海员肺功能相关影响因素调查分析

Objective To investigate and analyze factors influencing the pulmonary function of seafarers. Methods The pulmonary function of seafarers and the control group was measured by Jaeger MS Diffusion Pulmonary Function Analyzer and the influencing factors were also investigated. Results Pulmonary function of seafarers decreased as the length of service increased, but had no significant differences. FEV1, FEV1/FVC ,PEF and MVV of the seafarers who smoked were significantly less than those who didn't smoke. FVC, FEV1/FTC and MVV of seafarers who worked in cabins were significantly lower than those who worked ondeck. The pulmonary funetion of seafarers who smoked were worse than that of the workers on the land, hutwithout significant difference. FEFso～ and FEF～ of seafarers who didn' t smoke were significantly lower thanthose of the workers on the land who didn' t smoke. Conclusions Smoking and work environment are thefactors influencing pulmonary function of seafarers, to which more attention should be paid.     

盐酸纳洛酮治疗急性酒精中毒61例临床分析

目的：观察盐酸纳洛酮对急性酒精中毒的治疗作用。方法：选择我院1995年4月至2006年12月间的急性酒精中毒患者118例，随世分挚要组．治疗组给予盐酸纳洛酮静脉注射及静脉滴注，对照组给予极化液静脉滴注，测定其显效时间、症状减轻时间和症状消失时间。结果：治疗组在病人清醒时间及出院时间方面均短于对照组。结论：盐酸纳洛酮治疗急性酒精中毒安全有效。     

胸导R波递增不良对前壁心肌梗死患者诊断价值

目的探讨胸导R波递增不良对前壁心肌梗死患者的诊断价值。方法通过回顾笔者所在医院2009年5月~2011年12月住院患者中心电图检查出现胸导R波递增不良患者100例,进行资料再分析。结果 100例患者,行三磷酸腺苷MPI检查,共检出前壁心肌梗死患者44例,冠心病26例,其余未发现心肌梗死。两种患者通过Marquett、Zema、DePace、Warmer标准、10项新标准评定,观察两组检出率,器质性组明显高于无器质性组检出率,且两组对比,差异明显,具有统计学意义(P<0.05)。结论对于胸导R波递增不良患者,运用Marquett、Zema、DePace及Warmer常规标准及10项新标准判定,无论是联合判定还是单纯判定,都不能完全确定为前壁心肌梗死,诊断价值有限,需结合临床进一步检验。     

海员肺功能相关影响因素调查分析

目的 调查海员的肺通气功能情况及其影响因素.方法 采用Jaeger MS Diffusion型肺功能仪测定海员及陆地工作人员的肺通气功能,分析其影响因素.结果 海员的肺功能随工龄段的增加有所下降,但无明显差异.海员吸烟者与不吸烟者肺功能比较,第1秒用力肺活量(FEV1)、第1秒用力肺活量百分比(FEV1/FVC)、最大呼气流量(PEF)、最大肺活量(MVV)均有降低,差异有统计学意义(P<0.05).机舱工作者肺功能指标FVC、FEV1/FVC、MVV低于甲板工作者,差异有统计学意义(P<0.05).海员吸烟者肺功能与陆地工作吸烟者肺功能相比各项指标有降低,但差异无统计学意义,海员不吸烟者与陆地不吸烟者比较,FEF_(50%)和FEF_(25%)有降低,差异有统计学意义(P<0.05).结论 吸烟及工作环境对海员肺通气功能有一定影响,应予以重视.     

海员肺功能相关影响因素调查分析

Objective To investigate and analyze factors influencing the pulmonary function of seafarers. Methods The pulmonary function of seafarers and the control group was measured by Jaeger MS Diffusion Pulmonary Function Analyzer and the influencing factors were also investigated. Results Pulmonary function of seafarers decreased as the length of service increased, but had no significant differences. FEV1, FEV1/FVC ,PEF and MVV of the seafarers who smoked were significantly less than those who didn't smoke. FVC, FEV1/FTC and MVV of seafarers who worked in cabins were significantly lower than those who worked ondeck. The pulmonary funetion of seafarers who smoked were worse than that of the workers on the land, hutwithout significant difference. FEFso～ and FEF～ of seafarers who didn' t smoke were significantly lower thanthose of the workers on the land who didn' t smoke. Conclusions Smoking and work environment are thefactors influencing pulmonary function of seafarers, to which more attention should be paid.     

基于核因子NF-E2相关因子/血红素氧合酶-1信号通路研究丁苯酞对糖尿病脑小血管病大鼠的作用机制

目的:通过核因子NF-E2相关因子(Nrf2)/血红素氧合酶-1(HO-1)信号通路研究丁苯酞治疗糖尿病脑小血管病大鼠的作用机制。方法:将建模成功的糖尿病脑小血管病大鼠随机分为丁苯酞治疗组和模型组，行水迷宫实验，取材后石蜡切片染色、脱水封片，显微镜观察大鼠大脑皮质的组织学结构及该区域神经元细胞的组织病理学改变；应用Western blot法检测脑组织Nrf2/HO-1信号通路中Nrf2和HO-1蛋白表达。结果:水迷宫实验d 1～d 4,与模型组相比，丁苯酞治疗组大鼠定位航行实验逃避潜伏期逐渐缩短。脑组织镜下观察，与模型组相比，丁苯酞治疗组大鼠脑组织细胞排列规则、细胞核饱满圆润、固缩现象减少。Western blot法检测发现，与模型组相比，丁苯酞治疗组大鼠脑组织中Nrf2和HO-1蛋白表达增高。结论:丁苯酞治疗组大鼠脑组织中Nrf2和HO-1增加，表明丁苯酞可能通过上调抗氧化应激蛋白的表达发挥脑保护作用。