全文获取类型
收费全文 | 1013篇 |
免费 | 70篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 69篇 |
妇产科学 | 14篇 |
基础医学 | 135篇 |
口腔科学 | 20篇 |
临床医学 | 62篇 |
内科学 | 146篇 |
皮肤病学 | 11篇 |
神经病学 | 413篇 |
特种医学 | 26篇 |
外科学 | 58篇 |
综合类 | 5篇 |
预防医学 | 45篇 |
眼科学 | 6篇 |
药学 | 47篇 |
肿瘤学 | 22篇 |
出版年
2023年 | 14篇 |
2022年 | 15篇 |
2021年 | 12篇 |
2020年 | 6篇 |
2019年 | 16篇 |
2018年 | 23篇 |
2017年 | 12篇 |
2016年 | 27篇 |
2015年 | 16篇 |
2014年 | 27篇 |
2013年 | 32篇 |
2012年 | 58篇 |
2011年 | 50篇 |
2010年 | 34篇 |
2009年 | 33篇 |
2008年 | 44篇 |
2007年 | 39篇 |
2006年 | 47篇 |
2005年 | 34篇 |
2004年 | 34篇 |
2003年 | 48篇 |
2002年 | 39篇 |
2001年 | 30篇 |
2000年 | 52篇 |
1999年 | 44篇 |
1998年 | 5篇 |
1997年 | 14篇 |
1996年 | 14篇 |
1995年 | 12篇 |
1994年 | 12篇 |
1993年 | 10篇 |
1992年 | 15篇 |
1991年 | 21篇 |
1990年 | 18篇 |
1989年 | 16篇 |
1988年 | 14篇 |
1987年 | 19篇 |
1986年 | 14篇 |
1985年 | 12篇 |
1984年 | 14篇 |
1983年 | 13篇 |
1982年 | 10篇 |
1981年 | 6篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1975年 | 4篇 |
1974年 | 5篇 |
1973年 | 4篇 |
1967年 | 3篇 |
1966年 | 3篇 |
排序方式: 共有1086条查询结果,搜索用时 15 毫秒
1.
C Schmitt J Brachmann W Saggau T Beyer B Waldecker K Scharowski T Hilbel M Montero B Offner W Sch?ls 《Zeitschrift für Kardiologie》1991,80(11):665-672
In 41 patients with recurrent sustained ventricular tachycardia and/or ventricular fibrillation an integrated pacemaker-defibrillator-system (PCD, Medtronic, model 7216 A or 7217 B) was implanted. In 21 out of 24 (88%) patients a new transvenous implantation technique in combination with a subcutaneous patch electrode was used. The implanted devices comprise antibradycardiac pacemaker functions, two different forms of antitachycardiac pacemaker functions (ramp and burst pacing), and internal cardioversion or defibrillation capabilities. During a mean follow-up of 8 months 147 episodes of ventricular tachycardia were detected, 131 of them were terminated successfully by antitachycardiac pacing; in 13 episodes internal cardioversion was applied to revert ventricular tachycardia. Twenty-seven episodes of ventricular fibrillation or rapid ventricular tachycardia (greater than 200/min) were detected and successfully terminated by internal defibrillation. In six patients with intermittent rapid atrial fibrillation, change of antiarrhythmic therapy was required to avoid activation of the device. The new integrated pacemaker-defibrillator systems improve therapy in patients with life-threatening tachyarrhythmias by reducing the number of internal cardioversions/defibrillations; the non-thoracotomy approach reduces the post operative risk. 相似文献
2.
S. T. F. M. Frequin F. J. M. Gabreë ls A. A. W. M. Gabreë ls-Festen E. M. G. Joosten 《Clinical neurology and neurosurgery》1991,93(4):323-326
A girl of 14 year is presented with a distal spinal muscular atrophy (SMA) with autosomal recessive inheritance. The technical findings are in agreement with the diagnosis. Light microscopical examination of sural nerve biopsy, including teased fiber studies and morphometry, showed no abnormalities. Electron microscopical investigation however demonstrated axonal pathology. The question arises if distal SMA is a distal axonopathy mainly of motor nerves, but to some extent also of sensory nerves. 相似文献
3.
4.
A A Gabre?ls-Festen F J Gabre?ls E M Joosten H M Vingerhoets W O Renier 《Neuropediatrics》1992,23(3):138-143
Four children, index cases of families in which autosomal dominant neuropathy with liability to pressure palsies (HNPP) was diagnosed, are presented. Only one child was admitted for evaluation of an acute peroneal palsy, three presented with other symptoms. Polyneuropathy was diagnosed in all four children, in one of their parents and in some sibs. On inquiry, one child and several members of the four families had experienced transient palsies before. Morphological studies of the sural nerves showed frequently large tomacula and a neuropathic process of segmental de- and remyelination, and axonal degeneration. Attention is drawn to the atypical presentation without pressure palsies of HNPP. 相似文献
5.
G P Gerrits A A Haagen R A De Abreu L A Monnens F J Gabre?ls F J Trijbels A L Theeuwes J M van Baal 《Clinical chemistry》1988,34(7):1439-1442
Disturbances in the metabolism of purines and pyrimidines in neurologically affected patients can be reflected by aberrant concentrations of nucleosides and nucleobases in cerebrospinal fluid (CSF). However, normal values, especially for children at different ages, are lacking. We collected 1000 specimens of CSF from subjects ranging in age from newborn to 18 years, who were undergoing a diagnostic lumbar puncture for several clinical indications. Of these, 78 samples could be used retrospectively as a reference according to our criteria. The analyses were performed with a modified HPLC procedure. None of the substances shows age-dependency except uridine and uric acid. Uridine increases with age, and uric acid increases with age in boys older than 12 years. 相似文献
6.
The role of oxygen supply in islet transplantation. 总被引:1,自引:0,他引:1
7.
Spatial Learning Deficits in Mice with a Targeted Glucocorticoid Receptor Gene Disruption 总被引:5,自引:0,他引:5
Melly S. Oitzl E. Ron de Kloet Marian Joëls Wolfgang Schmid Timothy J. Cole 《The European journal of neuroscience》1997,9(11):2284-2296
Previous studies in rats using the Morris water maze suggested that the processing of spatial information is modulated by corticosteroid hormones through mineralocorticoid and glucocorticoid receptors in the hippocampus. Mineralocorticoid receptors appear to be involved in the modulation of explorative behaviour, while additional activation of glucocorticoid receptors facilitates the storage of information. In the present study we used the water maze task to examine spatial learning and memory in mice homozygous and heterozygous for a targeted disruption of the glucocorticoid receptor gene. Compared with wild-type controls, homozygous and heterozygous mice were impaired in the processing of spatial but not visual information. Homozygous mutants performed variably during training, without specific platform-directed search strategies. The spatial learning disability was partly compensated for by increased motor activity. The deficits were indicative of a dysfunction of glucocorticoid receptors as well as of mineralocorticoid receptors. Although the heterozygous mice performed similarly to wild-type mice with respect to latency to find the platform, their strategy was more similar to that of the homozygous mice. Glucocorticoid receptor-related long-term spatial memory was impaired. The increased behavioural reactivity of the heterozygous mice in the open field points to a more prominent mineralocorticoid receptor-mediated function. The findings indicate that (i) the glucocorticoid receptor is of critical importance for the control of spatial behavioural functions, and (ii) mineralocorticoid receptor-mediated effects on this behaviour require interaction with functional glucocorticoid receptors. Until the development of site-specific, inducible glucocorticoid receptor mutants, glucocorticoid receptor-knockout mice present the only animal model for the study of corticosteroid-mediated effects in the complete absence of a functional receptor. 相似文献
8.
J A van Son W N van Asten H J van Lier O Dani?ls S H Skotnicki L K Lacquet 《The Journal of thoracic and cardiovascular surgery》1990,100(6):817-829
The reported relatively high incidence of early restenosis at the coarctation repair site with subclavian flap angioplasty, especially in infants less than 3 months of age, prompted a physiologically oriented analysis of relief of obstruction from coarctation after subclavian flap angioplasty versus resection and end-to-end anastomosis in infancy. Twenty-one patients who had undergone repair of coarctation in infancy by either subclavian flap angioplasty (nine patients) (median age 8 years) or resection and end-to-end anastomosis (12 patients) (median age 8 years) were evaluated by Doppler spectrum analysis of the blood flow velocities in the femoral artery at rest and during reactive hyperemia. The median resting right upper to lower limb systolic pressure difference (with interquartile range) was similar in the angioplasty, resection and anastomosis, and control groups: -5 mm Hg (18 mm Hg), 0 mm Hg (12 mm Hg), and -2.5 mm Hg (10 mm Hg), respectively. Also, similar resting values for the maximum frequency of the advancing curve and the pulsatility and resistance indices were measured in the three groups. During reactive hyperemia of the leg, however, a significant hemodynamic obstruction across the repair site became clinically manifest in the angioplasty group only, as documented by a lower pulsatility index in comparison with the control group (p = 0.01, Mann-Whitney U test). Comparison of the hemodynamic results between the angioplasty and resection and anastomosis groups in subdivisions of infants operated on at an age of less or greater than 3 months, both at rest and during reactive hyperemia, showed, already at rest, a significantly lower value for the pulsatility index in the former angioplasty subdivision (p = 0.05, Student's t test), indicating a significant resistance at the coarctation repair site in the angioplasty patients operated on before the third month of life. A disadvantage of angioplasty (compared with resection and anastomosis) was noted when angioplasty was performed before the third month of life, and an unequivocal lack of advantage was noted when performed beyond that period regarding relief of obstruction from coarctation. In addition, a definite potential for adverse long-term effects on the hemodynamics of the left upper limb after subclavian flap angioplasty in infancy has been documented. For these reasons we prefer to perform resection and end-to-end anastomosis for repair of coarctation in infancy. 相似文献
9.
Mental retardation and parental occupation: a study on the applicability of job exposure matrices. 总被引:5,自引:4,他引:1 下载免费PDF全文
In a case-referent study on mental retardation and parental occupation, the applicability of job exposure matrices for the identification of risk factors was evaluated. The parents of 306 mentally retarded children (cases) and 322 referents were interviewed about their occupational activities in the pregnancy period. Detailed occupational histories were obtained that were compared with exposures generated by two different job exposure matrices. The agreement between interview and matrices was low: the sensitivity ranged from 17.9% to 32.4% and the percentages of false positive exposures from 66.7% to 96.0%. By means of the interview, significantly increased odds ratios (ORs) were found for exposure of the mother in late pregnancy to radiation (OR = 9.3), mercury (OR = 8.7), organic solvents (OR = 1.7), hair cosmetics and dyes (OR = 3.7), paint (OR = 2.7), hexachlorophene/phenylphenol (OR = 3.1), antibiotics (OR = 2.9), and dust (OR = 2.2) and for working with copying machines (OR = 3.0) or in occupations with poor climatological circumstances and permanent contact with people. The last was confirmed by the British matrix (OR = 1.7). Otherwise, most of the mentioned associations were missed by the job exposure matrices. Therefore, these matrices were not considered to be applicable in this particular study, nor in most other reproductive epidemiological studies in view of their general properties and limitations. 相似文献
10.
Q H Leyten F J Gabre?ls W O Renier K Renkawek H J ter Laak R A Mullaart 《Neuropediatrics》1992,23(6):316-320
From four Dutch families six patients, who have congenital muscular dystrophy, involvement of the central nervous system and of the eyes, or the so-called "muscle, eye and brain disease" (MEB-D), are reported. Two patients are still alive, in four autopsy could be performed. The clinical and morphological data of our patients are compared to those described in recent literature. The progression of the disease was rapid in five of our six patients. Our study supports the idea that within the MEB-D syndrome there are at least two different types of clinical expression, one with a rapid progression as described by Dobyns et al 1989 (9) and one with a slower progression as described in most patients of Santavuori et al 1989 (23). The study also confirms the autosomal recessive mode of inheritance of MEB-D. 相似文献