全文获取类型
收费全文 | 1705562篇 |
免费 | 117778篇 |
国内免费 | 2440篇 |
专业分类
耳鼻咽喉 | 23816篇 |
儿科学 | 56506篇 |
妇产科学 | 48341篇 |
基础医学 | 259277篇 |
口腔科学 | 45910篇 |
临床医学 | 149033篇 |
内科学 | 327398篇 |
皮肤病学 | 36427篇 |
神经病学 | 128163篇 |
特种医学 | 66149篇 |
外国民族医学 | 410篇 |
外科学 | 260330篇 |
综合类 | 33402篇 |
现状与发展 | 2篇 |
一般理论 | 444篇 |
预防医学 | 126184篇 |
眼科学 | 39332篇 |
药学 | 130437篇 |
4篇 | |
中国医学 | 3384篇 |
肿瘤学 | 90831篇 |
出版年
2018年 | 16605篇 |
2016年 | 14170篇 |
2015年 | 16153篇 |
2014年 | 22135篇 |
2013年 | 33510篇 |
2012年 | 46877篇 |
2011年 | 50741篇 |
2010年 | 29772篇 |
2009年 | 27468篇 |
2008年 | 48225篇 |
2007年 | 52552篇 |
2006年 | 52845篇 |
2005年 | 51433篇 |
2004年 | 49776篇 |
2003年 | 48226篇 |
2002年 | 47202篇 |
2001年 | 75144篇 |
2000年 | 77098篇 |
1999年 | 65110篇 |
1998年 | 18479篇 |
1997年 | 16289篇 |
1996年 | 16534篇 |
1995年 | 15591篇 |
1994年 | 14649篇 |
1993年 | 13694篇 |
1992年 | 52061篇 |
1991年 | 52480篇 |
1990年 | 52030篇 |
1989年 | 50645篇 |
1988年 | 47153篇 |
1987年 | 46337篇 |
1986年 | 43977篇 |
1985年 | 42045篇 |
1984年 | 31354篇 |
1983年 | 27193篇 |
1982年 | 15762篇 |
1981年 | 14071篇 |
1979年 | 29899篇 |
1978年 | 21065篇 |
1977年 | 17981篇 |
1976年 | 17423篇 |
1975年 | 19530篇 |
1974年 | 22810篇 |
1973年 | 21969篇 |
1972年 | 20733篇 |
1971年 | 19466篇 |
1970年 | 18160篇 |
1969年 | 17287篇 |
1968年 | 16298篇 |
1967年 | 14440篇 |
排序方式: 共有10000条查询结果,搜索用时 531 毫秒
1.
Kinase alterations are increasingly recognised as oncogenic drivers in mesenchymal tumours. Infantile fibrosarcoma and the related renal tumour, congenital mesoblastic nephroma, were among the first solid tumours shown to harbour recurrent tyrosine kinase fusions, with the canonical ETV6::NTRK3 fusion identified more than 20 years ago. Although targeted testing has long been used in diagnosis, the advent of more robust sequencing techniques has driven the discovery of kinase alterations in an array of mesenchymal tumours. As our ability to identify these genetic alterations has improved, as has our recognition and understanding of the tumours that harbour these alterations. Specifically, this study will focus upon mesenchymal tumours harbouring NTRK or other kinase alterations, including tumours with an infantile fibrosarcoma-like appearance, spindle cell tumours resembling lipofibromatosis or peripheral nerve sheath tumours and those occurring in adults with a fibrosarcoma-like appearance. As publications describing the histology of these tumours increase so, too, do the variety kinase alterations reported, now including NTRK1/2/3, RET, MET, RAF1, BRAF, ALK, EGFR and ABL1 fusions or alterations. To date, these tumours appear locally aggressive and rarely metastatic, without a clear link between traditional features used in histological grading (e.g. mitotic activity, necrosis) and outcome. However, most of these tumours are amenable to new targeted therapies, making their recognition of both diagnostic and therapeutic import. The goal of this study is to review the clinicopathological features of tumours with NTRK and other tyrosine kinase alterations, discuss the most common differential diagnoses and provide recommendations for molecular confirmation with associated treatment implications. 相似文献
2.
3.
Journal of Behavioral Medicine - Evidence supports the use of graphic warnings to educate the public about the health harms of smoking and suggests warnings eliciting negative emotional responses... 相似文献
4.
The adrenal cortex gives rise to a biologically heterogenous group of neoplasms, each with a distinct morphology, antigen expression and molecular profile. Adrenal cortical adenomas have excellent prognosis and are usually cured by surgical resection alone, while adrenal cortical carcinomas are very aggressive tumors with a poor prognosis regardless of therapy. These tumors are rare and often challenging for a pathologist to diagnose, as significant overlap exists between benign and malignant lesions in some cases. In this review, we attempt to summarize most important histologic and clinical features of adrenal cortical adenomas and carcinomas, clarify the use of different grading systems, the use of special stains and the differential diagnosis for practicing pathologists. Most relevant hereditary syndromes associated with adrenal cortical tumors are listed. Updates in molecular alterations in adrenal cortical neoplasms and hyperplastic diseases as well as their clinical significance and potential therapeutic implications are also discussed. 相似文献
5.
6.
7.
8.
9.
Kara S. Tanaka MD Veronica R. Andaya BA Steven W. Thorpe MD Kenneth R. Gundle MD James B. Hayden MD Yee-Cheen Duong MD Raffi S. Avedian MD David G. Mohler MD Lee J. Morse MD Melissa N. Zimel MD Richard J. O'Donnell MD Andrew Fang MD Robert Lor Randall MD Tina H. Tran BS Christin New BA Rosanna L. Wustrack MD other members of Study Group FORCE 《Journal of surgical oncology》2023,127(1):148-158
10.
Vilar-Compte Mireya Gaitán-Rossi Pablo Félix-Beltrán Lucía Bustamante Arturo V. 《Journal of immigrant and minority health / Center for Minority Public Health》2022,24(1):65-77
Journal of Immigrant and Minority Health - COVID-19 has disproportionally affected underrepresented minorities (URM) and low-income immigrants in the United States. The aim of the study is to... 相似文献