全文获取类型
收费全文 | 5504篇 |
免费 | 295篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 58篇 |
儿科学 | 272篇 |
妇产科学 | 82篇 |
基础医学 | 455篇 |
口腔科学 | 90篇 |
临床医学 | 404篇 |
内科学 | 1439篇 |
皮肤病学 | 106篇 |
神经病学 | 309篇 |
特种医学 | 169篇 |
外科学 | 964篇 |
综合类 | 140篇 |
一般理论 | 3篇 |
预防医学 | 209篇 |
眼科学 | 200篇 |
药学 | 404篇 |
中国医学 | 24篇 |
肿瘤学 | 494篇 |
出版年
2024年 | 5篇 |
2023年 | 54篇 |
2022年 | 119篇 |
2021年 | 244篇 |
2020年 | 155篇 |
2019年 | 203篇 |
2018年 | 223篇 |
2017年 | 139篇 |
2016年 | 197篇 |
2015年 | 170篇 |
2014年 | 282篇 |
2013年 | 331篇 |
2012年 | 489篇 |
2011年 | 474篇 |
2010年 | 297篇 |
2009年 | 240篇 |
2008年 | 377篇 |
2007年 | 374篇 |
2006年 | 269篇 |
2005年 | 263篇 |
2004年 | 216篇 |
2003年 | 167篇 |
2002年 | 148篇 |
2001年 | 43篇 |
2000年 | 37篇 |
1999年 | 33篇 |
1998年 | 25篇 |
1997年 | 17篇 |
1996年 | 28篇 |
1995年 | 18篇 |
1994年 | 12篇 |
1993年 | 14篇 |
1992年 | 21篇 |
1991年 | 20篇 |
1990年 | 21篇 |
1989年 | 12篇 |
1988年 | 14篇 |
1987年 | 4篇 |
1986年 | 5篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1980年 | 6篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 6篇 |
1976年 | 5篇 |
1975年 | 4篇 |
1972年 | 4篇 |
1966年 | 5篇 |
1965年 | 3篇 |
排序方式: 共有5822条查询结果,搜索用时 46 毫秒
1.
2.
Uday Yanamandra Prateek Deo Kamal Kant Sahu Ram Vasudevan Nampoothiri Nalini Gupta Anusree Prabhakaran Deb Prasad Dhibhar Alka Khadwal Gaurav Prakash Man Upadesh Singh Sachdeva Deepesh Lad Neelam Varma Subhash Varma Pankaj Malhotra 《Clinical Lymphoma, Myeloma & Leukemia》2019,19(3):183-189.e1
Background
Multiple myeloma (MM) is a hematologic malignancy of plasma cell origin. MM primarily affects bone marrow, but extramedullary sites can also be involved. Myelomatous pleural effusion (MPE) is an atypical and rare complication of MM. We aimed to systematically study the incidence and clinicopathologic profile of patients with MPE in a real-world setting.Patients and Methods
In this retrospective study, 415 consecutive patients with MM managed at a tertiary care center in North India during a study period of January 1, 2010 to December 31, 2015 were evaluated for MPE. The patients with MPE were analyzed for their clinical profile, diagnosis, treatment, and outcomes.Results
Of these 415 patients, 11 (2.65%) patients had MPE. The median age of the study population was 50 years with male preponderance. The majority of these patients had immunoglobin (Ig)G Kappa disease. All patients had higher than International Staging System stage I disease. MPE was a presenting feature at MM diagnosis in 45.45% (n = 5) of the patients, whereas the rest developed MPE during follow-up. MPE presented predominantly (81.8%) as a unilateral effusion. Concurrent extramedullary involvement at other site was seen in 45.45% (n = 5), with 3 (27%) patients having concurrent myelomatous ascites. Six of these were managed aggressively, whereas 5 patients opted for palliation. The outcomes were dismal (90.9% mortality), with a median survival of 2.47 months.Conclusion
MPE is a rare entity, and positive outcomes of therapy remain low with dismal prognosis. 相似文献3.
D. Panigrahy P. K. Sahu 《Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine》2016,39(3):783-795
Electrocardiogram (ECG) signal gives a lot of information on the physiology of heart. In reality, noise from various sources interfere with the ECG signal. To get the correct information on physiology of the heart, noise cancellation of the ECG signal is required. In this paper, the effectiveness of extended Kalman smoother (EKS) with the differential evolution (DE) technique for noise cancellation of the ECG signal is investigated. DE is used as an automatic parameter selection method for the selection of ten optimized components of the ECG signal, and those are used to create the ECG signal according to the real ECG signal. These parameters are used by the EKS for the development of the state equation and also for initialization of the parameters of EKS. EKS framework is used for denoising the ECG signal from the single channel. The effectiveness of proposed noise cancellation technique has been evaluated by adding white, colored Gaussian noise and real muscle artifact noise at different SNR to some visually clean ECG signals from the MIT-BIH arrhythmia database. The proposed noise cancellation technique of ECG signal shows better signal to noise ratio (SNR) improvement, lesser mean square error (MSE) and percent of distortion (PRD) compared to other well-known methods. 相似文献
4.
5.
6.
Ajay Punpale C S Pramesh Nirmala Jambhekar Rajesh C Mistry 《Annals of thoracic and cardiovascular surgery》2006,12(6):425-427
Liposarcomas are extremely rare in the mediastinum. They may achieve considerable size before causing any symptoms. Mediastinal liposarcomas may invade surrounding structures like the pericardium or the superior vena cava. Complete surgical excision is the optimal treatment in resectable cases. Excision of adjacent structures like the pericardium may be needed if the tumor infiltrates them. We report on a case of a giant liposarcoma of the mediastinum involving both hemithoraces and extending into the neck, which was successfully managed by complete surgical excision. 相似文献
7.
Since the first transurethral resection of the prostate (TURP) was performed by Guyon at the Necker Hospital in Paris in 1901,
this treatment modality has replaced open prostatectomy as the procedure of choice for more than 95% of patients. TURP has
been used in surgical treatment of benign prostatic hyperplasia (BPH) and remains the gold standard treatment. Transurethral
vapor resection of the prostate (TUVRP) and holmium laser enucleation of the prostate (HoLEP) are new treatment modalities
for the treatment of BPH. Each procedure has its own advantages and disadvantages. Availability of instruments, surgical expertise,
and specific indications for a particular procedure are of utmost importance for successful outcome, with minimal morbidity.
TURP can be either monopolar or bipolar, using thin or thick loop. Bipolar TURP is associated with less bleeding and less
chances of dilutional hyponatremia. TUVRP, using a thick wedge loop, causes vaporization and resection of the prostate, and
is associated with less bleeding and short operative time. HoLEP is another effective alternative for the surgical treatment
of BPH. The holmium laser possesses the ideal combination of cutting and coagulation; however, it has a learning curve. 相似文献
9.
A 50 year old man with a two month history of upper abdominal pain and a one month history of anorexia and weight loss, presented
with icterus and evidence of peritonitis. Laparotomy revealed biliary peritonitis which had been caused by a rupture of the
fundus of the gallbladder. The common bile duct was dilated and there was a large growth in the head of the pancreas with
multiple hepatic metastases. A cholecysto-jejunostomy and gastrojejunostomy were done and the patient had an uneventful recovery. 相似文献
10.
S C Sahu 《Biomedical and environmental sciences : BES》1990,3(2):183-201
The role that free radicals in general and oxygen radicals in particular play in carcinogenesis has attracted considerable attention in recent years. The oxygen radicals are undesirable but inevitable products of aerobic metabolism in the normal living cell. The cellular antioxidant defense system maintains an appropriate balance between necessary oxidative events and those that are excessive. When this critical balance cannot be maintained because of the overloading of the cellular redox system, oxygen radicals can induce cell damage. They can influence carcinogenesis by inducing DNA damage from direct oxidation or indirectly from DNA-binding products of lipid peroxidation. Oxygen radicals can induce conformational changes in the plasma membrane by lipid peroxidation and protein degradation, thus influencing membrane-associated cellular activities. They are capable of affecting membrane-bound protein kinases, growth factors and their receptors, and, therefore, signal transduction and oncogene activation. Thus, the oxygen radicals can have a major influence on oncogenes and oncogenesis. 相似文献