全文获取类型
收费全文 | 3476篇 |
免费 | 229篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 71篇 |
儿科学 | 88篇 |
妇产科学 | 77篇 |
基础医学 | 502篇 |
口腔科学 | 29篇 |
临床医学 | 324篇 |
内科学 | 514篇 |
皮肤病学 | 114篇 |
神经病学 | 570篇 |
特种医学 | 323篇 |
外科学 | 500篇 |
综合类 | 23篇 |
预防医学 | 140篇 |
眼科学 | 133篇 |
药学 | 152篇 |
中国医学 | 3篇 |
肿瘤学 | 148篇 |
出版年
2023年 | 21篇 |
2022年 | 28篇 |
2021年 | 50篇 |
2020年 | 38篇 |
2019年 | 58篇 |
2018年 | 72篇 |
2017年 | 63篇 |
2016年 | 56篇 |
2015年 | 102篇 |
2014年 | 85篇 |
2013年 | 125篇 |
2012年 | 176篇 |
2011年 | 184篇 |
2010年 | 113篇 |
2009年 | 92篇 |
2008年 | 156篇 |
2007年 | 155篇 |
2006年 | 144篇 |
2005年 | 133篇 |
2004年 | 142篇 |
2003年 | 126篇 |
2002年 | 116篇 |
2001年 | 130篇 |
2000年 | 113篇 |
1999年 | 93篇 |
1998年 | 46篇 |
1997年 | 45篇 |
1996年 | 31篇 |
1995年 | 33篇 |
1994年 | 27篇 |
1993年 | 28篇 |
1992年 | 76篇 |
1991年 | 57篇 |
1990年 | 55篇 |
1989年 | 52篇 |
1988年 | 63篇 |
1987年 | 48篇 |
1986年 | 51篇 |
1985年 | 61篇 |
1984年 | 34篇 |
1983年 | 34篇 |
1982年 | 25篇 |
1981年 | 22篇 |
1980年 | 20篇 |
1979年 | 35篇 |
1977年 | 19篇 |
1976年 | 18篇 |
1975年 | 23篇 |
1974年 | 22篇 |
1972年 | 18篇 |
排序方式: 共有3711条查询结果,搜索用时 15 毫秒
1.
Rene S. Hendriksen Pimlapas Leekitcharoenphon Matthew Mikoleit Jacob Dyring Jensen Rolf Sommer Kaas Louise Roer Heena B. Joshi Srirat Pornruangmong Chaiwat Pulsrikarn Gladys D. Gonzalez-Aviles E. Ascelijn Reuland Nashwan Al Naiemi Astrid Louise Wester Frank M. Aarestrup Henrik Hasman 《Journal of clinical microbiology》2015,53(2):677-680
One unreported case of extended-spectrum-beta-lactamase (ESBL)-producing Salmonella enterica serovar Typhi was identified, whole-genome sequence typed, among other analyses, and compared to other available genomes of S. Typhi. The reported strain was similar to a previously published strain harboring blaSHV-12 from the Philippines and likely part of an undetected outbreak, the first of ESBL-producing S. Typhi. 相似文献
2.
We report a case of dichorionic, diamniotic twins who developed similar erythematous, annular, erosive plaques in the inguinal folds in the first few weeks of life that were refractory to topical antifungals and oral antibiotics. The twins were found to have high transaminase levels, antinuclear antibody positivity, and anti‐SSS/Ro) and anti‐SSB/La autoantibodies. The rash resolved without scarring by 7 months of age with the use of low‐potency topical corticosteroids. We suggest that physicians consider neonatal lupus erythematosus in neonates with atypical eruptions occurring in sun‐protected skin. 相似文献
3.
4.
A brief review of the developmental background of the lateral cervical sinuses, fistulas, cysts and auricles has been presented. In all likelihood they are of branchial cleft origin. Surgical excision is the recommended treatment as shown in the cases described. 相似文献
5.
6.
JA HYEON KU CHEOL KWAK SEUNG-JUNE OH EUNSIK LEE SANG EUN LEE JAE-SEUNG PAICK 《International journal of urology》2004,11(7):489-493
BACKGROUND: Our aims in the present study were to estimate the influences of pain and urinary symptoms on quality of life, and to determine which of these two variables has the most predictive power with respect to quality of life in young men with chronic prostatitis-like symptoms. METHODS: Chronic prostatitis-like symptoms were measured by the National Institutes of Health-Chronic Prostatitis Symptom Index. Of the 28,841 men aged 20 years who lived in the study community, 18,495 men (a response rate 64.1%) agreed to participate in the study. A total of 1057 men who complained of symptoms indicative of chronic prostatitis were included in the study. The influences of pain and urinary symptoms on quality of life were determined using logistic regression analysis. The receiver operating characteristic (ROC) curve was used to estimate the predictive ability of each of these variables with respect to quality of life. RESULTS: Results from multivariate analysis showed that both pain and urinary symptoms were associated with an increased likelihood of impaired quality of life, although pain contributed more to a reduced quality of life than urinary symptoms. Relative to men who experienced mild pain, men who experienced moderate pain had a 3.9-fold risk of poor quality of life (odds ratio [OR], 3.87; 95% confidence interval [CI], 2.86-5.23; P < 0.001) and those who experienced severe pain had a 15.7-fold risk of reduced quality of life (OR, 15.68; 95% CI, 6.59-37.35; P < 0.001). Moderate urinary symptoms were associated with a 1.4-fold risk of bother (OR, 1.41; 95% CI, 1.01-1.99; P < 0.001) and severe urinary symptoms were associated with 2.4-fold risk (OR, 2.39; 95% CI, 1.37-4.12; P < 0.001), relative to mild urinary symptoms. Comparison of the effects of pain and urinary symptoms showed that pain severity had the most predictive power for bother, quality of life, and quality-of-life impact. The areas under the ROC curves for bother, quality of life, and quality-of-life impact were 71.3%, 69.3% and 72.5%, respectively. CONCLUSION: Urinary symptoms and pain might be associated with an increased likelihood of impaired quality of life in young men with chronic prostatitis-like symptoms. In addition, our findings suggest that pain severity is the most influential variable for determining quality of life in this population. 相似文献
7.
Two-tiered DNA-based diagnosis of transthyretin amyloidosis reveals two novel point mutations 总被引:4,自引:0,他引:4
We analyzed 11 consecutive unrelated cases of polyneuropathy due to transthyretin amyloidosis. Direct sequencing of the promoter region, exons, and splice junctions revealed that each patient was heterozygous for a mutation: six patients had valine 30 substituted by methionine (V30----M; Portuguese-Japanese type), one had threonine 60 substituted by alanine (T60----A; Appalachian type), and two had serine 77 substituted by tyrosine (S77----Y; Illinois type). In addition, two patients had previously undescribed mutation: phenylalanine 33 substituted by leucine (F33----L) and phenylalanine 64 substituted by leucine (F64----L). From present information, the probands of these novel mutations do not exhibit any pathology that clearly distinguishes them from individuals with the other mutations. The mutations extend the range of mutations associated with amyloidotic polyneuropathy. In our 11 patients, the different mutations did not seem to correlate with distinct clinical phenotypes. We developed PASA assays (PCR amplification of specific alleles) for each of the five mutations. PASA can be used by any diagnostic laboratory that can perform PCR to rapidly detect any of the known mutations. The minority of samples with an undescribed mutation can be sent to a specialty laboratory for delineation of the mutation by direct genomic sequencing. The presently described combination of methods may have widespread utility in the diagnosis of genetic disease. 相似文献
8.
U. Meyding-Lamadé K. Rieke D. Krieger W. Hacke Michael Forsting Klaus Sartor Christian Sommer 《Journal of neurology》1995,242(5):335-343
Acute ischaemia of the vertebrobasilar circulation leads to a variety of clinical manifestation and is mostly due to cardiogenic or artery-to-artery embolism. We describe four neurological emergency situations involving vertebrobasilar artery aclusion of other origins: basilar migraine, extrinsic compression by rheumatoid inflammatory tissue, generalized vasculitis in subacute rheumatic fever and basilar artery dissection. The differential diagnosis of acute vertebrobasilar artery occlusion may have an important impact on patient management. 相似文献
9.
Lyme disease is a cause of illness involving multiple organ systems, including, in 10–15 % of cases, the nervous system.
Peripheral radiculoneuritis, cranial neuritis, encephalitis and myelitis are among the neurological manifestations found in
the second and third stages. We present the MRI findings in isolated oculomotor nerve involvement by Lyme disease and discuss
the differential diagnosis.
Received: 14 June 1995 Accepted: 16 January 1996 相似文献
10.
Persistent developmental stuttering (PDS) shares clinical features with task-specific dystonias. In these dystonias, intracortical inhibition is abnormally weak. We therefore sought to determine intracortical inhibition and intracortical facilitation in PDS. In 18 subjects with PDS since childhood (mean age, 39.4 [SD 13.0] years) and 18 speech-fluent controls (43.6 [14.3] years), we investigated resting and active motor thresholds as well as intracortical inhibition and facilitation of the optimal representation of the abductor digiti minimi of the dominant hand using transcranial magnetic stimulation. In PDS, the resting and active motor thresholds were increased, whereas intracortical inhibition and facilitation were normal. Normal intracortical excitability makes a pathophysiological analogy between focal dystonia and PDS less likely. The enhanced motor threshold suggests reduced motor cortical neuronal membrane excitability in PDS. 相似文献