全文获取类型
收费全文 | 4931篇 |
免费 | 469篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 41篇 |
儿科学 | 149篇 |
妇产科学 | 114篇 |
基础医学 | 506篇 |
口腔科学 | 85篇 |
临床医学 | 560篇 |
内科学 | 1128篇 |
皮肤病学 | 59篇 |
神经病学 | 385篇 |
特种医学 | 257篇 |
外科学 | 956篇 |
综合类 | 158篇 |
一般理论 | 5篇 |
预防医学 | 549篇 |
眼科学 | 85篇 |
药学 | 211篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 160篇 |
出版年
2021年 | 50篇 |
2020年 | 41篇 |
2019年 | 73篇 |
2018年 | 89篇 |
2017年 | 36篇 |
2016年 | 50篇 |
2015年 | 63篇 |
2014年 | 98篇 |
2013年 | 131篇 |
2012年 | 149篇 |
2011年 | 186篇 |
2010年 | 114篇 |
2009年 | 119篇 |
2008年 | 184篇 |
2007年 | 199篇 |
2006年 | 218篇 |
2005年 | 217篇 |
2004年 | 215篇 |
2003年 | 201篇 |
2002年 | 199篇 |
2001年 | 191篇 |
2000年 | 190篇 |
1999年 | 143篇 |
1998年 | 85篇 |
1997年 | 85篇 |
1996年 | 82篇 |
1995年 | 77篇 |
1994年 | 65篇 |
1993年 | 81篇 |
1992年 | 155篇 |
1991年 | 135篇 |
1990年 | 102篇 |
1989年 | 108篇 |
1988年 | 117篇 |
1987年 | 108篇 |
1986年 | 104篇 |
1985年 | 83篇 |
1984年 | 80篇 |
1983年 | 53篇 |
1982年 | 55篇 |
1981年 | 46篇 |
1980年 | 40篇 |
1979年 | 50篇 |
1978年 | 45篇 |
1977年 | 48篇 |
1976年 | 50篇 |
1975年 | 50篇 |
1974年 | 45篇 |
1973年 | 39篇 |
1972年 | 45篇 |
排序方式: 共有5410条查询结果,搜索用时 31 毫秒
1.
2.
Mohammad K. Jamal M.D. Eric J. DeMaria M.D. Jason M. Johnson D.O. Brennan J. Carmody M.D. Luke G. Wolfe M.S. John M. Kellum M.D. Jill G. Meador R.N. 《Surgery for obesity and related diseases》2006,2(2):417-127
BACKGROUND: Preoperative dietary counseling (PDC) before bariatric surgery is mandated by a growing number of insurance payers. Their claim is that PDC improves outcomes and postoperative compliance. We compared outcomes of GBP patients undergoing a mandatory 13 weeks of PDC (n = 72) to a contemporaneous group of patients with no such requirement (no-PDC; n = 252) who underwent operation between January 2000 and December 2002. METHODS: The PDC and no-PDC groups were characterized by similar male:female ratios (1:4 vs 1:4.6), mean age (42 years), mean body weight (324 lb vs 309 lb), and mean body mass index (BMI) (52 kg/m2 vs 50 kg/m2). The PDC group had a higher incidence of obstructive sleep apnea compared with the no-PDC group (41% vs 28%; P < .04) but otherwise the two groups had similar incidences of obesity-related comorbidities. The presurgery dropout rate was 50% higher in the PDC group than in the no-PDC group (28% vs 19%; P < .05). RESULTS: At 1 year follow-up, the no-PDC patients had a statistically greater percentage excess weight loss (67% vs 60%; P < .0001), lower BMI (32 vs 35; P < .015), and lower body weight (197 vs 218; P < .01). Resolution of major comorbidities, complication rates, 30-day postoperative mortality, and postoperative compliance with follow-up were similar in the two groups. CONCLUSIONS: The data demonstrate that insurance-mandated PDC is an obstacle to patient access for surgical treatment of severe obesity and has no impact on weight loss outcome or postsurgical compliance. PDC should be abandoned by the insurance industry. 相似文献
3.
4.
R. A. Wolfe F. B. LaPorte A. M. Rodgers E. C. Roys G. Fant A. B. Leichtman 《American journal of transplantation》2007,7(S1):1404-1411
Turndowns of offers of deceased donor kidneys for transplantation can contribute to inefficiencies in the organ distribution system and inequality in access to donated organs. Match run data were obtained for 4967 'good' kidneys placed and transplanted in 2005 after fewer than 50 offers. These kidneys were not recovered from donation after cardiac death or expanded criteria donors, or from donors with a history of substance abuse. On average, these good kidneys were not accepted until after seven offers to candidates and after offers to 2.4 programs. Models for the likelihood of acceptance found several donor and candidate characteristics to be significantly related to acceptance rates (p < 0.05). After accounting for these variables, there remained 2- to 3-fold differences among transplant programs in acceptance rates. These models could be used to identify kidney transplant centers with exceptional acceptance practices. Several strategies might be employed to increase acceptance rates for good organs. 相似文献
5.
Safety and efficacy of bariatric surgery: Longitudinal Assessment of Bariatric Surgery 总被引:3,自引:0,他引:3
Steven H. Belle Ph.D. M.Sc.Hyg. Paul D. Berk M.D. Anita P. Courcoulas M.D. M.P.H. F.A.C.S. David R. Flum M.D. M.P.H. F.A.C.S. Carolyn W. Miles Ph.D. James E. Mitchell M.D. Walter J. Pories M.D. F.A.C.S. Bruce M. Wolfe M.D. F.A.C.S. Susan Z. Yanovski M.D. Longitudinal Assessment of Bariatric Surgery Consortium Writing Group 《Surgery for obesity and related diseases》2007,3(2):116-126
6.
7.
8.
X J Zhang K R Kunkel F Jahoor R R Wolfe 《JPEN. Journal of parenteral and enteral nutrition》1991,15(4):394-399
We have investigated the role of basal insulin concentration on leucine kinetics (determined by means of 1-[13C]leucine) and energy metabolism (determined by indirect calorimetry) in eight septic patients by reducing insulin (and glucagon) secretion by somatostatin infusion. Basal glucagon concentration was elevated (744 +/- 381 pg/mL), and insulin concentration was normal (10 +/- 4 microU/mL). Basal resting energy expenditure (REE) was 151 +/- 8% that of predicted basal energy expenditure, and leucine appearance (Ra), oxidation, and nonoxidative disposal rates were all elevated above the normal ranges. Somatostatin infusion reduced insulin concentration by 52% and glucagon concentration by 64%. This resulted in a significant increase in the rate of leucine oxidation from 0.96 +/- 0.08 to 1.18 +/- 0.14 mumol/kg/min (p less than 0.01), and nonoxidative leucine disposal decreased from 2.95 +/- 0.18 to 2.67 +/- 0.17 mumol/kg/min (p less than 0.01). Somatostatin infusion also caused significant increases in REE and fat oxidation from 1310 +/- 100 to 1505 +/- 128 kcal/m2/day (p less than 0.05) and from 1.72 +/- 0.24 to 2.41 +/- 0.41 mg/kg/min, respectively, and a slight decrease of carbohydrate oxidation from 1.51 +/- 0.49 to 1.31 +/- 0.49 mg/kg/min. These metabolic responses can be attributed to the reduction in insulin concentration, because they are in the opposite direction of changes that would occur as a consequence of a reduction in glucagon concentration. We conclude that the basal insulin plays an important role in attenuating net protein loss and energy expenditure. 相似文献
9.
Stephen Sawada Otto Muzik Rob S. B. Beanlands Edwin Wolfe Gary D. Hutchins Markus Schwaiger 《Journal of nuclear cardiology》1995,2(5):413-422
Background
Experimental studies have shown that positron emission tomography (PET) with 13N-labeled ammonia provides accurate quantification of regional myocardial blood flow (MBF) under rest and stress conditions. To establish the clinical utility of this method, the interobserver variability and the temporal variability of serial measurements of blood flow and coronary flow reserve (CFR) must be known. This study investigated the interobserver and temporal reproducibility of 13N-labeled PET for measurement of MBF and CFR. 相似文献10.
De Leo V; Morgante G; Lanzetta D; D'Antona D; Bertieri RS 《Human reproduction (Oxford, England)》1997,12(2):357-360
We report the results of administration of danazol after suspension of
gonadotrophin-releasing hormone analogue (GnRHa) therapy for uterine
myomas. A total of 21 women with uterine myomas was treated with 100 mg
danazol for 6 months after GnRHa therapy. Uterine volume and endocrine
status were monitored monthly by ultrasound and assay of plasma
gonadotrophins, oestradiol and progesterone. The results show a rebound of
uterine volume about 30% less than in controls at the end of danazol
therapy. Menstrual cyclicity returned after 65 +/- 3 days in 16 subjects
and five patients remained amenorrhoeic. Hormone assays confirmed renewed
ovarian function in the women whose menstrual periods returned. Bone
mineral content was substantially reduced during GnRHa treatment but
improved significantly during danazol therapy even in the women who
remained amenorrhoeic. These results show the utility of danazol in
prolonging the therapeutic effects of GnRHa. The mechanism by which danazol
inhibits rebound of uterine volume may be due to its antiprogesterone
effects on uterine myomas.
相似文献