儿童急性嗜碱粒细胞性白血病1例

儿童急性嗜碱粒细胞性白血病１例连学顺，冉崇蓉患者赵某，男性，８岁，主因发热７天，四肢疼痛５天于１９９４年１月１９日入院。患儿于入院前一周无明显诱因开始发热，体温高达３９℃，无抽搐、头痛、呕吐，无咳嗽、喘息，在当地卫生院按感冒治疗无效并出现四肢关节疼痛...     

原始周围神经外胚层肿瘤1例

1　病例报告患儿男,6岁,因发现左前臂肿物1个月入院。1个月前发现左前臂肿物,表面隆起,无红肿、疼痛及发热等,肿物渐增大。入院时查体:精神好,无皮疹,浅表淋巴结不大,心肺无异常,腹平软,肝脾不大,左前臂肿物约5cm×3cm,轻度压疼,表面无红肿,质韧,边界不清,基底深,上肢活动无异常。CT示:肿物与尺、挠骨无联系。血管造影:距桡骨上端约1cm下外侧见一类椭圆形肿物。约4cm×2.8cm,边界欠清楚。周围血管纡曲增多。入院后手术切除,术中见肿物位于肌肉间,无包膜,约4cm×3cm×3cm,与周围组织粘连,尤以深层桡骨膜粘连明显,骨皮质增厚。病理检查:原始…     

双苓止泻口服液治疗小儿肠炎的疗效

我们于１９９９年１０月至２０００年１月对双苓止泻口服液(太极集团涪陵制药厂生产,批号:９９０７１５)治疗小儿肠炎的疗效进行了临床观察,现将观察结果总结如下:     

联合大/中剂量氨甲喋呤治疗小儿急性淋巴细胞白血病的近期和远期疗效观察

近十年我们联合应用大/中剂量氨甲喋吟(H/ID—MTX)治疗小儿急性淋巴细胞白血病(ALL)取得较好的疗效。10例初治 ALL 用 H/ID—MTX 治疗与15例未用 H/ID—MTX 对照,Kaplan～Meier 分析显示前者无病生存期较后者为长(P<0.05)。12例复发 ALL 用 H/ID—MTX 治疗(16例次)有效率为93.75%(15/16)。H/ID—MTX 近期副作用是可逆的。本文118例次 H/ID—MTX 治疗中无一例发生药物性死亡。     

白血病患者细胞增殖周期临床意义的探讨

近年来,国外采用分子生物学和细胞遗传学相结合的方法,建立了 BrdU(5溴脱氧尿嘧啶核苷)标记染色体测定细胞增殖周期技术。根据 DNA 半保留复制的特性和碱基类似物 BrdU 能替代胸腺嘧啶核苷掺入 DNA的原理,可以通过染色单体分化染色的受色类型判断细胞群体的增殖速率。这一技术已用于观察白血病人细胞增殖动力学变化,对     

粒－单细胞集落刺激因子在自体外周血干细胞移植中的临床应用

报告小儿自体外周血干细胞移植及化疗中粒。单细胞集落刺激因子（ＧＭ－ＣＳＦ）的临床应用研究，共２０例（２４次），并设对照组比较。结果：移植前用作动员剂９例。粒、单系祖细胞（ＣＦＵ－ＧＭ）产率提高平均２９倍，自体外周血每次采集的ＣＦＵ－ＧＭ数较对照组有显著提高（Ｐ＜０．０５）；用于移植后早期４例（６次），白细胞恢复天数较对照组明显缩短（Ｐ＜０．０５）；用于移植后中期及恢复期３例（４次），２例造血恢复，１例（２次）有短期疗效。用于化疗后白细胞减低者效果显著，副反应轻。认为ＧＭ－ＣＳＦ有明显动员外周血干细胞作用，用于移植后可促进造血功能恢复，提高移植的安全性。     

Application of autologous peripheral blood stem cell transplantation in children with malignant tumor

Objective To investigate if low dose total body irradiation (TBI, 6.0-9.0 Gy) combined with intensified chemotherapy followed by autologous peripheral blood stem cell transplantation results in better survival in children with refractory leukemia or solid tumors. Methods Twenty-one children with malignant tumors were included in this study.There w ere 14 males and 7 females aged 3.5-12 years.Underlying disease included high -risk acute lymphoblastic leukemia (ALL, CR(1) in 3 children and CR(2) in 5 ch ildren), acute myeloblastic leukemia (AML, 9 children), non-Hodgkin’s lymphoma stage Ⅳ ( 2 children), and neuroblastoma stage Ⅳ (2 children).The peripheral hematopoi etic stem cells were collected six to eleven months after complete response, mob ilized with high dose chemotherapy alone or combined with GM-CSF or G-CSF.Th e conditioning regimen consisted of chemotherapy with two to three combinations of the following drugs: cyclophosphamide, arabinosylcytosine, McNU, etopside, an d Idarubicin on the basis ofTBI (6.0-9.0 Gy).A mean of (1.8±0.5) ×10(8)/kg autologous mononuclear cells were transplanted.The patients were followed up after transplantation. Results Severe bone marrow suppression occurred in all patients around day +7.Peripher al white blood cell count decreased to 0 in all patients at day +4.8±2.9, and platelet count decreased to less than 20×10(9)/L at day +9.0±2.6.Succ essful engraftment was achieved in 21 patients, but four died of infection at da y +17, +20, +31 and +67, respectively.Recovery of white blood cell (WBC) to 10×10(9)/L, absolute neutrophil count to 0.5×10(9)/L, platelet count to 20 ×10(9)/L occurred on 21±12, 26±13, and 27±10 days, respectively.During the follow up period, three patients relapsed at +5 months, +1.5 years, and +2 yea rs 10 months, respectively.One patient died of intracranial hemorrhage at +8 m onths.Thirteen patients had event-free survival for 2-12 years, with a mean o f 6.7±3.4 years.Conclusion Our preliminary data suggest that myeloablative therapy with low dose TBI (6.0 -9.0 Gy) combined with intensified chemotherapy followed by autologous periphe ral blood stem cell transplantation might be associated with favorable results i n children with refractory leukemia or solid tumors.     

白血病及重型再生障碍性贫血并发败血症40例临床分析

对白血病化疗后并发败血症35例及重型再生障碍性贫血并发败血症5例进行了分析,发现G杆菌占92％,原发感染灶中软组织较多,败血症时血清CRP明显升高,外周血中性粒细胞绝对值减少;应用普通抗生素组绿脓杆菌、大肠杆菌败血症多,治愈率41％,第三代头孢霉素组绿脓杆菌、克雷白杆菌败血症多,治愈率72％,两组病例治愈率差异显著(P相似文献