Does postural stability affect grasping?

We examined whether challenging upright stance influences the execution of a grasping task. Participants reached to grasp a small sphere while standing either on a stable surface or on foam. Before reaching for the sphere, participants exhibited more body sway and greater fluctuations in the centre of pressure when standing on foam. While reaching for the sphere, the overall body posture changed less when standing on foam than when standing on the stable surface. The digits’ and wrist's movements towards the sphere were no different when standing on foam than when standing on the stable surface. Presumably, the redundancy in the way movements can be performed is exploited to choose the most suitable changes in joint angles to achieve the desired movements of the digits under the prevailing conditions.     

Maternally acquired genotoxic Escherichia coli alters offspring’s intestinal homeostasis

The neonatal gut is rapidly colonized by a newly dominant group of commensal Escherichia coli strains among which a large proportion produces a genotoxin called colibactin. In order to analyze the short- and long-term effects resulting from such evolution, we developed a rat model mimicking the natural transmission of E. coli from mothers to neonates. Genotoxic and non-genotoxic E. coli strains were equally transmitted to the offspring and stably colonized the gut across generations. DNA damage was only detected in neonates colonized with genotoxic E. coli strains. Signs of genotoxic stress such as anaphase bridges, higher occurrence of crypt fission and accelerated renewal of the mature epithelium were detected at adulthood. In addition, we observed alterations of secretory cell populations and gut epithelial barrier. Our findings illustrate how critical is the genotype of E. coli strains acquired at birth for gut homeostasis at adulthood.     

Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndrome

The last ten years’ wide progress in the gut microbiota phylogenetic and functional characterization has been made evidencing dysbiosis in several gastrointestinal diseases including inflammatory bowel diseases and irritable bowel syndrome (IBS). IBS is a functional gut disease with high prevalence and negative impact on patient’s quality of life characterized mainly by visceral pain and/or discomfort, representing a good paradigm of chronic gut hypersensitivity. The IBS features are strongly regulated by bidirectional gut-brain interactions and there is increasing evidence for the involvement of gut bacteria and/or their metabolites in these features, including visceral pain. Further, gut microbiota modulation by antibiotics or probiotics has been promising in IBS. Mechanistic data provided mainly by animal studies highlight that commensals or probiotics may exert a direct action through bacterial metabolites on sensitive nerve endings in the gut mucosa, or indirect pathways targeting the intestinal epithelial barrier, the mucosal and/or systemic immune activation, and subsequent neuronal sensitization and/or activation.     

Uncommon manifestation of bleomycin-induced pulmonary toxicity in a patient with Hodgkin's disease.

Bleomycin is an antitumor antibiotic isolated from a strainof Streptomyces verticillus in 1966. It has been used successfullyto treat a variety of tumors, including squamous cell carcinomaof the head and neck, cervix, and esophagus, as well as germcell tumors and Hodgkin's and non-Hodgkin's lymphomas. The majorlimitation of bleomycin therapy is the potential for developinglife-threatening pulmonary toxicity, which most commonly     

Low protein Z levels, but not the intron F G79A polymorphism, are associated with unexplained pregnancy loss

Introduction

The present case-control study was designed in order to investigate the association between plasma protein Z (PZ) levels, the intron F G79A polymorphism and unexplained pregnancy loss.

Materials and Methods

51 women with at least two consecutive or three non-consecutive fetal losses between the 8th and 12th week of gestation and 47 apparently healthy parous women of reproductive age with no history of pregnancy loss (controls) were enrolled. Allele frequencies of the PZ intron F G79A polymorphism and PZ levels were measured.

Results

PZ levels (mg/L) were significantly lower in cases (mean±S.D. 1.28 ± 0.56) than controls (1.97 ± 0.76, p < 0.001) and in carriers of the A allele (1.46 ± 0.62), compared to GG homozygous subjects (1.72 ± 0.81, p = 0.044). A higher proportion of cases (41.2%) were PZ-deficient (< 1 mg/L), compared to controls (10.6%, p = 0.001). No significant difference in the frequency of at least one A allele carriers was observed between cases (39.2%) and controls (40.4%).

Conclusion(s)

It is possible that low PZ levels are a novel risk factor for unexplained recurrent miscarriage or fetal death. The presence of the F 79A allele is associated with significantly lower PZ levels, but, in the present study, was unrelated to unexplained early pregnancy loss.     

Investigating the stabilising and mobilising features of footedness

This study investigated lower limb laterality for stabilising and mobilising actions in 10 right- and 10 mixed-footed participants by determining, via the Waterloo Footedness Questionnaire--Revised (WFQ-R), the preferred foot in carrying out a range of stabilising and mobilising activities and by recording foot performance on standing balance and ball juggling. The log odds ratio (lambda score) was used to quantify the degree of laterality in task performance. Differences between the stability and mobility scores and the two groups were analyzed using a 2 (Group) x 2 (Task) ANOVA model with repeated measures on Task. Right- and mixed-footed participants differed significantly in the stability but not in the mobility items of the WFQ-R. No significant between-group differences were noted in either ball-juggling or standing balance performance. Mixed-footed participants had a significant right-left foot difference in standing balance, whereas both groups had a significant right-left foot difference in ball juggling. It is concluded that preference is not a steady attribute across the mobility and stability items of the WFQ-R and appears to be dependent on the behavioural context of a particular task. Results further indicated a lack of concordance between questionnaire and performance-based measures suggesting that these two methods of measuring laterality may be indicators of different underlying factors.