收费全文 | 20074篇 |
免费 | 1252篇 |
国内免费 | 62篇 |
耳鼻咽喉 | 498篇 |
儿科学 | 605篇 |
妇产科学 | 447篇 |
基础医学 | 3255篇 |
口腔科学 | 478篇 |
临床医学 | 1920篇 |
内科学 | 3346篇 |
皮肤病学 | 453篇 |
神经病学 | 1969篇 |
特种医学 | 1004篇 |
外科学 | 2830篇 |
综合类 | 317篇 |
一般理论 | 2篇 |
预防医学 | 1208篇 |
眼科学 | 698篇 |
药学 | 1342篇 |
中国医学 | 21篇 |
肿瘤学 | 995篇 |
2022年 | 102篇 |
2021年 | 240篇 |
2020年 | 158篇 |
2019年 | 279篇 |
2018年 | 339篇 |
2017年 | 263篇 |
2016年 | 368篇 |
2015年 | 386篇 |
2014年 | 463篇 |
2013年 | 607篇 |
2012年 | 1069篇 |
2011年 | 1010篇 |
2010年 | 641篇 |
2009年 | 652篇 |
2008年 | 918篇 |
2007年 | 1005篇 |
2006年 | 1076篇 |
2005年 | 1059篇 |
2004年 | 991篇 |
2003年 | 872篇 |
2002年 | 920篇 |
2001年 | 502篇 |
2000年 | 456篇 |
1999年 | 435篇 |
1998年 | 276篇 |
1997年 | 231篇 |
1996年 | 224篇 |
1995年 | 174篇 |
1994年 | 161篇 |
1993年 | 149篇 |
1992年 | 247篇 |
1991年 | 243篇 |
1990年 | 240篇 |
1989年 | 243篇 |
1988年 | 236篇 |
1987年 | 195篇 |
1986年 | 190篇 |
1985年 | 209篇 |
1984年 | 187篇 |
1983年 | 135篇 |
1982年 | 123篇 |
1981年 | 123篇 |
1979年 | 156篇 |
1978年 | 123篇 |
1977年 | 126篇 |
1976年 | 111篇 |
1975年 | 123篇 |
1974年 | 125篇 |
1973年 | 105篇 |
1972年 | 111篇 |
Purpose
Endovascular treatment with mechanical thrombectomy devices demonstrated high recanalization rates but functional outcome did not correlate with high rates of recanalization obtained. Patient selection prior to the endovascular treatment is very important in the final outcome of the patient. The primary aim of our study was to evaluate the prognostic value of posterior circulation Alberta Stroke Program Early CT Score (pc-ASPECTS) and Pons-Midbrain Index (PMI) scores in patients with Basilar Artery Occlusion (BAO) treated with successful angiographic recanalization after mechanical thrombectomy.Methods
Retrospective single-center study including 18 patients between 2008 and 2013 who had acute basilar artery occlusion managed with endovascular treatment within 24 hours from symptoms onset and with successful angiographic recanalization. The patients were initially classified into two groups according to clinical outcome and mortality at 90 days. For analysis we also divided patients into groups based on pc-ASPECTS (≥8vs.< 8) and PMI (≥3vs.< 3) on non-contrast CT (NCCT) and CT Angiography Source Images (CTASI). Imaging data were correlated to clinical outcome and mortality rate.Results
CTASI pc-ASPECTS, dichotomized at < 8 versus≥8, was associated with a favorable outcome (RR: 2.6; 95% CI: 1.3-5.2) and a reduced risk of death (RR: 6.5: 95% CI: 7.8-23.3). All patients that survived and were functionally independent had pc-ASPECTS score≥8. None of the 5 patients with CTASI pc-ASPECTS score less than 8 survived.Conclusion
PC-ASPECTS on CTASI is helpful for predicting functional outcome after BAO recanalization with endovascular treatment. These results should be validated in a randomized controlled trial in order to decide whether or not to treat a patient with BAO. 相似文献The metabolism of the pyrethroids deltamethrin (DLM), cis-permethrin (CPM) and trans-permethrin (TPM) was studied in human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes.
DLM, CPM and TPM were metabolised by human CYP2B6 and CYP2C19, with the highest apparent intrinsic clearance (CLint) values for pyrethroid metabolism being observed with CYP2C19. Other CYP enzymes contributing to the metabolism of one or more of the three pyrethroids were CYP1A2, CYP2C8, CYP2C9*1, CYP2D6*1, CYP3A4 and CYP3A5. None of the pyrethroids were metabolised by CYP2A6, CYP2E1, CYP3A7 or CYP4A11.
DLM, CPM and TPM were metabolised by both human CES1 and CES2 enzymes.
Apparent CLint values for pyrethroid metabolism by CYP and CES enzymes were scaled to per gram of adult human liver using abundance values for microsomal CYP enzymes and for CES enzymes in liver microsomes and cytosol. TPM had the highest and CPM the lowest apparent CLint values for total metabolism (CYP and CES enzymes) per gram of adult human liver.
Due to their higher abundance, all three pyrethroids were extensively metabolised by CES enzymes in adult human liver, with CYP enzymes only accounting for 2%, 10% and 1% of total metabolism for DLM, CPM and TPM, respectively.