全文获取类型
收费全文 | 13286篇 |
免费 | 894篇 |
国内免费 | 72篇 |
专业分类
耳鼻咽喉 | 144篇 |
儿科学 | 463篇 |
妇产科学 | 258篇 |
基础医学 | 1385篇 |
口腔科学 | 206篇 |
临床医学 | 1418篇 |
内科学 | 2634篇 |
皮肤病学 | 165篇 |
神经病学 | 1149篇 |
特种医学 | 386篇 |
外科学 | 1822篇 |
综合类 | 258篇 |
一般理论 | 14篇 |
预防医学 | 1350篇 |
眼科学 | 351篇 |
药学 | 1305篇 |
中国医学 | 28篇 |
肿瘤学 | 916篇 |
出版年
2023年 | 78篇 |
2022年 | 164篇 |
2021年 | 381篇 |
2020年 | 228篇 |
2019年 | 345篇 |
2018年 | 386篇 |
2017年 | 288篇 |
2016年 | 356篇 |
2015年 | 368篇 |
2014年 | 505篇 |
2013年 | 646篇 |
2012年 | 945篇 |
2011年 | 949篇 |
2010年 | 536篇 |
2009年 | 487篇 |
2008年 | 825篇 |
2007年 | 953篇 |
2006年 | 938篇 |
2005年 | 907篇 |
2004年 | 837篇 |
2003年 | 741篇 |
2002年 | 664篇 |
2001年 | 187篇 |
2000年 | 131篇 |
1999年 | 160篇 |
1998年 | 155篇 |
1997年 | 119篇 |
1996年 | 114篇 |
1995年 | 70篇 |
1994年 | 64篇 |
1993年 | 75篇 |
1992年 | 62篇 |
1991年 | 45篇 |
1990年 | 43篇 |
1989年 | 37篇 |
1988年 | 50篇 |
1987年 | 48篇 |
1986年 | 44篇 |
1985年 | 31篇 |
1984年 | 38篇 |
1983年 | 29篇 |
1982年 | 25篇 |
1981年 | 25篇 |
1980年 | 22篇 |
1979年 | 11篇 |
1977年 | 14篇 |
1975年 | 21篇 |
1973年 | 11篇 |
1971年 | 10篇 |
1970年 | 17篇 |
排序方式: 共有10000条查询结果,搜索用时 328 毫秒
1.
2.
3.
Christian Holm Hansen Shelley Lees Saidi Kapiga Janet Seeley Tony Barnett 《Global public health》2020,15(3):402-413
ABSTRACTMeasuring hope reliably and accurately remains an important research objective, not least in less prosperous settings where ‘holding on to hope’ may be critically important in the struggle against adverse life conditions. The State Hope Scale was designed for use in the US. Despite reported application in diverse cultures and using translations the scale has not been extensively validated outside US populations. This study contributes to a larger project exploring the measurement of hope and provides a critique of Snyder’s scale as used in a Tanzanian female population of 1021 urban microfinance participants. We evaluate the scale’s validity through assessment of the empirical distribution of scores, item response profiles, internal consistency and discriminatory ability. Participants mostly scored very high and many reached very near the maximum attainable score. Hardly any endorsed the negative half of the response scale. Several problems are discussed including poor discrimination and strong evidence of acquiescence response bias. We also found little association of the scale scores with hypothesised correlates of hope. Future improvements on the measurement of hope are recommended, especially in studies outside the narrow Western context in which the scale was devised. 相似文献
4.
5.
Harit Kapoor Kush Raj Lohani Tommy H. Lee Devendra K. Agrawal Sumeet K. Mittal 《CTS Clinical and Translational Science》2015,8(6):841-847
Esophageal adenocarcinoma is the fastest rising cancer in the United States. It develops from long‐standing gastroesophageal reflux disease which affects >20% of the general population. It carries a very poor prognosis with 5‐year survival <20%. The disease is known to sequentially progress from reflux esophagitis to a metaplastic precursor, Barrett''s esophagus and then onto dysplasia and esophageal adenocarcinoma. However, only few patients with reflux develop Barrett''s esophagus and only a minority of these turn malignant. The reason for this heterogeneity in clinical progression is unknown. To improve patient management, molecular changes which facilitate disease progression must be identified. Animal models can provide a comprehensive functional and anatomic platform for such a study. Rats and mice have been the most widely studied but disease homology with humans has been questioned. No animal model naturally simulates the inflammation to adenocarcinoma progression as in humans, with all models requiring surgical bypass or destruction of existing antireflux mechanisms. Valuable properties of individual models could be utilized to holistically evaluate disease progression. In this review paper, we critically examined the current animal models of Barrett''s esophagus, their differences and homologies with human disease and how they have shaped our current understanding of Barrett''s carcinogenesis. 相似文献
6.
7.
Sadanandavalli Retnaswami Chandra Pawan Raj Thomas Gregor Issac 《Indian journal of dermatology》2015,60(3):290-292
Neurodegeneration with brain iron accumulation (NBIA) is the term applied to a heterogeneous group of disorders resulting in iron deposition in the basal ganglia. Well-known phenotypic features are progressive regression with extra pyramidal involvement and a variable course. A 10-year-old child born to consanguineous parents presented with progressive generalized opisthotonic dystonia, retrocollis, oromandibular dyskinesias, apraxia for swallowing, optic atrophy and severe self-mutilation of lips. MR imaging showed brain iron accumulation. Other causes of self-mutilation were excluded. Early infantile onset, ophisthotonic dystonia with oromandibular dyskinesias and characteristic MR images are suggestive of NBIA. There is only one case reported in the literature of self-mutilation in this condition. 相似文献
8.
Jae Eun Choi Tyler Werbel Zhenping Wang Chia Chi Wu Tony L. Yaksh Anna Di Nardo 《Journal of dermatological science》2019,93(1):58-64
Background
Rosacea is a chronic inflammatory skin condition whose etiology has been linked to mast cells and the antimicrobial peptide cathelicidin LL-37. Individuals with refractory disease have demonstrated clinical benefit with periodic injections of onabotulinum toxin, but the mechanism of action is unknown.Objectives
To investigate the molecular mechanism by which botulinum toxin improves rosacea lesions.Methods
Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control. Mast cell degranulation was evaluated by β-hexosaminidase activity. Expression of botulinum toxin receptor Sv2 was measured by qPCR. The presence of SNAP-25 and VAMP2 was established by immunofluorescence. In vivo rosacea model was established by intradermally injecting LL-37 with or without onabotulinum toxin A pretreatment. Mast cell degranulation was assessed in vivo by histologic counts. Rosacea biomarkers were analyzed by qPCR of mouse skin sections.Results
Onabotulinum toxin A and B inhibited compound 48/80-induced degranulation of both human and murine mast cells. Expression of Sv2 was established in mouse mast cells. Onabotulinum toxin A and B increased cleaved SNAP-25 and decreased VAMP2 staining in mast cells respectively. In mice, injection of onabotulinum toxin A significantly reduced LL-37-induced skin erythema, mast cell degranulation, and mRNA expression of rosacea biomarkers.Conclusions
These findings suggest that onabotulinum toxin reduces rosacea-associated skin inflammation by directly inhibiting mast cell degranulation. Periodic applications of onabotulinum toxin may be an effective therapy for refractory rosacea and deserves further study. 相似文献9.
Toshiro Hara Rony Chanoch-Myers Nathan D. Mathewson Chad Myskiw Lyla Atta Lillian Bussema Stephen W. Eichhorn Alissa C. Greenwald Gabriela S. Kinker Christopher Rodman L. Nicolas Gonzalez Castro Hiroaki Wakimoto Orit Rozenblatt-Rosen Xiaowei Zhuang Jean Fan Tony Hunter Inder M. Verma Kai W. Wucherpfennig Itay Tirosh 《Cancer cell》2021,39(6):779-792.e11
- Download : Download high-res image (228KB)
- Download : Download full-size image
10.