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排序方式: 共有391条查询结果,搜索用时 15 毫秒
1.
Computer-derived equations for predicting survival postoperatively. Their usefulness and limitations
E B Rypins F Khan D Collins-Irby I J Sarfeh J T Ashurst E A Stemmer 《Archives of surgery (Chicago, Ill. : 1960)》1988,123(3):354-357
We used multivariate analysis to determine whether survival following perforations of the gastrointestinal tract could be accurately predicted from preoperative data. Of 12 variables tested, four were found to have predictive value. These were age, pulmonary disease, preoperative shock, and the attending surgeon. When these four variables were employed in a logistic regression equation on 42 patients, it correctly predicted which 21 patients died before leaving the hospital. To produce an equation useful for other hospitals, we recalculated it without the attending surgeon variable. Again, the equation was used to predict survival. The correlation of predicted vs observed outcome remained high, and, using a 2 x 2 chi 2 test, the correlation was significant. We then cross validated the three-variable model on data from a second hospital. The model accurately predicted the new data equally well. We believe that predictive models can identify risk factors in a variety of patient populations and can determine who is likely to benefit from specific treatment modalities. 相似文献
2.
Alto WA 《Papua and New Guinea medical journal》1996,39(4):315-320
Locally directed, decentralized health services offer opportunities for empowerment by defining priorities based on community-derived policies. These are the components of the Primary Health Care Approach still missing in Melanesia. 相似文献
3.
R. K. Davis Ph.D. A. W. Horton Ph.D. E. E. Larson Ch.E. K. L. Stemmer M.D. 《Archives of environmental & occupational health》2013,68(4):473-479
In a study of the specificity of the iodine-azide reaction in carbon disulfide (CS2) exposure, iodine-azide reaction and dithiocarb (sodium diethyidithiocarbamate) in the urine of alcoholics treated with disulfiram (tetraethylthiuram disulfide) were determined. After application of disulfiram, the iodine-azide reaction was negative 40% of the time, but some dithiocarb is always present in urine. Therefore, dithiocarb determination could be used to measure the patient’s discipline. The great dispersion of dithiocarb results is discussed as a possible influence of pathologic condition and compared with other drugs, especially, meprobamate. The application of meprobamate increased the percentage of positive iodine-azide reaction in disulfiram, treated alcoholics, but dispersion of dithiocarb results was the same as in alcoholics not using meprobamate. The iodine-azide test (IAT) does not provide a satisfactory index of exposure in individuals taking disulfiram for alcoholism. 相似文献
4.
Lawrence G. Rudski Luna Gargani William F. Armstrong Patrizio Lancellotti Steven J. Lester Ekkehard Grünig Michele DAlto Meriam ?str?m Aneq Francesco Ferrara Rajeev Saggar Rajan Saggar Robert Naeije Eugenio Picano Nelson B. Schiller Eduardo Bossone 《Journal of the American Society of Echocardiography》2018,31(5):527-550.e11
5.
Alice dos Santos Rosa BSc Luana Graziella Bandeira BSc Andréa Monte‐Alto‐Costa PhD Bruna Romana‐Souza PhD 《Wound repair and regeneration》2014,22(4):537-547
Supplementation with olive and fish oils reverses the effects of stress on behavioral activities and adrenal activation. However, previous studies have not shown whether supplementation with olive and fish oil could inhibit the effects of stress on cutaneous wound healing. Thus, this study investigated the effects of supplementation with fish or olive oil on cutaneous healing in stressed mice. Mice were subjected to rotational stress and treated with olive or fish oil daily until euthanasia. An excisional lesion was created on each mouse, and 14 days later, the lesions were analyzed. In addition, murine skin fibroblasts were exposed to elevated epinephrine levels plus olive oil, and fibroblast activity was evaluated. In the in vivo studies, administration of olive oil, but not fish oil, inhibited stress‐induced reduction in wound contraction, reepithelialization, hydroxyproline levels, and blood vessel density. Stress‐induced increases in vascular endothelial growth factor expression and the numbers of macrophages and neutrophils were reversed only by olive oil. Both oils reversed stress‐induced increase in catecholamine levels and oxidative damage. In in vitro studies, olive oil treatment reversed the reduction in fibroblast migration and collagen deposition and the increase in lipid peroxidation induced by epinephrine. In conclusion, supplementation with olive oil, but not fish oil, improves cutaneous wound healing in chronically stressed mice. 相似文献
6.
Antonello D’Andrea Juri Radmilovic Stefano Caselli Andreina Carbone Raffaella Scarafile Simona Sperlongano Giampaolo Tocci Tiziana Formisano Francesca Martone Biagio Liccardo Michele D’Alto Eduardo Bossone Maurizio Galderisi Paolo Golino 《The international journal of cardiovascular imaging》2018,34(10):1561-1561
7.
Sarubbi Berardo Colonna Diego Correra Anna Romeo Emanuele D’Alto Michele Palladino Maria Teresa Virno Salvatore D’Onofrio Antonio Russo Maria Giovanna 《Journal of interventional cardiac electrophysiology》2022,63(2):283-293
Journal of Interventional Cardiac Electrophysiology - Implantable cardioverter defibrillators (ICD) are widely accepted therapy in children and adolescents who are survivors of cardiac arrest or... 相似文献
8.
Bruna Romana‐Souza Adriana P. Nascimento Patricia C. Brum Andréa Monte‐Alto‐Costa 《International journal of experimental pathology》2014,95(5):330-341
The α2‐adrenoceptors regulate the sympathetic nervous system, controlling presynaptic catecholamine release. However, the role of the α2‐adrenoceptors in cutaneous wound healing is poorly understood. Mice lacking both the α2A/α2C‐adrenoceptors were used to evaluate the participation of the α2‐adrenoceptor during cutaneous wound healing. A full‐thickness excisional lesion was performed on the dorsal skin of the α2A/α2C‐adrenoceptor knockout and wild‐type mice. Seven or fourteen days later, the animals were euthanized and the lesions were formalin‐fixed and paraffin‐embedded or frozen. Murine skin fibroblasts were also isolated from α2A/α2C‐adrenoceptor knockout and wild‐type mice, and fibroblast activity was evaluated. The in vivo study demonstrated that α2A/α2C‐adrenoceptor depletion accelerated wound contraction and re‐epithelialization. A reduction in the number of neutrophils and macrophages was observed in the α2A/α2C‐adrenoceptor knockout mice compared with wild‐type mice. In addition, α2A/α2C‐adrenoceptor depletion enhanced the levels of nitrite and hydroxyproline, and the protein expression of transforming growth factor‐β and vascular endothelial growth factor. Furthermore, α2A/α2C‐adrenoceptor depletion accelerated blood vessel formation and myofibroblast differentiation. The in vitro study demonstrated that skin fibroblasts isolated from α2A/α2C‐adrenoceptor knockout mice exhibited enhanced cell migration, α‐smooth muscle actin _protein expression and collagen deposition compared with wild‐type skin fibroblasts. In conclusion, α2A/α2C‐adrenoceptor deletion accelerates cutaneous wound healing in mice. 相似文献
9.
Alane B. O’Connor Liam O’Brien William A. Alto Jacqueline Wong 《The journal of maternal-fetal & neonatal medicine》2016,29(1):112-114
Objective: To determine whether concurrent in utero exposure to buprenorphine and antidepressants impacts the course of neonatal abstinence syndrome (NAS) in infants.Methods: A retrospective cohort study of 148 infants who were exposed to buprenorphine during pregnancy. Univariate and bivariate analyses were used to examine associations between concurrent maternal use of buprenorphine and antidepressants as compared to maternal use of buprenorphine alone.Results: The time to onset of NAS resolution was significantly longer in infants exposed to both buprenorphine and antidepressants during pregnancy when compared to those exposed to buprenorphine alone (129.8?h versus 70.2?h, p?=?0.042).Conclusions: Women who are prescribed both antidepressants and buprenorphine during pregnancy should be counseled about the possibility of a prolonged course of neonatal abstinence syndrome. 相似文献
10.
Battaglia Parodi Maurizio Romano Francesco Arrigo Alessandro Di Nunzio Carlo Buzzotta Alessio Alto Giorgio Bandello Francesco 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(2):297-301
Graefe's Archive for Clinical and Experimental Ophthalmology - The vitelliform stage is the typical phenotypic manifestation of Best vitelliform macular dystrophy (BVMD). As yet, no study has... 相似文献