全文获取类型
收费全文 | 2152篇 |
免费 | 95篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 94篇 |
妇产科学 | 71篇 |
基础医学 | 374篇 |
口腔科学 | 31篇 |
临床医学 | 161篇 |
内科学 | 492篇 |
皮肤病学 | 62篇 |
神经病学 | 179篇 |
特种医学 | 142篇 |
外国民族医学 | 1篇 |
外科学 | 300篇 |
综合类 | 6篇 |
预防医学 | 121篇 |
眼科学 | 26篇 |
药学 | 96篇 |
肿瘤学 | 64篇 |
出版年
2021年 | 22篇 |
2020年 | 22篇 |
2019年 | 21篇 |
2018年 | 29篇 |
2017年 | 16篇 |
2016年 | 26篇 |
2015年 | 19篇 |
2014年 | 35篇 |
2013年 | 55篇 |
2012年 | 86篇 |
2011年 | 98篇 |
2010年 | 54篇 |
2009年 | 62篇 |
2008年 | 75篇 |
2007年 | 71篇 |
2006年 | 89篇 |
2005年 | 83篇 |
2004年 | 78篇 |
2003年 | 69篇 |
2002年 | 81篇 |
2001年 | 76篇 |
2000年 | 72篇 |
1999年 | 67篇 |
1998年 | 28篇 |
1997年 | 23篇 |
1996年 | 18篇 |
1995年 | 21篇 |
1992年 | 54篇 |
1991年 | 28篇 |
1990年 | 45篇 |
1989年 | 39篇 |
1988年 | 34篇 |
1987年 | 44篇 |
1986年 | 47篇 |
1985年 | 47篇 |
1984年 | 26篇 |
1983年 | 22篇 |
1982年 | 15篇 |
1981年 | 13篇 |
1979年 | 28篇 |
1978年 | 13篇 |
1977年 | 15篇 |
1975年 | 23篇 |
1974年 | 26篇 |
1973年 | 15篇 |
1971年 | 13篇 |
1969年 | 16篇 |
1968年 | 14篇 |
1966年 | 15篇 |
1961年 | 16篇 |
排序方式: 共有2247条查询结果,搜索用时 15 毫秒
1.
M. Knappik U. Börner T. Jelinek 《European journal of clinical microbiology & infectious diseases》2005,24(10):701-703
The study presented here was conducted to evaluate the performance of the newly available RIDASCREEN Set (R-Biopharm AG, Darmstadt,
Germany) for the detection of immunoglobulin G antibodies against Entamoeba histolytica. The sensitivity and specificity of this new enzyme-linked immunosorbent assay were evaluated using a panel of sera from
239 individuals. The assay was positive for 43 of 44 patients with invasive amebiasis, including all 18 patients with amebic
liver abscess, while it was negative for 190 of 195 adult controls who were either healthy individuals or patients with other
parasitic diseases. The kit was found to be highly specific (97.4%) and sensitive (97.7%) for detecting antibodies against
E. histolytica in humans. Although antibody titers in patients with amebic liver abscess tend to be higher on average than in patients with
invasive amebiasis, it is not possible to distinguish the two forms solely based on the results of this commercial test. 相似文献
2.
H Müller P Marck H Gips U B?rner O Otto H A Adams G Hempelmann 《Der Anaesthesist》1987,36(10):561-569
During opiate anesthesia (standardized dosage of fentanyl) for operation of cerebral aneurysms after subarachnoid hemorrhage, different hemodynamic, respiratory, metabolic, and endocrine parameters were determined before (1 in Fig. 1-4), after (6), and during consecutive stages of induced hypotension (systolic blood pressure 100 mmHg (2), 90 mmHg (3), 80 mmHg (4, 5) during an interval of 20 min), comparing two groups with different vasodilating drugs. In the first group (nimo/NNP in Figs. 2-4) a constant infusion of nimodipine was applied (1.2 micrograms/kg b.w. X min-1), while sodium nitroprusside (NNP) was added in small amounts as necessary to achieve the respective values of systolic blood pressure. In the second group (NNP in Figs. 2-4) induced hypotension was done with NNP alone (maximal dosage: 8 micrograms/kg X min-1). Each group consisted of 11 patients. Additional nimodipine (in the first group), a calcium antagonist commonly recommended for preventing vasospasm and consequent neurologic deficits after subarachnoid hemorrhage, not only reduced the need for NNP, a vasodilating drug with potential toxicity, by 70%-80% as compared to the second group (Table 1). In addition, the cardiovascular situation was more stable in patients with nimodipine infusion: rapid variations of blood pressure and heart rate as well as tachyphylaxis and rebound, typical for NNP-induced hypotension, were avoided. Nevertheless, comparing the hemodynamic data at fixed stages of hypotension, there were only minor differences between both groups (Fig. 2). Reduction of blood pressure was due to a decrease in vascular resistance and was accompanied by an increase in cardiac output.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
3.
4.
L Madacsy A Yasar T Tulassay A Körner J Kelemen M Hóbor M Miltényi 《Acta paediatrica (Oslo, Norway : 1992)》1994,83(4):414-417
Twenty-four-hour blood pressure and heart rate measurements were carried out in 14 newly diagnosed diabetics and in 28 diabetics with 5–13 years' duration of the disease; 8 healthy children were used as controls. Mean arterial blood pressure increased at night in 5, decreased slightly (less than 10%) in 5 and decreased markedly (more than 10%) in 18 diabetics with longer duration of the disease. The diurnal-nocturnal differences in heart rates were significantly lower in diabetics with relative "nocturnal hypertension" compared to the control group ( p < 0.05). A significant negative correlation was found between maximal arterial blood pressure during physical exercise and the diurnal-nocturnal differences in mean arterial blood pressure in diabetics ( r =−0.58; p < 0.02). In conclusion, we found elevated nocturnal blood pressure in a subgroup of children with longer duration of diabetes and without increased albumin excretion. However, longitudinal studies of blood pressure profiles are needed to identify the candidates for diabetic vasculopathy among diabetic children. 相似文献
5.
Ditmer Körner 《Mund-, Kiefer- und Gesichtschirurgie》2004,8(1):3-4
6.
B Lindblad G B?rner A Gotts?ter 《European journal of vascular and endovascular surgery》2005,30(4):346-352
OBJECTIVES: To investigate whether any variables in a health-screened population study were associated with later development of large abdominal aortic aneurysms (AAA). SETTING: Malm?, Southern Sweden. MATERIAL AND METHODS: Within the Malm? Preventive Study 22,444 men and 10,982 women were investigated between 1974 and 1991. The mean age at the health screening was 43.7 years. RESULTS: After a median follow-up of 21 years, 126 men and six women (p<0.001) had large AAA that were symptomatic or evaluated for operation (5 cm diameter or more) or had autopsy-verified ruptured AAA. The male group (mean age 47 years) was, because of difference in age (p<0.001) also compared with an age-matched control group. The male patients with AAA showed increased diastolic blood pressure (p<0.007) at the health screening. Smoking predicted the development of AAA (p<0.0001). No difference in forced vital capacity or BMI was seen. Those who were physically inactive (e.g. not walking or cycling to work) had an increased risk of developing AAA (p<0.001). Among the laboratory markers measured, the erythrocyte sedimentation rate did not differ (7.1+/-5.9 vs. 6.4+/-5.7), but cholesterol (6.3+/-1.12 vs. 5.8+/-1.0) (p<0.0001) and triglycerides (1.9+/-0.12 vs. 1.5+/-0.07) (p<0.001) were significantly elevated in these individuals who subsequently developing AAA. The inflammatory proteins alfa-1-antitrypsin, ceruloplasmin, orosmucoid, fibrinogen, and haptoglobulin were increased (p<0.001). CONCLUSION: Male gender, smoking, physical inactivity and cholesterol are significant factors associated with the development of AAA. 相似文献
7.
G Calaminus D Vesterling-H?rner J P B?kkerink H Gadner G Günther H J Haas H Jürgens C Teske U G?bel 《Klinische P?diatrie》1991,203(4):246-250
The cooperative therapy study MAKEI 83/86 included an examination of the prognostic value of the AFP in children and adolescents with extracranial non-testicular yolk sac tumors. The serum AFP values of 72 protocol- and follow-up-patients were documented at diagnosis and up to the ninth month of treatment. 32 of these patients had saccrococcygeal tumors, 27 had tumors of the ovary and 13 suffered from extragonadal germ cell-tumors. 4 children showed progressive disease under initial chemotherapy and 1 patient died of therapy, 10 of 72 patients relapsed. The AFP measurements were plotted on semilogarithmic charts. They were compared to the measurements of healthy children up to the age of 1 year. According to the development of the patients' AFP values compared to the reference curves the following classifications could be made: 1. Patients with a normal AFP-decrease id est 50% in less than or equal to 6 days during the 1st month of therapy: 48/72 patients 2. Patients with slow AFP-decrease: 17/72 patients 3. Patients with transient AFP-decrease: 5/72 patients 4. Patients with no AFP-decrease: 2/72 patients According to Kaplan-Meier life table analysis, patients with a normal AFP-decrease had an event-free survival of 89% +/- 4%, whereas all other patients showed an event-free survival of 63% +/- 10% (p less than 0.05). Regarding primary therapy id est tumor resection or preoperative chemotherapy an equal distribution of the patients among those with a normal and slow AFP-decrease was observed.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
8.
The number of colony-forming cells (CFC) in the peripheral blood (PB) of 43 volunteers was examined using a semisolid clonogenic
culture assay. In all, 22 male (age 21–39 years) and 21 female individuals (age 21–39 years) were tested, ten of each group
twice to examine the intraindividual variability of colony-forming cells in PB. A statistically significant sex difference
in the number of CFC, erythroblastic colonies (BFU-E), and granulocyte/macrophage colonies (CFU-GM) in PB was detected in
favor of male individuals. No significant difference between female and male PB was found for the number of CFU-GEMM. The
intraindividual variability of CFC and BFU-E was significantly higher in female donors. These results support previous reports
by others on a potential influence of sex steroids on hematopoiesis.
Received: 8 November 1996 / Accepted: 4 April 1997 相似文献
9.
10.