European journal of nuclear medicine and molecular imaging》1994,21(12):1347-1365
The understanding of localisation mechanisms and microdosimetry of diagnostic and therapeutic radiopharmaceuticals depends
on knowledge of their biodistribution at the microscopic level (cellular and subcellular) in the target tissues. Various methods
have been advanced for obtaining information about this microdistribution: subcellular fractionation, secondary ion mass spectrometry
imaging, microprobe elemental analysis in the electron microscope, and microautoradiography. This review compares these approaches,
and discusses in detail the methodology of microautoradiography (the most generally useful approach) with imaging and therapy
radionuclides. Literature examples of applications of microautoradiography in nuclear medicine are reviewed, and the future
potential contribution of the techniques is assessed. 相似文献
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