收费全文 | 26361篇 |
免费 | 1232篇 |
国内免费 | 174篇 |
耳鼻咽喉 | 168篇 |
儿科学 | 361篇 |
妇产科学 | 436篇 |
基础医学 | 3575篇 |
口腔科学 | 572篇 |
临床医学 | 1552篇 |
内科学 | 6780篇 |
皮肤病学 | 420篇 |
神经病学 | 2394篇 |
特种医学 | 1041篇 |
外科学 | 4494篇 |
综合类 | 106篇 |
一般理论 | 1篇 |
预防医学 | 707篇 |
眼科学 | 588篇 |
药学 | 1905篇 |
中国医学 | 98篇 |
肿瘤学 | 2569篇 |
2022年 | 178篇 |
2021年 | 355篇 |
2020年 | 274篇 |
2019年 | 303篇 |
2018年 | 412篇 |
2017年 | 323篇 |
2016年 | 412篇 |
2015年 | 429篇 |
2014年 | 592篇 |
2013年 | 746篇 |
2012年 | 1168篇 |
2011年 | 1307篇 |
2010年 | 737篇 |
2009年 | 642篇 |
2008年 | 1210篇 |
2007年 | 1248篇 |
2006年 | 1200篇 |
2005年 | 1296篇 |
2004年 | 1357篇 |
2003年 | 1339篇 |
2002年 | 1373篇 |
2001年 | 904篇 |
2000年 | 921篇 |
1999年 | 869篇 |
1998年 | 418篇 |
1997年 | 339篇 |
1996年 | 282篇 |
1995年 | 254篇 |
1994年 | 272篇 |
1993年 | 231篇 |
1992年 | 598篇 |
1991年 | 516篇 |
1990年 | 522篇 |
1989年 | 526篇 |
1988年 | 478篇 |
1987年 | 395篇 |
1986年 | 384篇 |
1985年 | 377篇 |
1984年 | 278篇 |
1983年 | 221篇 |
1982年 | 132篇 |
1981年 | 114篇 |
1980年 | 100篇 |
1979年 | 190篇 |
1978年 | 150篇 |
1977年 | 129篇 |
1972年 | 102篇 |
1971年 | 105篇 |
1968年 | 101篇 |
1967年 | 98篇 |
Research design and methods: This multicenter, open-label, single-group, prospective interventional study evaluated changes in total gait-related scores of the Part II/III Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) and Freezing of Gait Questionnaire (FOG-Q) in 31 Parkinson’s disease patients treated with istradefylline. Gait analysis by portable gait rhythmogram was performed.
Results: MDS-UPDRS Part III gait-related total scores significantly decreased at Weeks 4–12 from baseline with significant improvements in gait, freezing of gait, and postural stability. Significant decreases in MDS-UPDRS Part II total scores and individual item scores at Week 12 indicated improved daily living activities. At Week 12, there were significant improvements in FOG-Q, new FOG-Q, and overall movement per 48 h measured by portable gait rhythmogram. Adverse events occurred in 7/31 patients.
Conclusions: Istradefylline improved gait disorders in Parkinson’s disease patients complicated with freezing of gait, improving their quality of life. No unexpected adverse drug reactions were identified.
Trial registration: UMIN-CTR (UMIN000020288). 相似文献
Purpose
Suppression of respiratory movement of the liver would be desirable for high-precision radiation therapy for liver tumors. We aimed to investigate the effect of our original device-free compressed shell fixation method and breathing instruction on suppression of respiratory movement. The characteristics of liver motion based on the movement of a fiducial marker were also analyzed.Methods and Materials
First, respiratory amplitudes of the liver with the device-free compressed shell were analyzed from the data of 146 patients. The effect of this shell fixing method on liver movement was evaluated. Second, as another cohort study with 166 patients, interfractional internal motion of the liver for patients fixed in the shell was calculated using the fiducial marker coordinate data of images for position setting before daily irradiation. Third, in another 12 patients, intrafractional internal motion was calculated from the fiducial marker coordinate data using x-ray images before and after irradiation.Results
The median respiratory movement without the shell, after fixing with the shell, and after instructing on the breathing method with the shell was 14.2 (interquartile range, 10.7-19.8), 11.5 (8.6-17.5), and 10.4 mm (7.3-15.8), respectively. Systematic and random errors of interfractional internal motion were all ≤2 mm in the left-right and anteroposterior directions and 3.7 and 3.0 mm, respectively, in the craniocaudal direction. Systematic and random errors of intrafractional internal motion were all ≤1.3 mm in the left-right and anteroposterior directions and 0.8 and 2.4 mm, respectively, in the craniocaudal direction.Conclusions
The device-free compressed shell fixation method was effective in suppressing the respiratory movement of the liver. Irradiation position matching using the fiducial marker can correct the interfractional internal motion on each day, which would contribute to the reduction of the margin to be given around the target. 相似文献Objective
This study assessed the association between the timing of first epinephrine administration (EA) and the neurological outcomes following out-of-hospital cardiac arrests (OHCAs) with both initial shockable and non-shockable rhythms.Methods
This was a post-hoc analysis of a multicenter prospective cohort study (SOS-KANTO 2012), which registered OHCA patients in the Kanto region of Japan from January 2012 to March 2013. We included consecutive adult OHCA patients who received epinephrine. The primary result included 1-month favorable neurological outcomes defined as cerebral performance category (CPC) 1 or 2. Secondary results included 1-month survival and return of spontaneous circulation (ROSC) after arrival at the hospital. Multivariable logistic regression analysis determined the association between delay per minute of the time from call to first EA in both pre- or in-hospital settings and outcomes.Results
Of the 16,452 patients, 9344 were eligible for our analyses. In univariable analysis, the delay in EA was associated with decreased favorable neurological outcomes only when the initial rhythm was a non-shockable rhythm. In multivariable analyses, delay in EA was associated with decreased ROSC (adjusted odds ratio [OR] for one minute delay, 0.97; 95% confidence interval [CI], 0.96–0.98) and 1-month survival (adjusted OR, 0.95; 95% CI, 0.92–0.97) when the initial rhythm was a non-shockable rhythm, whereas during a shockable rhythm, delay in EA was not associated with decreased ROSC and 1-month survival.Conclusions
While assessing the effectiveness of epinephrine for OHCA, we should consider the time-limited effects of epinephrine. Additionally, consideration of early EA based on the pathophysiology is needed. 相似文献![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)