飞行员血液同型半胱氨酸与心血管疾病的相关性研究

目的 研究飞行员血液同型半胱氨酸(homocysteine,Hcy)水平变化,预测飞行员心血管事件的发生. 方法 将163例飞行员和60例男性健康地面工作人员(对照组)按年龄分别设21～30岁、31～40岁和41～50岁组;同时按飞行时间将飞行员分别设≤1000 h、1001～2000 h、2001～3000 h和3001～4000 h组;采用全自动生化分析仪测定Hcy浓度. 结果 飞行员组血液Hcy浓度为(9.86±4.45)μmol/L,对照组为(7.10±1.77)μmol/L.两组比较显示飞行员组血液Hcy明显高于对照组(t=4.67,P＜0.01);在不同年龄组血液Hcy测定中,对照组21～30岁组与41～50岁组差异显著(P＜0.05),飞行员不同年龄组之间差异均显著(P＜0.05或P＜0.01);在不同飞行时间血液Hcy测定中,1001～2000 h组、2001～3000 h组均与≤1000 h组差异显著(P＜0.01).同一年龄组中,飞行员血液Hcy浓度均高于对照组(t=3.893、6.221、3.193,P＜0.01). 结论 测定血液Hcy可预测飞行员心血管事件发生的危险性,应针对飞行员血液Hcy升高采取强有力的干预措施,从而有效预防飞行员冠心病的发生. Abstract： Objective To study the change of homocysteine (Hcy) concerntration in pilot's blood and to predict the occurrence of cardiovascular events of pilots. Methods One hundred and sixty-three pilots and 60 male health ground service personnel were selected as pilot and control groups and respectively divided by age as 21-30, 31-40 and 41-50 yrs sub-groups. Pilots were also grouped into ≤ 1000 h, 1001-2000 h, 2001-3000 h and 3001-4000 h sub-groups by flying hours. The concentration of Hcy were detected by using automatic biochemical analyzer. Results The Hcy concentration in pilot group was (9.86±4.45) μmol/L comparing to (7.10±1.77) μmol/L in control group and the difference between groups was significant (t=4.67, P＜0.01). For the Hcy change by age, significant differences were between sub-group 21-30 yrs and 41-50 yrs in control group (P＜0.05), and between each two sub-groups in pilot group (P＜0. 05 or P＜0. 01). For the Hcy detection by flying hours, sub-group 1001-2000 h and 2001-3000 h respectively showed significant difference to ≤ 1000 h sub-group (P ＜ 0.01). Between the same age sub-groups, the Hcy concentration in pilots is higher than that in control groups (t=3. 893, 6. 221, 3. 193, P＜0.01).Conclusions Detecting the Hcy concentration in blood can be used to predict the risk of cardiovascular events of pilot. Taking powerful intervention measure to restrict the elevation of Hcy level can effectively prevent coronary heart disease of pilot.