全文获取类型
收费全文 | 202篇 |
免费 | 7篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 24篇 |
妇产科学 | 4篇 |
基础医学 | 48篇 |
口腔科学 | 5篇 |
临床医学 | 28篇 |
内科学 | 47篇 |
皮肤病学 | 1篇 |
神经病学 | 11篇 |
特种医学 | 5篇 |
外科学 | 14篇 |
预防医学 | 13篇 |
眼科学 | 1篇 |
药学 | 2篇 |
肿瘤学 | 5篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 6篇 |
2020年 | 3篇 |
2019年 | 6篇 |
2018年 | 6篇 |
2017年 | 4篇 |
2016年 | 6篇 |
2015年 | 11篇 |
2014年 | 6篇 |
2013年 | 14篇 |
2012年 | 14篇 |
2011年 | 19篇 |
2010年 | 7篇 |
2009年 | 7篇 |
2008年 | 13篇 |
2007年 | 10篇 |
2006年 | 7篇 |
2005年 | 15篇 |
2004年 | 7篇 |
2003年 | 7篇 |
2002年 | 6篇 |
2001年 | 1篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 1篇 |
1997年 | 3篇 |
1995年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1978年 | 1篇 |
1977年 | 3篇 |
1974年 | 1篇 |
排序方式: 共有209条查询结果,搜索用时 15 毫秒
1.
Ambrozic A Avicin T Ichikawa K Kveder T Matsuura E Hojnik M Atsumi T Rozman B Koike T 《International immunology》2002,14(7):823-830
beta(2)-Glycoprotein I (beta(2)GPI) appears to be the major antigen for antiphospholipid antibodies (aPL) in patients with antiphospholipid syndrome (APS). In early infancy, virtually all children initiate transient immune response to non-pathogenic nutritional antigens, which fails to terminate in children with atopic diseases. To examine the possibility that a prolonged immune response to beta(2)GPI could also spread to the human protein, antibodies against human beta(2)GPI (anti-beta(2)GPI) were determined in 93 randomly selected children with different allergic diseases. A high frequency (42%) of IgG anti-beta(2)GPI was found in children with atopic dermatitis (AD), but not in those with other allergic diseases. Anti-beta(2)GPI in children with AD were exclusively of the IgG1 subclass and bound to bovine beta(2)GPI as well, but not to either beta(2)GPI combined with the phospholipid cardiolipin. The epitopes were identified in domain V of beta(2)GPI and the antibody binding was abolished upon the specific proteolytic cleavage of the phospholipid-binding C-terminal loop in domain V of beta(2)GPI. These results indicated that the epitopes for anti-beta(2)GPI in children with AD most likely resided in close vicinity of the phospholipid-binding site of beta(2)GPI. The epitopic difference from anti-beta(2)GPI in APS may explain presumed non-thrombogenicity of anti-beta(2)GPI in children with AD. 相似文献
2.
A new method for evaluating hand preshaping during reaching-to-grasp movement is proposed. The method makes use of all five fingers in estimation of prehension. The investigation was performed on six healthy subjects grasping three different objects at various positions and orientations. The objects were presented to the subjects by means of a robot, which also induced perturbations in both object position and orientation. Positions of markers attached to the finger-tips and dorsum of the hand were recorded by means of a 3D optical tracking system. In the data analysis, the adjacent fingertips were interconnected, thus obtaining a planar pentagon whose various characteristics were investigated and discussed. New parameters for the evaluation of finger preshaping, such as pentagon surface area, angle between the pentagon and hand normal vectors, and the angle between the pentagon and object normal vectors were introduced. The proposed pentagon approach is expected to be useful in future work when examining grasping abilities of subjects with neuromuscular disorders. 相似文献
3.
In this paper a gait efficiency assessment method, Gait Energy Efficiency Index (GEEI), which can be used in evaluation of the progress of the rehabilitation process in disabled persons, is proposed and described. The method is based on calculation of cross correlation between normalized time courses of kinetic and potential energy of the body's centre of mass (COM). We hypothesized that GEEI in energetically optimal normal walking should be high and invariable of gait speed. The method was tested on twelve healthy subjects walking at three different speeds and contrasted to five established gait energy consumption assessment methods. The results showed that GEEI in normal walking is close to 1 regardless of walking speed. 相似文献
4.
This study examines the postural activity of partially constrained subjects for three different initial standing postures in response to disturbances in the sagittal plane. When the ankle strategy suffices for disturbance rejection in response to anterior disturbances, a mostly linear relationship between the ankle torque and ankle angle was observed, resulting in a constant stiffness at the ankles. However, when the ankle torque saturation was reached, a combined ankle-trunk postural strategy was utilized mainly in response to posterior perturbations due to the properties of the base-of-support. This caused a nonlinear scaling of ankle responses, thereby increasing variability of ankle stiffness. Distinctions in the ankle responses were also observed for different initial standing postures. The anterior initial stance generally increases the overall postural stability and renders the utilization of ankle strategy feasible, even for the rejection of posterior disturbances. Therefore, a linear torque-angle relationship at the ankles was observed for the anterior initial stance, regardless of the perturbation parameters. 相似文献
5.
Estimation of the false-negative rate in newborn screening for congenital adrenal hyperplasia 总被引:2,自引:0,他引:2
Votava F Török D Kovács J Möslinger D Baumgartner-Parzer SM Sólyom J Pribilincová Z Battelino T Lebl J Frisch H Waldhauser F;Middle European Society for Paediatric Endocrinology -- Congenital Adrenal Hyperplasia 《European journal of endocrinology / European Federation of Endocrine Societies》2005,152(6):869-874
OBJECTIVE: Newborn screening based on measurement of 17alpha-hydroxyprogesterone (17-OHP) in a dried blood spot on filter paper is an effective tool for early diagnosis of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Its most important rationale is prevention of a life-threatening salt-wasting (SW) crisis; in moderate forms of CAH, early diagnosis and treatment may prevent permanent negative effects of androgen overproduction. Our target was to analyse if all CAH patients who had been identified clinically before puberty would have been detected by the newborn screening. METHODS: Newborn screening cards of 110 CAH patients born between 1988 and 2000 in five Middle-European countries and diagnosed prior to puberty (77 SW and 33 moderate) and cards from 920 random, healthy newborn controls were analysed. CAH screening had not yet been introduced during this time. The diagnosis was based on clinical and laboratory signs and, in most cases, on CYP21 gene mutation analysis. All 17-OHP measurements in dried blood spots were carried out using a time-resolved fluoroimmunoassay kit. RESULTS: In the newborn screening blood spots, the median of 17-OHP levels was 561 nmol/l (range 91-1404 nmol/l) in subjects with the SW form and 40 nmol/l (4-247 nmol/l) in the moderate form. All 77 SW patients would have been detected by newborn screening using the recommended cut-off limits (30 nmol/l). However, 10 of 33 patients with moderate CAH would have been missed. 17-OHP levels of all controls were below the cut-off. CONCLUSION: Newborn screening is efficient for diagnosing the SW form of CAH, but is inappropriate for identifying all patients with a moderate form of CAH. It appears that the false-negative rate is at least one-third in children with the moderate form of CAH. 相似文献
6.
American College of Rheumatology Provisional Criteria for Global Flares in Childhood‐Onset Systemic Lupus Erythematosus
下载免费PDF全文
![点击此处可从《Arthritis care & research》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Hermine I. Brunner Michael Holland Michael W. Beresford Stacy P. Ardoin Simone Appenzeller Clovis A. Silva Francisco Flores Beatrice Goilav Scott E. Wenderfer Deborah M. Levy Angelo Ravelli Raju Khunchandani Tadej Avcin Marisa S. Klein‐Gitelman Brian M. Feldman Nicolino Ruperto Jun Ying the PRCSG PRINTO Investigators 《Arthritis care & research》2018,70(6):813-822
7.
Tine TESOVNIK Jernej KOVAC Tinka HOVNIK Primoz KOTNIK Tadej BATTELINO Katarina TREBUSAK PODKRAJSEK 《Slovenian Journal of Public Health》2015,54(2):74-78
Background
Type 1 diabetes (T1D) is an autoimmune chronic disease where hyperglycemia, increased risk of oxidative stress, advanced glycation end-products and other genetic and environmental factors lead to T1D complications. Shorter telomeres are associated with hyperglycemic levels and lower serum vitamin D levels.Methods
Average telomere length (ATL) in whole blood DNA samples was assessed with qPCR method in 53 Slovenian T1D children/adolescents (median age 8.7 years, 1:1.3 male/female ratio). Body mass index standard deviation score (BMI-SDS), glycated haemoglobin and serum level of vitamin D metabolite (25-(OH)-D3) and the age at the onset of T1D were collected from the available medical documentation.Results
Results indicate shorter ATL in subjects with higher BMI-SDS when compared to those with longer ATL (0.455 ± 0.438, −0.63 ± 0.295; p=0.049). Subjects with higher BMI-SDS had lower serum vitamin D levels when compared to those with lower BMI-SDS (40.66 ± 3.07 vs. 52.86 ± 4.85 nmol/L; p=0.045). Vitamin D serum levels did not significantly differ between subjects with longer/shorter ATL.Conclusion
T1D children/adolescents with shorter ATL tend to have higher BMI-SDS. Lower serum vitamin D levels were associated with higher BMI-SDS, while associations between vitamin D serum levels, age at the onset of T1D, glycated haemoglobin and ATL were not observed. Additional studies with more participants are required to clarify the role of the telomere dynamics in T1D aetiology and development of complications. 相似文献8.
Matteo Brucoli Paolo Boffano Irene Romeo Chiara Corio Arnaldo Benech Muhammad Ruslin Tymour Forouzanfar Thomas Starch‐Jensen Tanía Rodríguez‐Santamarta Juan Carlos de Vicente Johanna Snll Hanna Thorn Marko Tarle Emil Dediol Petia Pechalova Nikolai Pavlov Hristo Daskalov Iva Doykova Kadri Kelemith Tiia Tamme Andrey Kopchak Ievgen Shumynskyi Pierre Corre Helios Bertin Quentin Goguet Marine Anquetil Aurlien Louvrier Christophe Meyer Tadej Dovak David Vozli
Ane Birk Boban Ani
i Vitomir S. Konstantinovic 《Dental traumatology》2020,36(3):241-246
9.
Ludvigsson J Krisky D Casas R Battelino T Castaño L Greening J Kordonouri O Otonkoski T Pozzilli P Robert JJ Veeze HJ Palmer J Samuelsson U Elding Larsson H Åman J Kärdell G Neiderud Helsingborg J Lundström G Albinsson E Carlsson A Nordvall M Fors H Arvidsson CG Edvardson S Hanås R Larsson K Rathsman B Forsgren H Desaix H Forsander G Nilsson NÖ Åkesson CG Keskinen P Veijola R Talvitie T Raile K Kapellen T Burger W Neu A Engelsberger I Heidtmann B Bechtold S Leslie D Chiarelli F Cicognani A 《The New England journal of medicine》2012,366(5):433-442
10.
Analysing diffuse reflectance spectra to extract properties of biological tissue requires modelling of light transport within the tissue, considering its absorption, scattering, and geometrical properties. Due to the layered skin structure, skin tissue models are often divided into multiple layers with their associated optical properties. Typically, in the analysis, some model parameters defining these properties are fixed to values reported in the literature to speed up the fitting process and improve its performance. In the absence of consensus, various studies use different approaches in fixing the model parameters. This study aims to assess the effect of fixing various model parameters in the skin spectra fitting process on the accuracy and robustness of a GPU-accelerated two-layer inverse adding-doubling (IAD) algorithm. Specifically, the performance of the IAD method is determined for noiseless simulated skin spectra, simulated spectra with different levels of noise applied, and in-vivo measured reflectance spectra from hyperspectral images of human hands recorded before, during, and after the arterial occlusion. Our results suggest that fixing multiple parameters to a priori known values generally improves the robustness and accuracy of the IAD algorithm for simulated spectra. However, for in-vivo measured spectra, these values are unknown in advance and fixing optical parameters to incorrect values significantly deteriorates the overall performance. Therefore, we propose a method to improve the fitting performance by pre-estimating model parameters. Our findings could be considered in all future research involving the analysis of diffuse reflectance spectra to extract optical properties of skin tissue. 相似文献