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排序方式: 共有273条查询结果,搜索用时 15 毫秒
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Hiroko Nagao‐Kitamoto Satoshi Nagano Sho Kitamoto Yasuhiro Ishidou Takuya Yamamoto Shunsuke Nakamura Arisa Tsuru Masahiko Abematsu Yusuke Fujimoto Masahiro Yokouchi Shinichi Kitajima Takako Yoshioka Shingo Maeda Suguru Yonezawa Setsuro Komiya Takao Setoguchi 《International journal of cancer. Journal international du cancer》2015,136(6):1276-1284
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Tomoko Akahane Kenta Masuda Akira Hirasawa Yusuke Kobayashi Arisa Ueki Miho Kawaida Kumiko Misu Kohei Nakamura Shimpei Nagai Tatsuyuki Chiyoda Wataru Yamagami Shigenori Hayashi Fumio Kataoka Kouji Banno Kokichi Sugano Hajime Okita Kenjiro Kosaki Hiroshi Nishihara Daisuke Aoki 《Journal Of Gynecologic Oncology》2022,33(4)
ObjectivePrecursor lesions may be identified in fallopian tube tissue after risk-reducing salpingo-oophorectomy (RRSO) in patients with pathogenic variants of BRCA1/2. Serous tubal intraepithelial carcinoma (STIC) is considered a precursor of high-grade serous carcinoma, whereas the significance of the p53 signature remains unclear. In this study, we investigated the relationship between the p53 signature and the risk of ovarian cancer.MethodsWe analyzed the clinicopathological findings and conducted DNA sequencing for TP53 variants of p53 signatures and STIC lesions isolated using laser capture microdissection in 13 patients with pathogenic variants of BRCA1/2 who underwent RRSO and 17 control patients with the benign gynecologic disease.Results TP53 pathogenic variants were detected significantly higher in RRSO group than control (p<0.001). No difference in the frequency of p53 signatures were observed between groups (53.8% vs 29.4%; p=0.17). TP53 sequencing and next-generation sequencing analysis in a patient with STIC and occult cancer revealed 2 TP53 mutations causing different p53 staining for STICs and another TP53 mutation shared between STIC and occult cancer.ConclusionThe sequence analysis for TP53 revealed 2 types of p53 signatures, one with a risk of progression to STIC and ovarian cancer with pathological variants in TP53 and the other with a low risk of progression without pathological variants in TP53 as seen in control. 相似文献
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Genetic Polymorphism of Plasminogen: A New Basic Variant (PLG B) and Population Study in Japanese 总被引:3,自引:0,他引:3
Dr. Hiroaki Nishimukai Yoshio Kera Kiyoshi Sakata and Kichihei Yamasawa 《Vox sanguinis》1981,40(6):422-425
Abstract. Genetic polymorphism of human plasminogen in the Japanese population was studied using agarose gel isoelectric focusing followed by immunofixation. A new basic variant, PLG B, was found as a heterozygous state PLG l-B, which was genetically determined. The allele frequencies calculated from 258 individuals were PLG1 =0.958, PLG2 =0.020 and PLGB =0.022. 相似文献
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Toshio Yamagishi Yutaka Horita Nobuhiro Mifune Hirofumi Hashimoto Yang Li Mizuho Shinada Arisa Miura Keigo Inukai Haruto Takagishi Dora Simunovic 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(50):20364-20368
The strong reciprocity model of the evolution of human cooperation has gained some acceptance, partly on the basis of support from experimental findings. The observation that unfair offers in the ultimatum game are frequently rejected constitutes an important piece of the experimental evidence for strong reciprocity. In the present study, we have challenged the idea that the rejection response in the ultimatum game provides evidence of the assumption held by strong reciprocity theorists that negative reciprocity observed in the ultimatum game is inseparably related to positive reciprocity as the two sides of a preference for fairness. The prediction of an inseparable relationship between positive and negative reciprocity was rejected on the basis of the results of a series of experiments that we conducted using the ultimatum game, the dictator game, the trust game, and the prisoner’s dilemma game. We did not find any correlation between the participants’ tendencies to reject unfair offers in the ultimatum game and their tendencies to exhibit various prosocial behaviors in the other games, including their inclinations to positively reciprocate in the trust game. The participants’ responses to postexperimental questions add support to the view that the rejection of unfair offers in the ultimatum game is a tacit strategy for avoiding the imposition of an inferior status. 相似文献
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Kitajima Yoko Maruyama-Inoue Maiko Ito Arisa Sato Shimpei Inoue Tatsuya Yamane Shin Kadonosono Kazuaki 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(6):1279-1285
Graefe's Archive for Clinical and Experimental Ophthalmology - To identify the functional outcome and evaluate the morphologic changes of patients with pachychoroid neovasculopathy (PNV)... 相似文献