全文获取类型
收费全文 | 1699篇 |
免费 | 121篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 48篇 |
妇产科学 | 21篇 |
基础医学 | 267篇 |
口腔科学 | 28篇 |
临床医学 | 180篇 |
内科学 | 354篇 |
皮肤病学 | 22篇 |
神经病学 | 138篇 |
特种医学 | 70篇 |
外科学 | 209篇 |
综合类 | 16篇 |
一般理论 | 2篇 |
预防医学 | 160篇 |
眼科学 | 44篇 |
药学 | 96篇 |
肿瘤学 | 158篇 |
出版年
2023年 | 13篇 |
2022年 | 16篇 |
2021年 | 24篇 |
2020年 | 36篇 |
2019年 | 46篇 |
2018年 | 48篇 |
2017年 | 43篇 |
2016年 | 49篇 |
2015年 | 40篇 |
2014年 | 71篇 |
2013年 | 89篇 |
2012年 | 122篇 |
2011年 | 125篇 |
2010年 | 63篇 |
2009年 | 71篇 |
2008年 | 111篇 |
2007年 | 103篇 |
2006年 | 105篇 |
2005年 | 130篇 |
2004年 | 92篇 |
2003年 | 68篇 |
2002年 | 92篇 |
2001年 | 15篇 |
2000年 | 11篇 |
1999年 | 10篇 |
1998年 | 14篇 |
1997年 | 7篇 |
1996年 | 20篇 |
1995年 | 15篇 |
1994年 | 10篇 |
1993年 | 12篇 |
1992年 | 9篇 |
1991年 | 9篇 |
1990年 | 5篇 |
1989年 | 8篇 |
1988年 | 8篇 |
1987年 | 11篇 |
1986年 | 7篇 |
1985年 | 5篇 |
1984年 | 11篇 |
1983年 | 13篇 |
1982年 | 7篇 |
1980年 | 6篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1976年 | 4篇 |
1972年 | 7篇 |
1965年 | 3篇 |
1937年 | 5篇 |
排序方式: 共有1826条查询结果,搜索用时 15 毫秒
1.
Hoilund-Carlsen Poul F.; Johansen Allan; Vach Werner; Haghfelt Torben 《European heart journal》2006,27(9):1128-1129
We thank Geluk and Zijlstra for their kind words as well astheir considerations and proposals. The latter hits right intothe heart of the issue: should one stick to the anatomicparadigm urging us to detect and treat coronary stenoses andcalcifications rather than follow 相似文献
2.
Fixation of displaced femoral neck fractures: A comparison between sliding screw plate and four cancellous bone screws 总被引:1,自引:0,他引:1
Frank Madsen Frank Linde Erik Andersen Hanne Birke Inge Hvass Torben D. Poulsen 《Acta orthopaedica》1987,58(3):212-216
In a prospective, randomized trial, 104 consecutive patients with displaced femoral neck fractures were allocated either to fixation with a sliding screw plate or 4 ASIF cancellous bone screws. The patients were reexamined at fixed intervals to determine the time of union. The 2-year-cumulated rate of union was 64 per cent in the plate group and 84 per cent in the screw group. 相似文献
3.
Lise Pedersen Susanne Holck Torben Schiødt Karin Zedeler Henning T. Mouridsen 《Breast cancer research and treatment》1989,14(1):91-99
Summary One hundred thirty-one breast carcinomas with medullary features, registered in the Danish Breast Cancer Cooperative Group from 1977–1982, have been histopathologically reviewed by two senior pathologists and classified as typical medullary carcinoma (TMC), atypical medullary carcinoma (AMC), and non-medullary carcinoma (NMC). Diagnostic criteria were based on those put forward by Ridolfiet al. and Fisheret al. The procedure was repeated with an interval of about one year by both pathologists. The diagnostic interobserver agreement was 72% with a Kappa of 0.55. The intraobserver agreement was 77% and 63% with Kappa values of 0.64 and 0.44, respectively. To see whether the observed inter- and intraobserver variability had any prognostic implications, diagnostic subgroups for both pathologists were analyzed with Kaplan Meier plots for recurrence-free survival (RFS) and with log rank tests. In the first evaluation pathologist 1 segregated a group of TMC with a significantly better RFS than for the NMC group, and pathologist 2 segregated a group of TMC with a corresponding strong trend. These findings could not, however, be reproduced in the second evaluation. The study indicates that the criteria of TMC and AMC as proposed by Ridolfiet al. need to be sharpened and simplified in order to reduce inter-and intraobserver variability. Larger studies with a control group of infiltrating ductal carcinomas are mandatory to elucidate the clinical importance of the diagnoses of Typical and Atypical Medullary Carcinoma of the breast. 相似文献
4.
5.
Birgitte Lidegaard Frederiksen Merete Osler Henrik Harling Steen Ladelund Torben Jørgensen 《Social science & medicine (1982)》2009
This paper investigates the association between individually measured socioeconomic status (SES) and all-cause survival in colorectal cancer patients, and explores whether factors related to the patient, the disease, or the surgical treatment mediate the observed social gradient. 相似文献
6.
Clinical trial registration: a statement from the International Committee of Medical Journal Editors 下载免费PDF全文
7.
Ove Christensen Marek Simon Torben Randlev 《Pflügers Archiv : European journal of physiology》1990,415(1):37-46
We have used the patch-clamp technique to characterize three anion channels in the ventricular membrane of the choroid plexus epithelium from Necturus. The most frequently occurring channel had a nonlinear IV-curve. The conductance in excised patches with 112 mM chloride at both sides was 28 pS at 0 mV, increasing towards positive membrane potentials. The selectivity ratios were P
NaP
Cl 0.1 and
. SITS and furosemide (1 mM) on the inside reduces chloride flux to 0.15 and 0.37 times the control value. In attached patches, the most commonly observed channel had a conductance of 7.5 pS. The single-channel current for this channel reversed direction at 15 mV hyperpolarization, indicating accumulation of chloride to a factor of 1.8 above equilibrium. External stimulation of the tissue by theophylline, IBMX and dbcAMP, or by hypotonic shock did not increase the activity of this channel. In very few excised patches, we have observed a chloride channel with a conductance of 7 pS with 112 mM chloride at both sides. The 7 pS channel appears to be identical to a 2 pS channel found in attached patches. The 2 pS channel was not normally active in attached patches but was activated in 28% of the patches by external stimulation. Finally, in few excised patches we have found a 375 pS channel which inactivates within seconds when membrane potential is stepped from 0 mV to a value that differs more than 10–20 mV from zero. The channel did not conduct gluconate but
and P
NaP
Cl 0.1. Internal SITS and furosemide (1 mM) reduced chloride flux to 0.3 and 0.5 times the control value. The channel was never seen in attached patches. The current carried through these channels can not account for the transepithelial steady state Cl–-flux measured by microelectrodes. KCl exit from the cell is suggested to be carried by KCl-cotransport or by channels that are too small to be seen in patch-clamp experiments. 相似文献
8.
Simeon P. Cairns John A. Flatman Torben Clausen 《Pflügers Archiv : European journal of physiology》1995,430(6):909-915
An increased extracellular K+ concentration ([K+]0) is thought to cause muscle fatigue. We studied the effects of increasing [K+]0 from 4 mM to 8–14 mM on tetanic contractions in isolated bundles of fibres and whole soleus muscles from the rat. Whereas there was little depression of force at a [K+]0 of 8–9 mM, a further small increase in [K+]0 to 11–14 mM resulted in a large reduction of force. Tetanus depression at 11 mM [K+]o was increased when using weaker stimulation pulses and decreased with stronger pulses. Whereas the tetanic force/resting membrane potential (E
M) relation showed only moderate force depression with depolarization from –74 to –62 mV, a large reduction of force occurred whenE
M fell to –53 mV. The implications of these relations to fatigue are discussed. Partial inhibition of the Na+-K+ pump with ouabain (10–6 M) caused additional force loss at 11 mM [K+]0. Salbutamol, insulin, or calcitonin gene-related peptide all stimulated the Na+-K+ pump in muscles exposed to 11 mM [K+
0] and induced an average 26–33% recovery of tetanic force. When using stimulation pulses of 0.1 ms, instead of the standard 1.0-ms pulses, force recovery with these agents was 41–44% which was significantly greater (P < 0.025). Only salbutamol caused any recovery ofE
M (1.3 mV). The observations suggest that the increased Na+ concentration difference across the sarcolemma, following Na+-K+ pump stimulation, has an important role in restoring excitability and force. 相似文献
9.
Neutralization test for BK virus: plaque reduction detected by immunoperoxidase staining 总被引:2,自引:0,他引:2
We developed an immunoperoxidase staining test to detect structural antigens of BK virus (BKV) in Vero cell cultures. This test was used to examine the neutralizing activity of human and immunized animal sera. It was shown that sera positive for BKV antibodies measured by hemagglutination inhibition test and enzyme-linked immunosorbent assay (ELISA) were able to prevent expression of BKV structural antigens in cell cultures. The correlation between titers in the hemagglutination inhibition test, levels of BKV IgG measured by ELISA, and the titers assayed by the immunoperoxidase neutralization test was high. We suggest that this type of test may be used instead of conventional neutralization tests for other viruses with slowly developing cytopathogenic effects. 相似文献
10.
Henrik Ewald Ole Mors Tracey Flint Ursula Friedrich Hans Eiberg Torben A. Kruse 《American journal of medical genetics. Part A》1995,60(5):386-392
The long arm of chromosome 11 is one of the most interesting regions in the search for major genes involved in the etiology of manic-depressive illness. Several candidate genes have been identified, including the gene encoding the dopamine D2 receptor, the M1 muscarinic receptor, and porfobillinogen deaminase. Furthermore, different families with co-segregation of psychiatric illness and structural chromosome abnormalities involving regions 11q21, 11q22.3, and 11q25 have been reported. Using narrow as well as broad phenotypic models, conservative genetic parameters, models with dominant or recessive modes of inheritance, and various methods to reduce misclassification, the present study did not find evidence for a major gene causing manic-depressive illness on the long arm of chromosome 11. In the broader phenotypic models multi-point analyses excluded at least 11q14 to 11q23.3, approximately 60 cM, even in one large family. Assuming homogeneity close linkage to DRD2 was excluded for all dominant models, and also in the affecteds-only analyses in the large family alone. © 1995 Wiley-Liss, Inc. 相似文献