全文获取类型
收费全文 | 256677篇 |
免费 | 11449篇 |
国内免费 | 531篇 |
专业分类
耳鼻咽喉 | 3735篇 |
儿科学 | 7579篇 |
妇产科学 | 6265篇 |
基础医学 | 36542篇 |
口腔科学 | 7885篇 |
临床医学 | 16478篇 |
内科学 | 55973篇 |
皮肤病学 | 7147篇 |
神经病学 | 21634篇 |
特种医学 | 6719篇 |
外国民族医学 | 5篇 |
外科学 | 31472篇 |
综合类 | 1286篇 |
一般理论 | 51篇 |
预防医学 | 27894篇 |
眼科学 | 6447篇 |
药学 | 19558篇 |
中国医学 | 910篇 |
肿瘤学 | 11077篇 |
出版年
2023年 | 1342篇 |
2022年 | 983篇 |
2021年 | 3829篇 |
2020年 | 2191篇 |
2019年 | 4205篇 |
2018年 | 7663篇 |
2017年 | 4918篇 |
2016年 | 5029篇 |
2015年 | 5653篇 |
2014年 | 6057篇 |
2013年 | 9466篇 |
2012年 | 15838篇 |
2011年 | 16556篇 |
2010年 | 8312篇 |
2009年 | 6126篇 |
2008年 | 13427篇 |
2007年 | 14537篇 |
2006年 | 13882篇 |
2005年 | 13540篇 |
2004年 | 12660篇 |
2003年 | 11834篇 |
2002年 | 11229篇 |
2001年 | 7739篇 |
2000年 | 8394篇 |
1999年 | 6647篇 |
1998年 | 1274篇 |
1992年 | 3468篇 |
1991年 | 3209篇 |
1990年 | 3077篇 |
1989年 | 2695篇 |
1988年 | 2527篇 |
1987年 | 2422篇 |
1986年 | 2418篇 |
1985年 | 2262篇 |
1984年 | 1645篇 |
1983年 | 1414篇 |
1979年 | 1834篇 |
1978年 | 1196篇 |
1977年 | 1116篇 |
1976年 | 1064篇 |
1975年 | 1297篇 |
1974年 | 1681篇 |
1973年 | 1659篇 |
1972年 | 1571篇 |
1971年 | 1495篇 |
1970年 | 1451篇 |
1969年 | 1516篇 |
1968年 | 1539篇 |
1967年 | 1365篇 |
1966年 | 1199篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Molnár B. Aroca S. Dobos A. Orbán K. Szabó J. Windisch P. Stähli A. Sculean A. 《Clinical oral investigations》2022,26(12):7135-7142
Clinical Oral Investigations - To evaluate t he long-term outcomes following treatment of RT 1 multiple adjacent gingival recessions (MAGR) using the modified coronally advanced tunnel (MCAT) with... 相似文献
2.
Patrick W. Keeley Mikayla C. Lebo Jordan D. Vieler Jason J. Kim Ace J. St. John Benjamin E. Reese 《The Journal of neuroscience》2021,41(1):103
Amacrine cells of the retina are conspicuously variable in their morphologies, their population demographics, and their ensuing functions. Vesicular glutamate transporter 3 (VGluT3) amacrine cells are a recently characterized type of amacrine cell exhibiting local dendritic autonomy. The present analysis has examined three features of this VGluT3 population, including their density, local distribution, and dendritic spread, to discern the extent to which these are interrelated, using male and female mice. We first demonstrate that Bax-mediated cell death transforms the mosaic of VGluT3 cells from a random distribution into a regular mosaic. We subsequently examine the relationship between cell density and mosaic regularity across recombinant inbred strains of mice, finding that, although both traits vary across the strains, they exhibit minimal covariation. Other genetic determinants must therefore contribute independently to final cell number and to mosaic order. Using a conditional KO approach, we further demonstrate that Bax acts via the bipolar cell population, rather than cell-intrinsically, to control VGluT3 cell number. Finally, we consider the relationship between the dendritic arbors of single VGluT3 cells and the distribution of their homotypic neighbors. Dendritic field area was found to be independent of Voronoi domain area, while dendritic coverage of single cells was not conserved, simply increasing with the size of the dendritic field. Bax-KO retinas exhibited a threefold increase in dendritic coverage. Each cell, however, contributed less dendrites at each depth within the plexus, intermingling their processes with those of neighboring cells to approximate a constant volumetric density, yielding a uniformity in process coverage across the population.SIGNIFICANCE STATEMENT Different types of retinal neuron spread their processes across the surface of the retina to achieve a degree of dendritic coverage that is characteristic of each type. Many of these types achieve a constant coverage by varying their dendritic field area inversely with the local density of like-type neighbors. Here we report a population of retinal amacrine cells that do not develop dendritic arbors in relation to the spatial positioning of such homotypic neighbors; rather, this cell type modulates the extent of its dendritic branching when faced with a variable number of overlapping dendritic fields to approximate a uniformity in dendritic density across the retina. 相似文献
3.
4.
Vilar-Compte Mireya Gaitán-Rossi Pablo Félix-Beltrán Lucía Bustamante Arturo V. 《Journal of immigrant and minority health / Center for Minority Public Health》2022,24(1):65-77
Journal of Immigrant and Minority Health - COVID-19 has disproportionally affected underrepresented minorities (URM) and low-income immigrants in the United States. The aim of the study is to... 相似文献
5.
6.
7.
8.
Bela Anand-Apte Jennifer R. Chao Ruchira Singh Heidi Stöhr 《Journal of neuroscience research》2019,97(1):88-97
Sorsby fundus dystrophy (SFD), an autosomal dominant, fully penetrant, degenerative disease of the macula, is manifested by symptoms of night blindness or sudden loss of visual acuity, usually in the third to fourth decades of life due to choroidal neovascularization (CNV). SFD is caused by specific mutations in the Tissue Inhibitor of Metalloproteinase-3, (TIMP3) gene. The predominant histo-pathological feature in the eyes of patients with SFD are confluent 20–30 m thick, amorphous deposits found between the basement membrane of the retinal pigment epithelium (RPE) and the inner collagenous layer of Bruch's membrane. SFD is a rare disease but it has generated significant interest because it closely resembles the exudative or “wet” form of the more common age-related macular degeneration (AMD). In addition, in both SFD and AMD donor eyes, sub-retinal deposits have been shown to accumulate TIMP3 protein. Understanding the molecular functions of wild-type and mutant TIMP3 will provide significant insights into the patho-physiology of SFD and perhaps AMD. This review summarizes the current knowledge on TIMP3 and how mutations in TIMP3 cause SFD to provide insights into how we can study this disease going forward. Findings from these studies could have potential therapeutic implications for both SFD and AMD. 相似文献
9.
10.
Jose M. Morales Jose Angel Martinez-Flores Manuel Serrano Maria José Castro Francisco Javier Alfaro Florencio García Miguel Angel Martínez Amado Andrés Esther González Manuel Praga Estela Paz-Artal Antonio Serrano 《Journal of the American Society of Nephrology : JASN》2015,26(3):735-745
In the current immunosuppressive therapy era, vessel thrombosis is the most common cause of early graft loss after renal transplantation. The prevalence of IgA anti–β2-glycoprotein I antibodies (IgA-aB2GPI-ab) in patients on dialysis is elevated (>30%), and these antibodies correlate with mortality and cardiovascular morbidity. To evaluate the effect of IgA-aB2GPI-ab in patients with transplants, we followed all patients transplanted from 2000 to 2002 in the Hospital 12 de Octubre prospectively for 10 years. Presence of IgA-aB2GPI-ab in pretransplant serum was examined retrospectively. Of 269 patients, 89 patients were positive for IgA-aB2GPI-ab (33%; group 1), and the remaining patients were negative (67%; group 2). Graft loss at 6 months post-transplant was significantly higher in group 1 (10 of 89 versus 3 of 180 patients in group 2; P=0.002). The most frequent cause of graft loss was thrombosis of the vessels, which was observed only in group 1 (8 of 10 versus 0 of 3 patients in group 2; P=0.04). Multivariate analysis showed that the presence of IgA-aB2GPI-ab was an independent risk factor for early graft loss (P=0.04) and delayed graft function (P=0.04). There were no significant differences regarding patient survival between the two groups. Graft survival was similar in both groups after 6 months. In conclusion, patients with pretransplant IgA-aB2GPI-ab have a high risk of early graft loss caused by thrombosis and a high risk of delayed graft function. Therefore, pretransplant IgA-aB2GPI-ab may have a detrimental effect on early clinical outcomes after renal transplantation. 相似文献