全文获取类型
收费全文 | 131篇 |
免费 | 12篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 1篇 |
妇产科学 | 1篇 |
基础医学 | 23篇 |
口腔科学 | 8篇 |
临床医学 | 9篇 |
内科学 | 14篇 |
皮肤病学 | 1篇 |
神经病学 | 17篇 |
外科学 | 8篇 |
综合类 | 1篇 |
预防医学 | 14篇 |
眼科学 | 19篇 |
药学 | 14篇 |
中国医学 | 5篇 |
肿瘤学 | 4篇 |
出版年
2022年 | 4篇 |
2021年 | 3篇 |
2020年 | 6篇 |
2019年 | 8篇 |
2018年 | 7篇 |
2017年 | 6篇 |
2016年 | 4篇 |
2015年 | 6篇 |
2014年 | 8篇 |
2013年 | 7篇 |
2012年 | 17篇 |
2011年 | 18篇 |
2010年 | 18篇 |
2009年 | 8篇 |
2008年 | 8篇 |
2007年 | 4篇 |
2006年 | 5篇 |
2005年 | 2篇 |
2004年 | 1篇 |
2003年 | 1篇 |
2002年 | 2篇 |
排序方式: 共有143条查询结果,搜索用时 31 毫秒
1.
Ana Carolina G. Zanetti Tais Milena Pantaleão de Souza Larissa de Souza Tressoldi João Mazzoncini de Azevedo-Marques Gabriel Elias Corrêa-Oliveira Amanda Heloisa Santana da Silva Isabela dos Santos Martin Kelly Graziani Giacchero Vedana Lucilene Cardoso Sueli Aparecida Frari Galera Edilaine Cristina da Silva Gherardi-Donato 《Archives of Psychiatric Nursing》2018,32(3):390-395
BACKGROUND
Evidence suggests that expressed emotion (EE) and family burden (FB) are phenomena that interact, but there is a lack of studies that analyze this association in patients in first-episode psychosis.AIM
This study evaluated the relationship between EE and FB in relatives of patients in first-episode psychosis.METHOD
A convenience sample of 71 family members of patients being assisted in an outpatient care unit participated in the study. We used a form with sociodemographic and clinical variables of family members and patients, the Family Questionnaire-Brazilian Portuguese Version and the Brazilian version of the Burden Interview. The data were obtained via semi-structured interviews. Statistical analyses included Fisher's exact tests, Mann Whitney tests, Spearman correlations, and Student's t-tests.RESULTS
Our results showed high levels of EE and its component emotional over-involvement (EOI) among relatives, and a strong correlation between critical comments (CC) and EOI and FB measurements. In addition, family members with elevated EE levels showed higher means for FB and this difference was significant.CONCLUSIONS
Mental health nurses are expected to consider these concepts for proposing nursing interventions to first-episode psychosis patients and their relatives. 相似文献2.
3.
de Castro Sasahara TH Mayhew TM Rahal SC Fioretto ET Balieiro JC Ribeiro AA 《Journal of anatomy》2007,210(4):449-459
The effects of partial urethral obstruction on the detrusor muscle of rabbit urinary bladder were investigated using stereological sampling and estimation tools. Twelve female Norfolk rabbits (2.5-3.0 kg body weight) were divided into four groups: 3, 7 and 12 weeks after surgical intervention to produce a standard partial obstruction and unobstructed controls. Following removal, bladder axes (craniocaudal, dorsoventral and laterolateral) and organ weights were recorded. Bladders were prepared for light microscopy by multistage random sampling procedures. Stereological methods were used to estimate the volume of muscle and the packing density and total number of myocyte nuclei in each bladder. We also estimated mean myocyte volume and the mean cross-sectional area and length of myocytes. Group comparisons were made by one-way analysis of variance. Changes in bladder axes were mainly laterolateral and craniocaudal. Mean bladder weight increased roughly six-fold by 3 weeks and 17-fold by 12 weeks and was accompanied, on average, by 12- and 33-fold increases in total muscle volume. These variables did not differ at 3 and 7 weeks post-obstruction. Increases in muscle content were not accompanied by changes in packing densities but were associated with increases in the total numbers of myocyte nuclei (13-fold by 3 weeks, 28-fold by 12 weeks). Mean myocyte volume did not vary significantly between groups but cells in obstructed groups were shorter and wider. These findings support the notion that partial outflow obstruction leads to an increase in the number, but not mean volume, of myocytes. If due solely to myocyte mitosis, the total of 43 x 10(8) cells found at 12 weeks could be generated by the original complement of 15 x 10(7) cells if an average of only 2.1 x 10(6) new cells was produced every hour. In reality, even this modest proliferation rate is unlikely to be achieved because myocyte proliferation rates are very low and it is possible that new myocytes can arise by differentiation of mesenchymal or other precursor cells. 相似文献
4.
Moraes Tde M Rodrigues CM Kushima H Bauab TM Villegas W Pellizzon CH Brito AR Hiruma-Lima CA 《Journal of ethnopharmacology》2008,120(2):161-168
Ethnopharmacological relevance
Mangaba (Hancornia speciosa Gomez) is a medicinal plant frequently cited in ethnopharmacological inventories of the central region of Brazil against gastrointestinal disorders such as diarrhoea, ulcer, gastritis and stomachache.Aim of the study
The hydroalcoholic extract (HE) and infusion (BI) of Hancornia speciosa bark were investigated for their ability to prevent and heal rodent gastric ulcer.Materials and methods
The preventive and healing action of both preparations of Hancornia speciosa were evaluated in experimental models in rodents that simulated this disease in human gastric mucosa.Results
BI did not exert gastroprotective effect, in contrast to HE (500 mg/kg, p.o.) that decreased (p < 0.05) the severity of gastric damage induced by HCl/ethanol (52%), indomethacin/bethanechol (51%), stress (52%) or pylorus ligature experiments (54%). HE increased (p < 0.05) the pH and decreased acid output of gastric juice. This extract promoted increase of mucus amount (3.62 mg/wt. tissue vs. 5.81 mg/wt. tissue), healing action (67%) and displayed anti-Helicobacter pylori effect.Conclusions
The antiulcer action of Hancornia speciosa resulted in increase of gastric mucus formation and antioxidant properties of polymeric proanthocyanidins present in the bark composition of this medicinal plant. 相似文献5.
6.
Valderez Raposo de Mello Maira Tinte Rodrigues Tais Helena Mastrocinque Simone Paiva Laranjo Martins Olberes Vitor Braga de Andrade Eliana Biondi Medeiros Guidoni Daniel Kashiwamura Scheffer Dino Martini Filho Julio Toporovski Vanda Benini 《Pediatric nephrology (Berlin, Germany)》2010,25(3):453-460
The purpose of this study was to assess the results of therapy with mycophenolate mofetil (MMF) in children with idiopathic nephrotic syndrome (INS) who were both steroid- and cyclophosphamide-resistant. Treatment lasted a minimum of 6 months, and follow-up data were collected over a 2-year period. The children were divided into two groups: Group 1 (n?=?34) comprised patients who had received cyclosporine A (CsA) before the initiation of MMF therapy; Group 2 (n?=?18) comprised patients who received only MMF. Among the 34 patients of Group 1, complete and partial remission were achieved in seven (20.6%) and 13 patients (38.6%), respectively; there was no response in 14 patients (41.2%). Among the 18 patients in Group 2, complete and partial remission occurred in five (27.8%) and six (33.3%) patients, respectively; there was no response in seven patients (38.9%). Eight patients developed chronic kidney disease. The main side-effects were gastrointestinal complaints (n?=?11, 21%), recurring severe infections (n?=?1, 1.9%), and mild thrombocytopenia/leucopenia (n?=?1, 1.9%). MMF proved to be therapeutically effective in 59.5% of the cases. These beneficial effects need to be confirmed in studies with a long-term follow-up after discontinuation of the treatment. Our statistical analysis of the results of therapy with MMF did not reveal any significant difference between its use alone or following CsA administration. 相似文献
7.
Ruy A. N. Louzada Patricia F. Oliveira Joao Paulo A. Cavalcanti-de-Albuquerque Leandro Cunha-Carvalho Marcelo R. Baldanza Taís H. Kasai-Brunswick Regina C. S. Goldenberg Antonio C. Campos-de-Carvalho Joao P. S. Werneck-de-Castro 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2010,24(2):121-130
Purpose
The aim of this study was to investigate the impact of granulocyte-colony stimulating factor (G-CSF) administration on cardiac function of rats with chronic myocardial infarction through two different protocols: high dose short term and low dose long term protocols. 相似文献8.
Suárez R Santibáñez R Parra D Coppi AA Abrahão LM Sasahara TH Mpodozis J 《Journal of anatomy》2011,218(5):558-565
The vomeronasal system is crucial for social and sexual communication in mammals. Two populations of vomeronasal sensory neurons, each expressing Gαi2 or Gαo proteins, send projections to glomeruli of the rostral or caudal accessory olfactory bulb, rAOB and cAOB, respectively. In rodents, the Gαi2‐ and Gαo‐expressing vomeronasal pathways have shown differential responses to small/volatile vs. large/non‐volatile semiochemicals, respectively. Moreover, early gene expression suggests predominant activation of rAOB and cAOB neurons in sexual vs. aggressive contexts, respectively. We recently described the AOB of Octodon degus, a semiarid‐inhabiting diurnal caviomorph. Their AOB has a cell indentation between subdomains and the rAOB is twice the size of the cAOB. Moreover, their AOB receives innervation from the lateral aspect, contrasting with the medial innervation of all other mammals examined to date. Aiming to relate AOB anatomy with lifestyle, we performed a morphometric study on the AOB of the capybara, a semiaquatic caviomorph whose lifestyle differs remarkably from that of O. degus. Capybaras mate in water and scent‐mark their surroundings with oily deposits, mostly for male–male communication. We found that, similar to O. degus, the AOB of capybaras shows a lateral innervation of the vomeronasal nerve, a cell indentation between subdomains and heterogeneous subdomains, but in contrast to O. degus the caudal portion is larger than the rostral one. We also observed that four other caviomorph species present a lateral AOB innervation and a cell indentation between AOB subdomains, suggesting that those traits could represent apomorphies of the group. We propose that although some AOB traits may be phylogenetically conserved in caviomorphs, ecological specializations may play an important role in shaping the AOB. 相似文献
9.
10.