Anesthesia of a woman with extreme morbid obesity (260 kg)

Patients with morbid obesity present a series of functional and morphologic alterations and require a careful planning for anesthetic management. We report a case of a woman weighing 260 kg who was operated on twice for the treatment of her base condition. In the first operation, general anesthesia was carried out and in the second one, epidural anesthesia was conducted. Main complications included hypoxemia and hypercapnia which persisted during the first week after operation carried out under general anesthesia.     

Stress cardiomyopathy in thromboembolic arterial disease.

Apical ballooning is a novel clinical entity reported in different contexts of physical and psychological stress, which is more common in middle-aged women. Of unknown etiology, the syndrome is characterized by a sudden and transient dilatation of the left ventricular apex in the absence of obstructive atherosclerotic coronary disease or evidence of myocardial necrosis, with total late recovery of ventricular function. The authors report the case of a 53-year-old woman who was admitted to the emergency room with left arm ischemia and low cardiac output, requiring ventilatory support. Left catheterization showed typical medial and apical myocardial dysfunction, with normal coronary arteries. Transesophageal echocardiography revealed a thrombus attached to the lower face of the aortic arch, which probably explained the thromboembolism of the arm but was unlikely to be the cause of the left ventricular dysfunction since there were no enzymatic or electrocardiographic signs of myocardial necrosis and normal wall motion was fully recovered.     

A rare case of chorioamnionitis by Morganella morganii complicated by septicemia and adult respiratory distress syndrome.

Morganella morganii, a gram-negative bacterium, usually infects older patients with urinary catheters, but does not commonly affect pregnant women. In this report we present a case of chorioamnionitis caused by Morganella morganii. The case was complicated by a life-threatening Adult Respiratory Distress Syndrome.     

Effect of cyclosporin a on proteinuria in patients with Alport's syndrome

Eight patients with Alport's syndrome and massive proteinuria (129±60.57 mg/m² per hour) were treated with cyclosporin A (CyA) for 8 months. The average dose of CyA administered to all patients was 4.21±0.26 mg/kg per day and blood CyA levels of 63.4±4.1 ng/ml were attained. In five patients, proteinuria abated during the 3rd week of treatment. In the remaining three, all of whom had low creatinine clearance (82.0, 46.0 and 43.2 ml/min per 1.73 m² respectively), proteinuria persisted but at levels lower than before treatment: 32.5±15.9 mg/m² per hour versus 183.3±29.7 mg/m² per hour. No permanent decrease in creatinine clearance was observed in any of these patients throughout treatment. In those patients in whom proteinuria abated, it reappeared 2 weeks after discontinuation of CyA treatment. We observed no significant increases in angiotensin II plasma levels in our patients during CyA administration. Although we have shown that CyA will reduce massive proteinuria in patients with Alport's syndrome, we cannot yet recommend its use as a therapeutic measure.     

Physiological and subjective effects of traffic noise: the role of negative self-statements.

This study assesses physiological and subjective effects of traffic noise and the mediator role that negative self-statements play. 84 female students underwent a Physiological Reaction Test to two 15 min presentations of high intensity traffic noise (85-95 dB) under two Noise conditions--with and without negative self-statements. Half of the subjects were given specific instructions to increase the credibility of the self-statements. Dependent variables were frontal EMG, electrodermal variables (conductance level and number of responses) and subjective tension. Traffic noise provoked subjective tension and physiological responses. Only the number of electrodermal responses habituated between noise presentations, the rest of the physiological variables did not habituate. Negative self-statements had the greatest effect on frontal EMG. In fact, only the noise with negative self-statements condition produced a significant EMG increase in the first part of the Test. Instructions increased subjective tension and also increased the effect of the self-statements on the electrodermal variables. The implications of these results for psychosomatic problems and the importance of negative self-statements are discussed.