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CG Teo 《Oral diseases》2002,8(S2):88-90
Oral hairy leukoplakia (OHL) and Kaposi's sarcoma (KS) are commonly encountered in the HIV-infected patient. A unique feature of OHL is non-cytolytic high level of replication of Epstein–Barr virus (EBV) in the glossal epithelium. The expression of viral-encoded anti-apoptotic proteins concomitant to replicative proteins probably underlies this phenomenon. The question of whether OHL arises from activation of EBV latent in the tongue, or from superinfection by endogenous EBV shed via non-glossal sites or by exogenous EBV remains unresolved. Human herpesvirus 8 (HHV8) is now seen as necessary but not sufficient cause of KS. Expression of HHV8-encoded oncogenic proteins in endothelial cells probably explains the aberrant proliferation of these cells in KS lesions. Studies into why KS is so commonly observed at the palate in HIV-infected patients may provide important clues to its pathogenesis. 相似文献
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The genetic basis of polycystic ovary syndrome 总被引:11,自引:3,他引:11
Franks S; Gharani N; Waterworth D; Batty S; White D; Williamson R; McCarthy M 《Human reproduction (Oxford, England)》1997,12(12):2641-2648
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women
of reproductive age. Familial clustering of cases suggests that genetic
factors play an important part in its aetiology. A number of studies of
families with several cases of PCOS have produced results suggesting an
autosomal dominant trait. Detailed analysis of a large number of affected
families has, however, cast some doubt about the mode of inheritance. An
autosomal dominant trait remains possible but a more complex aetiology
seems more likely. The results of our recent studies support the concept of
an oligogenic disorder in which genes affecting metabolic pathways in
glucose homeostasis and steroid biosynthesis are both involved. We review
evidence for an important role for the insulin gene minisatellite in the
aetiology of anovulatory PCOS and for the gene coding for P450 cholesterol
side chain cleavage (CYP11a) in the mechanism of excessive androgen
secretion in women with polycystic ovaries. We propose that the
heterogeneity of clinical and biochemical features in PCOS can be explained
by the interaction of a small number of key genes with environmental,
particularly nutritional, factors.
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Batty K 《Hospital pharmacy》1993,28(10):1029-32, 1035-6
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This article report on a not very well-known therapeutical procedure used among only fairly diagnosed cases based on international and Hungarian experiences. In Hungary echinococcus cyst of the liver is mostly treated surgically (the average mortality rate of liver resection is 0-6.3%). In many places the percutan puncture and drainage are contraindicated in case of echinococcus cysts. The authors assert that the percutaneous treatment of echinococcus cysts in proper technical and methodic circumstances in safe regarding the previous studies and their own data obtained of a few cases, and describe the technique and raise some question in them. Drainage treatment is very well tolerated by the patients it reduces the duration (of time) and the cost of the hospitalization. 相似文献
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