排序方式： 共有18条查询结果，搜索用时 15 毫秒
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Buhtz Birnbaum Einar Sjövall Breitenecker Baniecki Lochte I. Imber Schrader Kornfeld Weimann M. Oppenheim Adolf Friedemann Lanke Ganter W. v. Baeyer Braun Eduard Krapf Martin Grotjahn Campbell Steck Kral Haymann Manfred Goldstein H. Kogerer Wexberg Merzbach Erwin Wexberg Többen Bratz Pfister Romanese Liguori Grewel Giering 《International journal of legal medicine》1933,20(4):233-243
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Nippe Klestadt Henneberg Jendralski Hans Kloiber Heidemann Foerster Trendtel Schrader Panse Schönberg G. Strassmann Hans Baumm Esser Endre Makai Arno Warstadt Hallervorden Steck Walcher Schlomka Franz Baniecki Spiecker Ernst A. Mueller P. Fraenckel Schrader Giese S. Fuhs Autoreferat Mayser Lamers Kalmus S. FuΒ Révész Panse Estler H. Scholz Schwarzacher Wierig H. E. Lorenz Lochte 《International journal of legal medicine》1935,24(2-3):168-189
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Rudolf Koch Heinr Többen Baniecki K. Tietze Matzdorff Göllner Wette Leibbrand v. Neureiter Bergemann Felix Gál J. A. Stroink L. Kraul Tapfer Walcher Voss 《International journal of legal medicine》1938,30(2-3):203-211
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Dr. Hellmuth Baniecki 《Virchows Archiv : an international journal of pathology》1932,287(2):483-490
Ohne ZusammenfassungMit 3 Abbildungen im Text. 相似文献
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Sponholz Biedermann Krauspe P. Geréb H. Brach Barth Gebhardt-Bodenstein Günther Wolf Zavka H. Löwenstädt Grauhan E. Philipp A. Salomon Baniecki Werner Hartoch Werthemann Lahm Frommolt E. Brach Robert Meyer M. Strauss Miescher 《Journal of cancer research and clinical oncology》1932,37(5-6):118-120
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New therapeutic agents for the treatment of malaria, the world's most deadly parasitic disease, are urgently needed. Malaria afflicts 300 to 500 million people and results in 1 to 2 million deaths annually, and more than 85% of all malaria-related mortality involves young children and pregnant women in sub-Saharan Africa. The emergence of multidrug-resistant parasites, especially in Plasmodium falciparum, has eroded the efficacy of almost all currently available therapeutic agents. The discovery of new drugs, including drugs with novel cellular targets, could be accelerated with a whole-organism high-throughput screen (HTS) of structurally diverse small-molecule libraries. The standard whole-organism screen is based on incorporation of [3H]hypoxanthine and has liabilities, such as limited throughput, high cost, multiple labor-intensive steps, and disposal of radioactive waste. Recently, screens have been reported that do not use radioactive incorporation, but their reporter signal is not robust enough for HTS. We report a P. falciparum growth assay that is technically simple, robust, and compatible with the automation necessary for HTS. The assay monitors DNA content by addition of the fluorescent dye 4',6-diamidino-2-phenylindole (DAPI) as a reporter of blood-stage parasite growth. This DAPI P. falciparum growth assay was used to measure the 50% inhibitory concentrations (IC50s) of a diverse set of known antimalarials. The resultant IC50s compared favorably with those obtained in the [3H]hypoxanthine incorporation assay. Over 79,000 small molecules have been tested for antiplasmodial activity using the DAPI P. falciparum growth assay, and 181 small molecules were identified as highly active against multidrug-resistant parasites. 相似文献