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A series of compounds was synthesized, these compounds were tested for Hela-S3cells in vitro for radiosensitizing activity. Five of them are 2,2′- (arylimino)-diethyl-sodium thio-sulfate and two of them are phenylalanine derivatives. Most of them showed various degrees of ra-diosensitizing activity. Among them, SER of L07 was 1.89 at 3 mmol, and had low cytotoxicity toHela-S3 cells;ID50 was 18.8 mmol. The relationship between radiosensitizing effects and chemicalstructure was discussed. It offers a base for further exploration of selectively hypoxic cell radiosens-itizers. 相似文献
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以HeLa-S_3离体细胞研究了2.2'(间硝基苯亚胺)二乙基硫代硫酸钠(S-8820)和N-(5-硝基苯骈咪唑-2甲基)亚氨基二乙酸三钠盐(S-8928)两种结构不同的化合物的放射增敏效果。结果表明两种化合物的离体细胞毒性均较低,ID_(50)分别为12.5mmol/L和1.57mmol/L。对乏氧细胞的放射增敏作用S-8928优于S-8820,SER分别为1.47(1/10ID_ (50))和1.32(1/5ID_(50))。两化合物增敏效果与浓度的依赖关系不同,S-8820的增敏效应随浓度而增高,而S-8928随浓度而减小,呈反相关系。机理待研究。 相似文献
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为寻找有效的乏氧细胞放射增敏剂,我们设计和合成出了七个新型化合物,其中五个是2,2'-(芳亚胺基)二乙基硫代硫酸钠的系列化合物,两个是苯丙氨酸类衍生物,并试验了它们对离体HeLa-S_3细胞的放射增敏作用。在化学合成中,分别以前体物N,N-双(β氯乙基)取代苯胺与硫化硫酸钠反应,即得L01-L04及 相似文献
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刘汇辛 《国际放射医学核医学杂志》1993,(2)
化合物2-硝基咪唑1-乙酰氧肟酸钾盐(KIH-802)是MISO的改造物,其中对KIH-802的药代动力学进行了研究。采用ICR小鼠,KIH-802[2’-~(14)C]100mg/kg(24.1kBq/mg)静脉给药,以液 相似文献
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