全文获取类型
收费全文 | 14429篇 |
免费 | 1068篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 157篇 |
儿科学 | 376篇 |
妇产科学 | 329篇 |
基础医学 | 2374篇 |
口腔科学 | 298篇 |
临床医学 | 1388篇 |
内科学 | 3590篇 |
皮肤病学 | 364篇 |
神经病学 | 1286篇 |
特种医学 | 447篇 |
外科学 | 1456篇 |
综合类 | 92篇 |
一般理论 | 6篇 |
预防医学 | 1168篇 |
眼科学 | 128篇 |
药学 | 1109篇 |
中国医学 | 34篇 |
肿瘤学 | 928篇 |
出版年
2023年 | 111篇 |
2022年 | 145篇 |
2021年 | 262篇 |
2020年 | 260篇 |
2019年 | 328篇 |
2018年 | 341篇 |
2017年 | 285篇 |
2016年 | 354篇 |
2015年 | 396篇 |
2014年 | 478篇 |
2013年 | 650篇 |
2012年 | 888篇 |
2011年 | 887篇 |
2010年 | 531篇 |
2009年 | 472篇 |
2008年 | 816篇 |
2007年 | 774篇 |
2006年 | 780篇 |
2005年 | 737篇 |
2004年 | 631篇 |
2003年 | 604篇 |
2002年 | 522篇 |
2001年 | 341篇 |
2000年 | 265篇 |
1999年 | 261篇 |
1998年 | 138篇 |
1997年 | 102篇 |
1996年 | 109篇 |
1995年 | 102篇 |
1994年 | 96篇 |
1993年 | 92篇 |
1992年 | 196篇 |
1991年 | 216篇 |
1990年 | 211篇 |
1989年 | 211篇 |
1988年 | 170篇 |
1987年 | 160篇 |
1986年 | 178篇 |
1985年 | 170篇 |
1984年 | 109篇 |
1983年 | 128篇 |
1982年 | 96篇 |
1981年 | 65篇 |
1979年 | 104篇 |
1978年 | 85篇 |
1977年 | 66篇 |
1976年 | 53篇 |
1975年 | 51篇 |
1974年 | 60篇 |
1973年 | 60篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
Anders Elm Pedersen Esben Gjerløff Wedebye Schmidt Jesper Freddie Sørensen Carsten Faber Boye Schnack Nielsen Kim Holmstrøm Silje Haukali Omland Peter Tougaard Søren Skov Bo Bang 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(7):547-555
TL1A is a TNF‐like cytokine which has been shown to co‐stimulate TH1 and TH17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is known about expression and induction in psoriasis. Indeed, the pathogenesis in psoriasis is still not fully understood and it is speculated that cytokines other than TNF‐α are important in subsets of patients. Also, for patients with severe disease that are treated with systemic anti‐TNF‐α blockade, novel candidates to be used as disease and response biomarkers are of high interest. Here, we demonstrate TL1A expression in biopsies from psoriatic lesions. Also, we investigated spontaneous and induced TL1A secretion from PBMCs and blood levels from a cohort of psoriasis patients. Here, increased spontaneous secretion from PBMCs was observed as compared to healthy controls and a small subset of patients had highly elevated TL1A in the blood. Interestingly, activation of PBMCs with various cytokines showed a decreased sensitivity for TL1A activation in psoriasis patients compared to healthy controls.TL1A levels in blood and biopsies could not be correlated with disease activity with this patient cohort. Thus, additional large‐scale studies are warranted to investigate TL1A as a biomarker. 相似文献
4.
Very preterm children are at increased risk of reduced processing speed at 5 years of age,predicted by typical complications of prematurity and prenatal smoking 下载免费PDF全文
5.
6.
7.
Erik de Bakker Mirthe A. M. van der Putten Martijn W. Heymans Sander W. Spiekstra Taco Waaijman Liselotte Butzelaar Vera L. Negenborn Vivian K. Beekman Erman O. Akpinar Thomas Rustemeyer Frank B. Niessen Susan Gibbs 《Experimental dermatology》2021,30(1):169-178
Unpredictable hypertrophic scarring (HS) occurs after approximately 35% of all surgical procedures and causes significant physical and psychological complaints. Parallel to the need to understanding the mechanisms underlying HS formation, a prognostic tool is needed. The objective was to determine whether (systemic) immunological differences exist between patients who develop HS and those who develop normotrophic scars (NS) and to assess whether those differences can be used to identify patients prone to developing HS. A prospective cohort study with NS and HS groups in which (a) cytokine release by peripheral blood mononuclear cells (PBMC) and (b) the irritation threshold (IT) after an irritant (sodium lauryl sulphate) patch test was evaluated. Univariate regression analysis of PBMC cytokine secretion showed that low MCP‐1, IL‐8, IL‐18 and IL‐23 levels have a strong correlation with HS (P < .010‐0.004; AUC = 0.790‐0.883). Notably, combinations of two or three cytokines (TNF‐a, MCP‐1 and IL‐23; AUC: 0.942, Nagelkerke R2: 0.727) showed an improved AUC indicating a better correlation with HS than single cytokine analysis. These combination models produce good prognostic results over a broad probability range (sensitivity: 93.8%, specificity 86.7%, accuracy 90,25% between probability 0.3 and 0.7). Furthermore, the HS group had a lower IT than the NS group and an accuracy of 68%. In conclusion, very fundamental immunological differences exist between individuals who develop HS and those who do not, whereas the cytokine assay forms the basis of a predictive prognostic test for HS formation, the less invasive, easily performed irritant skin patch test is more accessible for daily practice. 相似文献
8.
9.
Ebadi Maryam Bhanji Rahima A. Mazurak Vera C. Montano-Loza Aldo J. 《Journal of gastroenterology》2019,54(10):845-859
Journal of Gastroenterology - Sarcopenia (severe muscle depletion) is a prevalent muscle abnormality in patients with cirrhosis that confers poor prognosis both pre- and post-liver transplantation.... 相似文献
10.
The Partial Report Span of Apprehension test has been found to detect cognitive deficits in some first degree relatives of schizophrenic patients. To assess the relative contribution of genetic vs. environmental factors on this measure, 19 monozygotic and 14 dizygotic female twin pairs, selected from a normal population, were tested on the Span of Apprehension test and an IQ test. Both Span of Apprehension test performance and IQ score had high heritabilities: 0.65 and 0.71, respectively. The mode of transmission for performance on the Span of Apprehension test appears to operate in a nonadditive manner. A multivariate behavioral-genetic model applied to the Span of Apprehension and IQ measures indicated that slightly less than half of the genetic effects important for the Span of Apprehension test are found in common with the genetic factors important for IQ. The phenotypic correlation between the Span of Apprehension and IQ measures can be attributed entirely to genetic factors. The influence of unique genetic components in the performance of the Span of Apprehension test in the general population heightens the promise of this measure as a genetic marker for schizophrenia. 相似文献