排序方式: 共有20条查询结果,搜索用时 0 毫秒
1.
2.
3.
4.
BACKGROUND: Common strategies for preventing diabetic nephropathy include effective control of blood sugar and blood pressure, inhibition of the rennin-angiotensin system and lipid-lowering therapy, but it is often difficult to get the desired results.
OBJECTIVE: To investigate the effect of transplantation of bone marrow mesenchymal stem cells on levels of blood glucose and urinary total protein in diabetic nephropathy rats.
METHODS: Forty-five Sprague-Dawley rats were randomly divided into three groups (n=15 per group): normal control group, diabetic nephropathy group and stem cell transplantation group. Rats in the diabetic nephropathy and stem cell transplantation groups were given single use of 60 mg/kg streptozotocin to make diabetic nephropathy models. The same dose of citric acid-sodium citrate buffer was injected in the normal control group. After modeling, 200 μL of bone marrow mesenchymal stem cell solution (2×106) was injected into the left ventricle of rats in the stem cell transplantation group, and then at 7 days after the first transplantation, the cell transplantation was conducted again. The same dose of serum-free L-DMEM was injected intracardially into the rats in the normal control and diabetic nephropathy groups. Levels of urinary total protein and blood glucose were detected.
RESULTS AND CONCLUSION: At 1, 4, 8 weeks after treatment, the urinary total protein and blood glucose levels were significantly higher in the stem cell transplantation group and diabetic nephropathy group than the normal control group (P < 0.05). At 1 week after treatment, the urinary total protein and blood glucose levels were significantly lower in the stem cell transplantation group than the diabetic nephropathy group (P < 0.05). At 4 and 8 weeks after treatment, the total urinary protein and blood glucose levels were slightly higher in the diabetic nephropathy group than the stem cell transplantation group, but there was no significant difference (P > 0.05). These findings indicate that bone marrow mesenchymal stem cell transplantation in diabetic nephropathy rats can get good results in a short period, significantly improve the blood glucose and urinary total protein levels, but the long-term treatment effect is poor. 相似文献
5.
抗利尿激素分泌失调综合征为首发的肺癌临床观察 总被引:1,自引:0,他引:1
抗利尿激素分泌失调综合征(syndrome of inappropriate antidiuretic hormone secretion, SIADH) 是指内源性抗利尿激素(ADH),即精氨酸加压素(AVP)或类ADH样物质分泌过多,使得水的排泄发生障碍,从而导致水潴留、尿排钠增多以及稀释性低钠血症等有关临床表现的一组综合征。SIADH的起病隐匿,多继发于肿瘤,尤其是肺癌。临床上容易被忽视及漏诊。现将我院8年来收治的16例以SIADH为首发的肺癌患者的临床资料报道如下。 相似文献
6.
7.
8.
目的 研究2型糖尿病患者中腹内脂肪组织( VAT)和皮下脂肪组织(SAT)与体重指数(BMI)及全身炎症反应标记物间的关系.方法 通过多层螺旋CT扫描来确定2型糖尿病患者VAT、SAT的分布状态,评价炎症反应标记物与C反应蛋白(CRP)、BMI、VAT及SAT间的关系.结果 在2型糖尿病受试者中BMI和VAT均与炎症标记物相关.SAT与全身炎症反应标记物没有相关关系.而且除了BMI之外,VAT提供了更多与血管重塑及血液高凝有密切关系的许多全身组织炎症标记物的信息.结论 在2型糖尿病患者中脂肪组织分布是全身炎症反应的重要决定因素. 相似文献
9.
背景:1型糖尿病是一种自身免疫性疾病,以胰腺β细胞选择性破坏,导致患者体内胰岛素分泌绝对不足为特征。脐血干细胞具有多分化潜能,在体内外均可以诱导分化为胰岛细胞,发挥出一定的降糖作用。目的:探讨脐血干细胞对1型糖尿病大鼠血糖水平及胰腺组织PDX-1、MafA表达的影响。方法:30只SD大鼠随机分为3组,每组10只,治疗组和模型组大鼠建立1型糖尿病模型,造模成功后,治疗组尾静脉一次性注射脐血干细胞,正常组给予相同体积的生理盐水,模型组给予相同体积的脐血干细胞缓冲液。采用口服葡萄糖耐量试验评价大鼠胰岛功能,苏木精-伊红染色观察大鼠胰腺形态,Western blot 和PCR 检测胰腺组织PDX-1、MafA蛋白和mRNA表达。结果与结论:①模型组和治疗组大鼠0,30,60,90 min的血糖值均显著高于正常组,差异均有显著性意义(P < 0.05);120 min时间点模型组血糖值显著高于正常组(P < 0.05);治疗组则与正常组之间差异无显著性意义(P > 0.05)。②模型组胰岛数量出现下降,边界模糊不清,呈不规则形态,治疗组胰岛数量出现一定的减少,但尚维持清晰的结构。③治疗组PDX-1及MafA表达水平与正常组比较差异无显著性意义(P > 0.05),但显著高于模型组(P < 0.05)。以上结果表明,脐血干细胞可以显著降低1型糖尿病大鼠的血糖水平,改善胰岛功能及胰腺组织形态,并具有上调PDX-1、MafA表达的作用。中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程 相似文献
10.