全文获取类型
收费全文 | 1164篇 |
免费 | 77篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 64篇 |
妇产科学 | 9篇 |
基础医学 | 138篇 |
口腔科学 | 37篇 |
临床医学 | 111篇 |
内科学 | 178篇 |
皮肤病学 | 8篇 |
神经病学 | 99篇 |
特种医学 | 183篇 |
外科学 | 78篇 |
综合类 | 13篇 |
预防医学 | 126篇 |
眼科学 | 67篇 |
药学 | 71篇 |
肿瘤学 | 56篇 |
出版年
2021年 | 7篇 |
2020年 | 6篇 |
2018年 | 10篇 |
2017年 | 7篇 |
2016年 | 6篇 |
2015年 | 11篇 |
2014年 | 22篇 |
2013年 | 38篇 |
2012年 | 32篇 |
2011年 | 32篇 |
2010年 | 35篇 |
2009年 | 29篇 |
2008年 | 42篇 |
2007年 | 28篇 |
2006年 | 28篇 |
2005年 | 34篇 |
2004年 | 27篇 |
2003年 | 31篇 |
2002年 | 27篇 |
2001年 | 26篇 |
2000年 | 29篇 |
1999年 | 24篇 |
1998年 | 37篇 |
1997年 | 32篇 |
1996年 | 38篇 |
1995年 | 39篇 |
1994年 | 38篇 |
1993年 | 27篇 |
1992年 | 19篇 |
1991年 | 32篇 |
1990年 | 29篇 |
1989年 | 34篇 |
1988年 | 39篇 |
1987年 | 43篇 |
1986年 | 25篇 |
1985年 | 32篇 |
1984年 | 24篇 |
1983年 | 24篇 |
1982年 | 23篇 |
1981年 | 21篇 |
1980年 | 15篇 |
1979年 | 10篇 |
1978年 | 16篇 |
1977年 | 17篇 |
1976年 | 24篇 |
1975年 | 14篇 |
1974年 | 6篇 |
1973年 | 6篇 |
1972年 | 11篇 |
1970年 | 6篇 |
排序方式: 共有1242条查询结果,搜索用时 15 毫秒
1.
M K Sorenson 《Physical therapy》1989,69(12):1059-1064
The purpose of this article is to increase the therapist's awareness of the effects of edema on the hand and the need for early treatment. The physiology of tissue fluid production and the two basic types of edema are discussed. The use of elevation, compression, and active exercise are the primary methods of controlling edema in the hand. Various modalities and commercial compression dressings are helpful for intractable edema; however, early intervention and treatment of the edematous hand can prevent subsequent hand dysfunction and sequelae. 相似文献
2.
Jennifer M Griffith James R Sorenson J Michael Bowling Tracey Jennings-Grant 《Health education & behavior》2005,32(5):613-626
The Enhancing Patient Prenatal Education study tested the feasibility and educational impact of an interactive program for patient prenatal genetic screening and testing education. Patients at two private practices and one public health clinic participated (N = 207). The program collected knowledge and measures of anxiety before and after use of the tool. Time in various prenatal visit activities was collected prior to and after the introduction of the education tool. Providers completed an assessment of their experiences with patients who had used the program. Results indicate that patient knowledge significantly increased from pre to post (p = .0001) with no increase in anxiety (p = .31). Time in clinic activities, including overall visit time, increased. A majority of providers indicated that the program disrupted clinic flow. This assessment suggests that the program increases patient knowledge and does not increase patient anxiety. However, challenges remain to using this program in a clinic setting. 相似文献
3.
M Roch-Arveiller V Revelant D Pham Huy L Maman J Fontagne J R Sorenson J P Giroud 《Agents and actions》1990,31(1-2):65-71
Interaction between anti-inflammatory drugs and reactive oxygen metabolites must be considered in the course of pharmacological studies intended to develop new compounds. Effects of indomethacin, aspirin, and 3,5-diisopropylsalicylic acid (3,5-DIPS) and their copper complexes on PMNL oxidative metabolism and the evolution of an acute inflammatory reaction were studied in the rat. Experiments were performed in vitro by assessment of superoxide generation and reduction of chemiluminescence by PMNLs incubated or not (control) in medium containing various concentrations of these compounds. A dose-related decrease of these parameters was observed, however, copper complexes were found to be more effective than their parent drugs or Cu gluconate. Copper complexes were also more effective anti-inflammatory agents than their parent ligands or Cu gluconate when the volume of exudate and number of exudate PMNLs were assessed after induction of pleurisy in rats by injection of isologous serum. It is concluded that modulation of the PMNL oxidative burst by copper complexes offers an accounting for the anti-inflammatory activity of these compounds. 相似文献
4.
A general model is developed for segmenting magnetic resonance images using vector decomposition and probabilfty techniques. Each voxel is assigned fractional volumes of q tissues from p differently weighted images (q ≤ p + 1) in the presence of partial-volume mixing, random noise, and other tissues. Compared wtth the eigenimage method, fewer differently weighted images are needed for segmenting the q tissues, and the contrast-to-noise ratio in the calculated fractional volumes is improved. The model can produce com-posrte tissue-type images similar to that of the probability methods, by comparing the fractional volumes assigned to different tissues on each voxel. A three-tissue (p = 2, q = 3) model is illustrated for segmenting three tissues from dual-echo images. M provides statistical analysis to the algebraic method. A three-compartment phantom is segmented for validation. Two clinical examples are presented. 相似文献
5.
Acute appendicitis: CT and US correlation in 100 patients 总被引:19,自引:1,他引:18
6.
Perforated colorectal neoplasms: correlation of clinical, contrast enema, and CT examinations 总被引:2,自引:0,他引:2
Hulnick DH; Megibow AJ; Balthazar EJ; Gordon RB; Surapenini R; Bosniak MA 《Radiology》1987,164(3):611-615
Results of clinical, contrast enema (CE), and computed tomographic (CT) examinations in 39 patients with perforated colorectal neoplasms were retrospectively reviewed. Twenty patients were toxemic at initial presentation, but in only four patients was the diagnosis of perforated colorectal neoplasm initially suspected clinically. CE study was performed in 22 patients and enabled the diagnosis of perforated neoplasm in 11 cases, neoplasm alone in eight, and neither neoplasm nor perforation in three. CT was performed in 38 patients and enabled the diagnosis of perforated neoplasm in 36; pericolic phlegmon but no mass lesion was evident in two. In 16 patients, CT also demonstrated metastatic disease. Because of its reliability in establishing the diagnosis and staging the extent of the inflammatory and neoplastic disease, CT is indicated in cases of suspected or proved perforated colorectal neoplasm and in cases in which CE study findings are indeterminate or suggestive of perforated neoplasm. 相似文献
7.
J A Sorenson C R Mitchell J D Armstrong H Mann D G Bragg F A Mann I B Tocino M M Wojtowycz 《Investigative radiology》1987,22(10):772-780
We evaluated the effects of unsharp masking and highly efficient scatter rejection on film-screen chest radiographs of cancer patients. Unsharp masking significantly improved the detectability of lung nodules and visibility of anatomic structures in poorly penetrated areas of the chest. Highly efficient scatter rejection by an improved antiscatter grid provided only modest additional benefits. The study supports the conclusion that nodule detection in poorly penetrated areas on conventional chest radiographs is limited primarily by display contrast, whereas in the well-penetrated lung fields it is limited primarily by confusing background structures, rather than inadequate contrast. A method for analyzing clinical nodule detection data by transforming the FROC data to ROC coordinates also is demonstrated. 相似文献
8.
9.
Steenbergen EJ; Verhagen OJ; van Leeuwen EF; van den Berg H; von dem Borne AE; van der Schoot CE 《Blood》1995,86(2):692-702
Crosslineage T-cell receptor delta (TCR delta) rearrangements are widely used as tumor markers for the follow up of minimal residual disease in childhood B-precursor acute lymphoblastic leukemia (ALL) by polymerase chain reaction (PCR). The major drawback of this approach is the risk of false-negative results due to clonal evolution. We investigated the stability of V delta 2D delta 3 rearrangements in a group of 56 childhood B-precursor ALL patients by PCR and Southern blot analysis. At the PCR level, V delta 2D delta 3-to-J alpha rearranged subclones (one pathway for secondary TCR delta recombination) were demonstrated in 85.2% of V delta 2D delta 3-positive patients tested, which showed that small subclones are present in the large majority of patients despite apparently monoclonal TCR delta Southern blot patterns. Sequence analysis of V delta 2D delta 3J alpha rearrangements showed a biased J alpha gene usage, with HAPO5 and J alpha F in 26 of 32 and 6 of 32 clones, respectively. Comparison of V delta 2D delta 3 rearrangement status between diagnosis and first relapse showed differences in seven of eight patients studied. In contrast, from first relapse onward, no clonal changes were observed in six patients studied. To investigate the occurrence of crosslineage TCR delta rearrangements in normal B and T cells, fluorescence-activated cell sorter-sorted peripheral blood CD19+/CD3- and CD19-/CD3+ cell populations from three healthy donors were analyzed. V delta 2D delta 3 rearrangements were detected at low frequencies in both B and T cells, which suggests that V delta 2-to-D delta 3 joining also occurs during normal B-cell differentiation. A model for crosslineage TCR delta rearrangements in B-precursor ALL is deduced that explains the observed clonal changes between diagnosis and relapse and is compatible with multistep leukemogenesis of B-precursor ALL. 相似文献
10.
Y E Shen W G Sorenson D M Lewis S A Olenchock 《Biomedical and environmental sciences : BES》1990,3(3):353-363
Fourteen samples of settled dust from two factories processing rice and wheat straw near Shanghai, China, were examined by dilution plating for total bacteria, gram-negative bacteria, thermophilic actinomycetes, and fungi. They were also examined for aflatoxin, endotoxin, and potential to stimulate production of human interleukin 1 beta (IL-1 beta) and to consume complement. The concentrations of total microorganisms were consistently greater than 10(7) CFU/g and ranged from 10(7) to 10(9) CFU/g. In general, the level of microbial contamination was greater in the hay dust samples than in the rice dust samples, with bacteria being the most numerous microorganisms observed followed by molds, thermophilic actinomycetes, and yeasts. The predominant fungi were species of Aspergillus, Cladosporium, Penicillium, Trichosporon, and Cryptococcus. No significant levels of aflatoxin were observed and the isolates of A. flavus examined lack significant aflatoxigenic potential. The levels of microorganisms in these samples, the types of organisms found, and the inflammatory mediators such as endotoxin suggest that workers exposed to these dusts may be at risk for respiratory illness. 相似文献