全文获取类型
收费全文 | 639篇 |
免费 | 33篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 39篇 |
妇产科学 | 1篇 |
基础医学 | 80篇 |
口腔科学 | 17篇 |
临床医学 | 70篇 |
内科学 | 119篇 |
皮肤病学 | 20篇 |
神经病学 | 69篇 |
特种医学 | 122篇 |
外科学 | 36篇 |
综合类 | 14篇 |
预防医学 | 31篇 |
眼科学 | 1篇 |
药学 | 38篇 |
肿瘤学 | 33篇 |
出版年
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 14篇 |
2020年 | 3篇 |
2019年 | 2篇 |
2018年 | 3篇 |
2017年 | 7篇 |
2016年 | 8篇 |
2015年 | 12篇 |
2014年 | 14篇 |
2013年 | 20篇 |
2012年 | 9篇 |
2011年 | 13篇 |
2010年 | 31篇 |
2009年 | 37篇 |
2008年 | 13篇 |
2007年 | 28篇 |
2006年 | 21篇 |
2005年 | 14篇 |
2004年 | 14篇 |
2003年 | 6篇 |
2002年 | 9篇 |
2001年 | 13篇 |
2000年 | 4篇 |
1999年 | 9篇 |
1998年 | 37篇 |
1997年 | 37篇 |
1996年 | 30篇 |
1995年 | 29篇 |
1994年 | 14篇 |
1993年 | 19篇 |
1992年 | 12篇 |
1991年 | 14篇 |
1990年 | 14篇 |
1989年 | 20篇 |
1988年 | 27篇 |
1987年 | 19篇 |
1986年 | 13篇 |
1985年 | 17篇 |
1984年 | 8篇 |
1983年 | 7篇 |
1982年 | 12篇 |
1981年 | 5篇 |
1980年 | 10篇 |
1978年 | 11篇 |
1977年 | 11篇 |
1976年 | 7篇 |
1975年 | 5篇 |
1957年 | 1篇 |
1953年 | 1篇 |
排序方式: 共有693条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
5.
Kinnison ML; Perler BA; Kaufman SL; Mitchell SE; Kadir S; Williams GM; White RI Jr 《Radiology》1986,160(3):727-730
In situ saphenous vein grafts are being used with increasing frequency for bypass procedures involving the femoral and popliteal arteries. Complications of these procedures include anastomotic stenoses and persistent arteriovenous fistulae that may result in failure of the graft. Balloon angioplasty and embolotherapy with detachable balloons were employed successfully in three or four recent cases of patients with complications from in situ grafts. Tailored angiography is essential for evaluating in situ grafts, and interventional techniques are extremely useful for managing complications. 相似文献
6.
Cerebrospinal fluid neuropeptides in dementia. 总被引:1,自引:0,他引:1
Cerebrospinal fluid concentrations of corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone (TRH) and somatostatin (SRIF) were measured in 77 female inpatients with moderate to extreme dementia and in 17 elderly female controls. Both multi-infarct (MID) and Alzheimer-type (SDAT) demented patients had equally elevated CSF CRH and TRH but not SRIF levels as compared with the controls. This elevation was, however, not seen in patients with simple dementia while it was most prominent in those exhibiting marked depressive symptoms. It is concluded that depression rather than dementia itself may be associated with CSF CRH and TRH elevation in elderly patients with cognitive impairment. 相似文献
7.
Neurotensin is an endogenous neuropeptide that produces many CNS effects that are similar to the behavioral and physiological alterations seen after administration of antipsychotic drugs to laboratory animals. As previously reported, sub-chronic (3 week) and acute (single injection) treatment with haloperidol (1 mg/kg), a clinically effective antipsychotic drug increases neurotensin concentrations in the nucleus accumbens and the caudate nucleus. In contrast, a tricyclic antidepressant (desipramine, 10 mg/kg), an anxiolytic (chlordiazepoxide, 25 mg/kg) and a histamine H1 receptor antagonist (diphenhydramine, 20 mg/kg) did not alter neurotensin concentrations in these brain regions after sub-chronic or acute treatment. These data demonstrate pharmacologic specificity to the antipsychotic drug-induced increases in regional brain neurotensin concentrations, and support the hypothesis that these changes may contribute to the clinical efficacy of these drugs. 相似文献
8.
Garth Bissette Violetta Klimek Jun Pan Craig Stockmeier Gregory Ordway 《Neuropsychopharmacology》2003,28(7):1328-1335
Research evidence that corticotropin-releasing factor (CRF) plays a role in the pathophysiology of major depressive disorder (MDD) has accumulated over the past 20 years. The elevation of lumbar cerebrospinal fluid (CSF) concentrations of CRF decreased responsiveness of pituitary CRF receptors to challenge with synthetic CRF, and increased levels of serum cortisol in MDD subjects support the hypothesis that CRF is chronically hypersecreted in at least the endocrine circuits of the hypothalamic-pituitary-adrenal (HPA) axis and may also involve other CRF brain circuits mediating emotional responses and/or arousal. One such circuit includes the excitatory CRF input to the locus coeruleus (LC), the major source of norepinephrine in the brain. Furthermore, there are now reports of decreased levels of CRF in lumbar CSF from MDD patients after symptom relief from chronic treatment with antidepressant drugs or electroconvulsive therapy. Whether this normalization reflects therapeutic effects on both endocrine- and limbic-associated CRF circuits has not yet been effectively addressed. In this brief report, we describe increased concentrations of CRF-like immunoreactivity in micropunches of post-mortem LC from subjects with MDD symptoms as established by retrospective psychiatric diagnosis compared to nondepressed subjects matched for age and sex. 相似文献
9.
Polycystic kidney disease is an autosomal dominant disease that may be associated with cystic disease of the liver. In women, the cysts may develop early and be more troublesome than in men. Cystadenocarcinoma of the pancreas is uncommon, comprising 1% of primary pancreatic malignancies. This case report is the first to describe a familial association between polycystic kidney disease and cystadenocarcinoma of the pancreas and liver in the English medical literature. A patient with autosomal dominant polycystic kidney disease (ADPKD) and multiple hepatic cysts developed cystadenocarcinoma of the pancreas with multiple malignant liver cysts. The patient's mother, sister, and niece had ADPKD, and the patient's sister also died of pancreatic cystadenocarcinoma. We believe that the development of these two disease entities in which the primary pathology is cyst formation has a genetic association. (Gastroenterology 1997 Jun;112(6):2104-7) 相似文献
10.
Chronic treatment with atropine sulfate (20 mg/kg), atropine methyl bromide (20 mg/kg), or scopolamine (2 mg/kg) did not increase neurotensin concentrations in the nucleus accumbens or caudate nucleus. Chronic co-administration of atropine sulfate did not alter the increases in neurotensin concentrations in the nucleus accumbens and caudate nucleus produced by chronic treatment with haloperidol (1 mg/kg). The anticholinergic properties of antipsychotic drugs apparently do not mediate the increases in neurotensin concentration observed after chronic treatment with antipsychotic drugs. 相似文献