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Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies 下载免费PDF全文
Matteo Grammatico MD Luisa Vuolo MD PhD Giacomo Emmi MD PhD Giovanna Carlucci MD PhD Gregorio Spagni MD Alessandro Barilaro MD PhD Anna Maria Repice MD Lorenzo Emmi MD Domenico Prisco MD Vittorio Martinelli MD Roberta Scotti MD Niloufar Sadeghi MD PhD Gaetano Perrotta MD Pascal Sati PhD Bernard Dachy MD Daniel S. Reich MD PhD Massimo Filippi MD Luca Massacesi MD 《Annals of neurology》2018,83(2):283-294
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M. Gastaldi S. Mariotto M. P. Giannoccaro R. Iorio M. Zoccarato M. Nosadini L. Benedetti S. Casagrande M. Di Filippo M. Valeriani S. Ricci S. Bova C. Arbasino M. Mauri M. Versino F. Vigevano L. Papetti M. Romoli C. Lapucci F. Massa S. Sartori L. Zuliani A. Barilaro P. De Gaspari G. Spagni A. Evoli R. Liguori S. Ferrari E. Marchioni B. Giometto L. Massacesi D. Franciotta 《European journal of neurology》2020,27(4):633-643
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Monte Gabriele Spagni Gregorio Damato Valentina Iorio Raffaele Marino Mariapaola Evoli Amelia 《Journal of neurology》2021,268(5):1803-1807
Journal of Neurology - Anti-acetylcholine receptor antibodies (AChR Abs) are detected in 85% of myasthenia gravis (MG) patients, at higher rates in patients with late-onset disease. AChR Ab... 相似文献
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Lucia Campetella Claudia Papi Gregorio Spagni Eleonora Sabatelli Sara Mariotto Matteo Gastaldi Gianvito Masi Sara Carta Lara Ahmad Francesca Rossi Giorgia Teresa Maniscalco Giovanna De Luca Raffaele Iorio 《European journal of neurology》2023,30(8):2534-2538
Background and purpose
Longitudinally extensive transverse myelitis (LETM) associated with aquaporin-4 autoantibodies (AQP4-IgG) can cause severe disability. Early diagnosis and prompt treatment are critical to prevent relapses. A novel score is described based on clinical and neuroimaging characteristics that predicts AQP4-IgG positivity in patients with LETM.Methods
Patients were enrolled both retrospectively and prospectively from multiple Italian centers. Clinical and neuroimaging characteristics of AQP4-IgG positive and negative patients were compared through univariate and multivariate analysis.Results
Sixty-six patients were included. Twenty-seven (41%) were AQP4-IgG positive and median age at onset was 45.5 years (range 19–81, interquartile range 24). Female sex (odds ratio [OR] 17.9, 95% confidence interval [CI] 2.6–381.9; p = 0.014), tonic spasms (OR 45.6, 95% CI 3.1–2197; p = 0.017) and lesion hypointensity on T1-weighted images (OR 52.9, 95% CI 6.8–1375; p = 0.002) were independently associated with AQP4-IgG positivity. The AQP4-IgG positivity in myelitis (AIM) score predicted AQP4-IgG positivity with 85% sensitivity and 95% specificity. Positive and negative likelihood ratios were 16.6 and 0.2 respectively. The inter-rater and intra-rater agreement in the score application were both excellent.Conclusions
The AIM score predicts AQP4-IgG positivity with good sensitivity and specificity in patients with a first episode of LETM. The score may assist clinicians in early diagnosis and treatment of AQP4-IgG positive LETM. 相似文献
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