餐后高血糖是卒中的危险因素吗？

卒中的危险因素包括不可纠正因素（年龄、性别、种族、遗传因素等）和可纠正的危险因素（吸烟、饮酒、肥胖、高血压、高血脂、高血糖等）。由于高血糖是卒中重要的可纠正危险因素之一,深入了解血糖异常与卒中的关系,切实做好血糖管理,对于卒中的预防有重要意义。     

Comparative analysis of the prion protein gene sequences in African lion

The prion protein gene of African lion (Panthera Leo) was first cloned and polymorphisms screened. The results suggest that the prion protein gene of eight African lions is highly homogenous. The amino acid sequences of the prion protein (PrP) of all samples tested were identical. Four single nucleotide polymorphisms (C42T, C81A, C420T, T600C) in the prion protein gene (Prnp) of African lion were found, but no amino acid substitutions. Sequence analysis showed that the higher homology is observed to felis catus AF003087 (96.7%) and to sheep number M31313.1 (96.2%) Genbank accessed. With respect to all the mammalian prion protein sequences compared, the African lion prion protein sequence has three amino acid substitutions. The homology might in turn affect the potential intermolecular interactions critical for cross species transmission of prion disease     

多层螺旋CT薄层扫描MPR重建对周围型小肺癌的诊断价值

目的:探讨多层螺旋CT薄层扫描及MPR重建对周围型小肺癌的征象显示率及诊断价值.方法:对经手术病理证实的15例周围型小肺癌进行了多层螺旋CT常规扫描,并对病灶区域薄层重建及MPR多层面重建观察,8例行动态增强扫描.结果:薄层MPR重建对周围型小肺癌的征象显示率明显高于常规扫描,具体是:薄层MPR显示分叶征12例,常规扫描显示10例(12/10)、薄层MPR显示空泡征3例,常规扫描2例(3/2)、薄层MPR显示小结节堆砌征5例,常规扫描3例(5/3)、薄层MPR显示支气管通气征4例,常规扫描显示1例(4/1)、薄层MPR显示毛刺征9例,常规扫描显示5例(9/5)、薄层MPR显示胸膜凹陷征5例,常规扫描发现2例(5/2).结论:多层螺旋CT薄层扫描及MPR重建对周围型小肺癌的征象显示率高,可以弥补横断位图像显示肿瘤征象不全面的缺点,在诊断及鉴别诊断方面具有较高的临床应用价值.     

急性高危脑梗死患者规范诊治1例报道

1病例介绍 患者,男性,67岁,因“突发右侧肢体麻木无力2 h”于2012年5月25日15∶53收入本院神经内科。患者于入院前2 h（当天14∶00时）看电视时突然出现右侧肢体麻木无力,右手控制遥控器不灵活,右下肢跛行,可独立行走,无意识障碍、口齿不清、口角歪斜,无头痛、头晕;1h后症状无明显缓解,来我院急诊科就诊,当时测血压150/90 mmHg,急查颅脑计算机断层扫描（computed tomography,CT）“未见明显异常”（图1）。     

控制高血糖防治卒中的临床研究

<正>血糖增高可分成糖尿病和糖尿病前期两大类,糖尿病前期包括空腹血糖受损(impaired fasting glucose,IFG)和糖耐量受损(impaired glucose tolerance,IGT),卒中发生后尚可出现应激性高血糖。本文重点介     

Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury

Our previous RNA sequencing study showed that the long non-coding RNA ischemia-related factor Vof-16(lncRNA Vof-16)was upregulated after spinal cord injury,but its precise role in spinal cord injury remains unclear.Bioinformatics predictions have indicated that lncRNA Vof-16 may participate in the pathophysiological processes of inflammation and apoptosis.PC12 cells were transfected with a pHBLV-U6-MCS-CMV-ZsGreen-PGK-PURO vector to express an lncRNA Vof-16 knockdown lentivirus and a pHLV-CMVIE-ZsGree-Puro vector to express an lncRNA Vof-16 overexpression lentivirus.The overexpression of lncRNA Vof-16 inhibited PC12 cell survival,proliferation,migration,and neurite extension,whereas lncRNA Vof-16 knockdown lentiviral vector resulted in the opposite effects in PC12 cells.Western blot assay results showed that the overexpression of lncRNA Vof-16 increased the protein expression levels of interleukin 6,tumor necrosis factor-α,and Caspase-3 and decreased Bcl-2 expression levels in PC12 cells.Furthermore,we established rat models of spinal cord injury using the complete transection at T10.Spinal cord injury model rats were injected with the lncRNA Vof-16 knockdown or overexpression lentiviral vectors immediately after injury.At 7 days after spinal cord injury,rats treated with lncRNA Vof-16 knockdown displayed increased neuronal survival and enhanced axonal extension.At 8 weeks after spinal cord injury,rats treated with the lncRNA Vof-16 knockdown lentiviral vector displayed improved neurological function in the hind limb.Notably,lncRNA Vof-16 knockdown injection increased Bcl-2 expression and decreased tumor necrosis factor-αand Caspase-3 expression in treated animals.Rats treated with the lncRNA Vof-16 overexpression lentiviral vector displayed opposite trends.These findings suggested that lncRNA Vof-16 is associated with the regulation of inflammation and apoptosis.The inhibition of lncRNA Vof-16 may be useful for promoting nerve regeneration and functional recovery after spinal cord injury.The experiments were approved by the Institutional Animal Care and Use Committee of Guangdong Medical University,China.     

Combined therapy of intensive statin plus intravenous rt-PA in acute ischemic stroke: the INSPIRE randomized clinical trial

Journal of Neurology - To investigate the safety and efficacy of intensive statin in the acute phase of ischemic stroke after intravenous thrombolysis therapy. A total of 310 stroke patients...