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1.
Khandekar M. M. Kavatkar A. N. Patankar S. A. Bagwan I. B. Puranik S. C. Deshmukh S. D. 《Indian journal of otolaryngology and head and neck surgery》2006,58(3):246-248
Hypothesis: Analysis of salivary gland lesions by FNAC and correlation with histopathology. To evaluate utility of FNAC in salivary
gland lesions.Back ground: Salivary gland lesions form about 2–6.5% of all head and neck neoplasms in adults. They are easily accessible for FNAC (Fine
Needle Aspiration Cytology) and risks of fistula formation or tumour implantation are low compared surgical biopsy. Also,
cytology can provide a distinction between asalivary and non salivary lesion, benign and malignant lesions so also specific
and non specific inflammation.
Methods: Seventy patients were studied prospectively over two years. FNAC was done using 10 cc syringes and 20–22 no. needle. Histomorphology
was assessed on routine H & E (haemotxylin and eosin) stained paraffin sections. SPAS (periodic acid Schiff) and mucicarmine
satins were also done.
Results: 80% of the lesions were neoplastic (61% benign, 31% malignant) and 20% were neoplastic. Pleomorphic adenoma was the most
frequent benign neoplasm while mucoepidermoid carcinoma was the most frequent malignant lesion. Among the non neoplastic lesions,
the maximum number of cases were of chronic sialadentis. In the present study, FNAC has a sensitivity of 94.54% and specificity
of 80.95% for neoplastic lesions.
Conclusions: FNAC was found to be a useful diagnostic tool in the evaluation of salivary gland lesions because of its simplicity, excellent
patient compliance and rapid diagnosis. This cost effective tool is invaluable in planning the surgical management of the
patient. 相似文献
2.
This report describes a case of manic symptoms induced by olanzapine in an 85-year-old female with a 3 year history of delusional disorder. She was treated in the past with trifluoperazine and risperidone. Symptoms were severe enough to require detention in hospital. Florid manic symptoms resolved two weeks after stopping olanzapine while only using 1 mg of haloperidol as required. 相似文献
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Shaila C. Puranik Kalpana B. Rathod Jyoti K. Kudrimoti 《Indian journal of hematology & blood transfusion》2014,30(1):51-53
We are presenting a rare case of toxoplasma lymphadenopathy with hyper viscosity syndrome due to polyclonal gammopathy. A 30 year old female presented with generalized lymphadenopathy. Lymph node biopsy findings suggestive of toxoplasmosis were confirmed on serology. Bone marrow aspiration showed 50 % plasma cells. On serum electrophoresis broad, diffuse band noted, indicative of polyclonal gammopathy. M band was absent. The patient was immunocompetent and presented with hyper viscosity syndrome masking the symptoms of underlying toxoplasmosis. 相似文献
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E. coli AlkB, a repair enzyme of the dioxygenase family, catalyses the removal of mutagenic methylated nucleotides from the genome. Known for substrate promiscuity, AlkB''s catalytic mechanism and conformational changes accompanying substrate binding have been extensively dissected. However, the structural parameters of various substrates governing their recognition by AlkB still remain elusive. In this work, through solution-state vibrational spectra of methylated substrates bound to AlkB in combination with computational analysis, we show that the recognition specificity is dictated by the protonation states of the substrates. Specificity is conferred predominantly through hydrogen bonding and cation–π interactions. Furthermore, we report on the interaction of AlkB with normal, unmodified nucleotides, wherein the presence of an exocyclic amino group serves as an essential criterion for the initial process of substrate recognition. Taken together, these results provide a rationale for structural determinants of substrate specificity as well as mode of lesion discrimination employed by AlkB.Positive charge on methylated nucleotides is a prime criterion for substrate recognition by E. coli AlkB. 相似文献
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Wenjun Kang Sabah Kadri Rutika Puranik Michelle N. Wurst Sushant A. Patil Ibro Mujacic Sonia Benhamed Nifang Niu Chao Jie Zhen Bekim Ameti Bradley C. Long Filipo Galbo David Montes Crystal Iracheta Venessa L. Gamboa Daisy Lopez Michael Yourshaw Carolyn A. Lawrence Jeremy P. Segal 《The Journal of molecular diagnostics : JMD》2018,20(4):522-532
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